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Inosine and glucose injection and preparation method thereof

A technology of glucose injection and preparation method, which is applied in the direction of medical formula, medical preparations containing active ingredients, blood diseases, etc. It can solve the problems of low product stability and adverse reactions, so as to ensure stability and reduce adverse reactions The effect of the reaction

Inactive Publication Date: 2016-03-23
JIANGSU CHENPAI PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] During the use of inosine glucose injection, the stability of the product is not very high, and at the same time, adverse reactions occur during clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] Inosine Glucose Injection, every 1000ml of Inosine Glucose Injection contains the following ingredients:

[0019] Inosine 5.8-6.2g;

[0020] Glucose 48-52g;

[0021] The balance of water for injection.

[0022] After condition screening, control inosine 5.8-6.2g; glucose 48-52g, which ensures isotonicity with plasma; intermediate pH is controlled at 5.5-6.5, which ensures the stability of the product and reduces the risk of adverse reactions in clinical use. occur.

[0023] The preparation method of inosine glucose injection comprises the following steps:

[0024] a. Add water for injection with 40% of the volume of the concentrated pot in the concentrated pot, heat to boil, put in the prescribed amount of glucose under stirring, stir to dissolve, add 0.05% activated carbon (w / v) for injection to boil, shake to cool, and use Titanium rod filter is pressurized and filtered, after 20-25 minutes of circulation, the thick dosing liquid is obtained, and then the thick do...

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PUM

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Abstract

The invention discloses an inosine and glucose injection. Each 1000 ml of the inosine and glucose injection contains 5.8-6.2 g of inosine, 48-52 g of glucose and the balance injection water. The invention further discloses a preparation method of the inosine and glucose injection. The preparation method includes the steps that injection water accounting for 40% of the volume of a concentrated solution pot is added into the concentrated solution pot and heated to boil, a formulated amount of glucose is put in with stirring, 0.05% (w / v) needle activated carbon is added for boiling, shaking stirring and cooling are performed, pressure filtration is performed, a concentrated solution is obtained, and the concentrated solution is pumped into a diluted solution pot; the concentrated solution is pumped in, 0.01% (w / v) needle activated carbon is added, then inosine is added, injection water is added to the full dose, and filling is performed after the standards that the glucose content is 97.0-102.0% the labeled amount, the inosine content is 94.0-102.0% the labeled amount and the PH is controlled to range from 5.5 to 6.5 are met. The inosine content and the glucose content are controlled through condition screening, and thus iso-osmia with plasma is guaranteed; the PH of an intermediate is controlled to range from 5.5 to 6.5, and thus the stability of the product is guaranteed; meanwhile, adverse reactions are reduced when the inosine and glucose injection is in clinical use.

Description

technical field [0001] The invention relates to an inosine glucose injection. [0002] The invention also relates to a preparation method of inosine glucose injection. Background technique [0003] Inosine Glucose Injection is indicated for coenzyme drugs, which can improve the metabolism of the body. It is used for adjuvant treatment of leukopenia and thrombocytopenia caused by various reasons, heart failure, angina pectoris, hepatitis, etc.; it can also be used for adjuvant treatment of optic atrophy and central retinitis. General specification 250ml: inosine 0.6g and glucose 12.5g. Intravenous infusion, 0.2-0.6g (calculated as inosine) each time, 1-2 times a day. [0004] During the use of inosine glucose injection, the stability of the product is not very high, and at the same time, adverse reactions may occur during clinical use. [0005] Therefore, there is an urgent need for an improved technology to solve this problem in the prior art. Contents of the invention...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61K9/08A61P7/00A61P9/04A61P9/10A61P1/16A61P25/02A61K31/7004
CPCA61K31/7076A61K9/0019A61K9/08A61K31/7004A61K2300/00
Inventor 李建新高秀兵陈泳海
Owner JIANGSU CHENPAI PHARM GRP CO LTD