A tophi dispersant and preparation method thereof

Abstract

The invention discloses uratoma resolvent. The uratoma resolvent is prepared from 0.1-0.2 g of sodium dihydrogen phosphate dihydrate, 6-7 g of disodium hydrogen phosphate dodecahydrate and 100 ml of ultra-pure water; a preparation method comprises the steps of separately preparing 1000 ml of a sodium dihydrogen phosphate solution with the concentration being 0.2 mol / L and 1000 ml of a disodium hydrogen phosphate solution with the concentration being 0.2 mol / L, selecting 5.3 ml of the sodium dihydrogen phosphate solution and 94.7 ml of the disodium hydrogen phosphate solution with the concentration being 0.2 mol / L through an automatic potentiometric titrator, mixing and sufficiently stirring the selected solutions, adding alkalizer to the mixture, and adjusting and controlling the PH value to be 8 through PH test paper. The uratoma resolvent is convenient to use, safe and reliable and has no influence on cell viability, and no soft tissue damage is caused; uratoma can be dissolved rapidly and effectively, operation time can be shortened, the operation curative effect can be improved, and an operation can even be avoided through local injection treatment.

Description

technical field [0001] The invention relates to a flushing agent, in particular to a tophus dissipating agent and a preparation method thereof. Background technique [0002] In the course of the onset of gout patients, there will be a hard nodule like a stone, called "tophi", also known as gout nodules. This is a nodular swelling formed by the deposition of sodium urate crystals in soft tissues, causing chronic inflammation and fibrous tissue proliferation. Regarding the pathogenesis of gouty arthritis, many scholars generally believe that it is related to polymorphonuclear leukocytes. In gout, the sodium urate crystals released by the synovial tissue and articular cartilage are swallowed by the white blood cells in the joint fluid, and the white blood cells rupture to release proteases and inflammatory factors into the synovial fluid. Enzyme inflammatory factors increase the number of white blood cells in the joints, so more white blood cells that have swallowed urate cry...

AI Technical Summary

Problems solved by technology

However, tophi often grows in large numbers and infiltrates, and is seriously adhered to the mucous membrane and attached to the bone surface. If the tophi is sought to be completely removed, surgical treatment is likely to cause damage to soft tissues and nerves, and more likely to cause bone destruction. new fractures

Therefore, surgical treatment at this stage is difficult to completely remove tophi, and the effect is not good.

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