Method for biological functionalization of silicon-based material surface

A biofunctionalized, silicon-based material technology, applied in the treatment of dyed organosilicon compounds, fibrous fillers, etc., can solve the problems of inactivation of biomolecules, high reaction specificity, and low coupling rate of biomolecules. Strong operability, wide applicability and high reproducibility
CN105295447AInactive Publication Date: 2016-02-03DALIAN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
DALIAN UNIV OF TECH
Publication Date
2016-02-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for biological functionalization of a silicon-based material surface and a functionalized silicon-based material prepared by the method. The method is a method for connecting a hydroxylated silicon-based material subjected to surface modification through a sulfydryl / aminosilane coupling agent and biomolecules by divinyl sulphone. The method takes the commercialized sulfydryl / aminosilane coupling agent and the divinyl sulphone as coupling reagents, and is free from pretreatment, high in operability, high in reproducibility and wide in applicability; the divinyl sulphone can react with sulfydryl, azyl and hydroxyl, is suitable for the biomolecules and has broad spectrum property; related reactions are performed in an aqueous solution; the method is mild in condition and environment-friendly, and is a broad-spectrum method with large potential for biological functionalization of the silicon-based material surface.
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Description

technical field

[0001] The invention relates to a method and application of biological functionalization of the surface of silicon-based materials, in particular to a method and application of biologically active and inert functionalization of the surface of inorganic silicon materials based on natural biomolecules. technical background

[0002] As a material with low price, many types, wide application, high stability and strong processability, silicon-based materials can be seen everywhere in our daily life and scientific research, such as single crystal silicon, glass, optical fiber, etc., are widely used in Aerospace, electrical and electronic, construction, transportation, energy, chemical, textile, food, light industry, medical, agricultural and other industries. On the other hand, silicon-based materials have good stability and biocompatibility under physiological conditions, making them widely used in biomedical fields such as cell culture, biochips, drug delivery, a...

Claims

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