3D-printed peripheral nerve conduit and preparing method thereof

Abstract

The invention relates to a 3D-printed peripheral nerve conduit which comprises a casing. One or more hexagonal prism tubes are arranged in the casing, a plurality of nerve growth factor carrier balls are arranged in the hexagonal prism tubes, and nerve growth factors are carried in the nerve growth factor carrier balls. The 3D-printed peripheral nerve conduit is more stable and integral in structure, meanwhile, nerve growth factors can be supplied in a gradient mode, and thus nerve regeneration can be better facilitated.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a 3D printed peripheral nerve catheter and a preparation method thereof. Background technique [0002] Severe peripheral nerve injury (especially the most severe Sunderland V type - nerve defect injury), common in avulsion injuries, cutting injuries, and severe stretch and crush injuries. This type of peripheral nerve injury has no possibility of self-healing because not only the nerve trunk is completely broken, but also there are gaps of varying degrees between the broken ends. Up to now, domestic and foreign medical treatment for peripheral nerve defects mainly focuses on autologous nerve transplantation and artificial nerve transplantation, but due to many shortcomings of autologous nerve transplantation, such as limited donor nerves, increased trauma, dysfunction and surgical risks Therefore, the research and development of artificial nerves has always been a research hotspot...

AI Technical Summary

Problems solved by technology

After the previous nerve conduit is implanted in the body, the nerve fiber regeneration method is still disordered and chaotic, and the proximal motor and sensory nerve fibers themselves grow in the corresponding perineurium, but the good order will be lost in the previous conduit Sexuality and directionality, showing mixed growth, which greatly reduces the efficiency of nerve regeneration, and even if the regenerated nerve fibers reach the distal stump, they cannot be correctly docked with the distal motor and sensory nerve fiber bundles, so there is a large rate of nerve fiber misconnection , seriously affected the effect of nerve regeneration

In addition, the nerve regeneration process itself is slow, so all previous nerve conduits were limited to repairing nerve defects within 3 cm, and nerve defects exceeding 3 cm, due to long-term denervation of the effector organs at the distal nerve fiber endings, the corresponding function cannot be achieved. achieve effective recovery

Therefore, several kinds of tissue-engineered nerves in the prior art fail to achieve satisfactory therapeutic effects in terms of the above-mentioned key properties, and cannot solve the different needs of nerve growth factors at different stages in the growth process of the nerves to be repaired.

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