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Dihydroartemisinin piperaquine dry suspension agent and preparation process thereof

A technology of dihydroartemisinin and dry suspension is applied in the directions of non-active ingredients medical preparations, active ingredients containing medical preparations, organic active ingredients, etc. Dissolution and other problems, to achieve the effect of good taste, stable quality and simple preparation method

Inactive Publication Date: 2016-03-09
贝克诺顿(浙江)制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dihydroartemisinin-piperaquine dry suspension is a compound preparation composed of dihydroartemisinin and piperaquine phosphate. Since piperaquine phosphate is a drug with a significant bitter taste, adding flavors, sweeteners, etc. will not be effective. To cover up its bitterness, it can effectively cover up its bitterness by using glyceric acid behenate to encapsulate piperaquine phosphate, but glyceric acid behenate will degrade dihydroartemisinin. If it is made into a coated tablet, it will It will affect the dissolution of the main ingredients. Therefore, there is an urgent need for a technology that can significantly improve the bitterness of piperaquine phosphate, improve the patient's clinical medication compliance, and is more suitable for children.

Method used

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  • Dihydroartemisinin piperaquine dry suspension agent and preparation process thereof
  • Dihydroartemisinin piperaquine dry suspension agent and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Prepare according to the following preparation process: under the conditions of temperature ≤ 25 ° C and relative humidity ≤ 45%, follow the steps below:

[0015] (1) Take the raw and auxiliary materials of the above prescription amount, pulverize them, sieve them through a 60-mesh sieve, and dry them under normal pressure at 40±5°C for 5 hours;

[0016] (2) Pour the dried raw and auxiliary materials into the mixer for initial mixing for 60 minutes;

[0017] (3) Carry out a dry granulation on the mixed material, and sieve it through a 16-mesh sieve; sieve the material obtained from the first granulation, and collect dry particles A between 16 mesh and 40 mesh.

[0018] (4) The materials above 16 mesh are pulverized and the materials below 40 mesh are subjected to secondary granulation, the obtained particles are sieved, the materials above 16 mesh are crushed and granulated, and all particles B after secondary granulation are collected.

[0019] (5) After final ...

Embodiment 2

[0021] Material name

[0022] The preparation method is the same as in Example 1.

Embodiment 3

[0024] Material name

[0025] The preparation method is the same as in Example 1.

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Abstract

The invention belongs to the field of medical preparations and in particular provides a dihydroartemisinin piperaquine dry suspension agent. The dihydroartemisinin piperaquine dry suspension agent is prepared from dihydroartemisinin, piperaquine phosphate, sodium carbonate and pharmaceutically acceptable auxiliary materials, wherein the weight ratio of the dihydroartemisinin to the piperaquine phosphate to the sodium carbonate is (10 to 30) : (140 to 180) : (10 to 46). The technology can be used for remarkably improving the bitter taste of the piperaquine phosphate and improving the compliance of clinical medication for patients, and is more suitable for medication for children patients.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a dihydroartemisinin-piperaquine dry suspension and a preparation process thereof. Background technique [0002] Malaria is a vicious disease transmitted by mosquitoes. Through nationwide prevention and control work, malaria has basically disappeared in my country, and only a few cases have occurred in individual areas in Hainan Province. But in underdeveloped tropical countries, especially in sub-Saharan Africa, malaria still seriously threatens the health and life of local people. According to the report of the World Health Organization (WHO), malaria kills a child under the age of 5 every 30 seconds on average, and about 1-2 million people die from malaria every year, and the annual number of malaria cases in the world reaches 300-500 million. [0003] Dihydroartemisinin-piperaquine dry suspension is a compound preparation composed of dihydroartemisinin and piperaquine phosphate. Dih...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K9/16A61K47/04A61P33/06A61K31/366
CPCA61K31/366A61K9/1652A61K31/496A61K47/02A61K2300/00
Inventor 吴伟薛春雅钱佳旦王小平
Owner 贝克诺顿(浙江)制药有限公司
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