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Animal model of traumatic temporomandibular joint ankylosis and building method thereof

A technology of temporomandibular joint and animal models, applied in the field of animal models of traumatic temporomandibular joint ankylosis and its establishment, can solve the problems of lack of animal models, etc., and achieve the effect of easy breeding and rapid reproduction

Inactive Publication Date: 2016-04-13
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the anatomical structure of the temporomandibular joint in large animals is similar to that of humans, there is still a lack of animal models that can reflect the TTMJA trauma microenvironment and provide conditions for studying the underlying molecular or genetic mechanisms of TTMJA pathogenesis

Method used

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  • Animal model of traumatic temporomandibular joint ankylosis and building method thereof
  • Animal model of traumatic temporomandibular joint ankylosis and building method thereof
  • Animal model of traumatic temporomandibular joint ankylosis and building method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Sixty male C57BL / 6J mice of 1 month old were selected and randomly divided into two groups I and II, 30 mice in each group. The mice were intraperitoneally injected with 0.8% sodium pentobarbital for general anesthesia (100 μL / 10 g body weight). Then use 75% alcohol to disinfect the skin of the right preauricular area of ​​all mice. After disinfection, use small scissors to make a 1cm linear incision along the right preauricular skin to lift the parotid gland tissue to expose the facial nerve and accompanying blood vessels. Cut the preauricular fascia on the upper edge of the accompanying blood vessel, expose the zygomatic arch, avoid piercing the adjacent venous plexus, cut the nodular sac, expose the condyle, and use small scissors to remove part of the condyle cartilage of the temporomandibular joint on the right side of the group I mice And all the temporomandibular joint condyle cartilage (such as figure 1 The operation diagram is shown), and finally suture with 3-0 ...

Embodiment 2

[0046] Forty male C57BL / 6J mice of 1 month old were selected and randomly divided into two groups I and II with 20 mice in each group. The mice were injected intraperitoneally with 0.8% sodium pentobarbital for general anesthesia (100 μL / 10 g body weight). Then use 75% alcohol to disinfect the skin of the left preauricular area of ​​all mice. After disinfection, use small scissors to make a 1cm linear incision along the left preauricular skin to lift up the parotid gland tissue to expose the facial nerve and accompanying blood vessels. Cut the preauricular fascia on the upper edge of the accompanying blood vessel, expose the zygomatic arch, avoid piercing the adjacent venous plexus, cut the nodular sac, expose the condyle, and use small scissors to remove part of the condyle cartilage of the temporomandibular joint on the left side of group I mice And all the temporomandibular joint condyle cartilage on the left side of group II mice were finally sutured with 3-0 sutures. The mi...

Embodiment 3

[0048] Eighty 1-month-old male C57BL / 6J mice were randomly divided into two groups I and II, each with 40 mice. The mice were injected intraperitoneally with 0.8% sodium pentobarbital for general anesthesia (100 μL / 10 g body weight). Then use 75% alcohol to disinfect the skin of the right preauricular area of ​​all mice. After the disinfection is completed, use small scissors to make a 1cm linear incision along the right preauricular skin to lift the parotid gland tissue to expose the facial nerve and accompanying blood vessels. Cut the preauricular fascia on the upper edge of the accompanying blood vessel, expose the zygomatic arch, avoid piercing the adjacent venous plexus, cut the nodular sac, expose the condyle, and use small scissors to remove part of the condyle cartilage of the temporomandibular joint on the right side of the group I mice And all the temporomandibular joint condyle cartilage on the right side of group II mice were finally sutured with 3-0 sutures. The mic...

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Abstract

The invention discloses an animal model of traumatic temporomandibular joint ankylosis and a building method thereof. The building method includes: generally anesthetizing a young-age mouse, and using alcohol to disinfect skin at a preauricular position of the mouse, resecting part or all of temporomandibular joint condylar cartilage, and using the other side which is not treated as a control group; suturing after resection, and feeding soft food to the mouse within two weeks after operation to obtain the animal model of traumatic temporomandibular joint ankylosis. The animal model provides a condition for studying molecule or gene mechanisms of incidence of traumatic temporomandibular joint ankylosis and can also be used for studying application of medicine in preventing or treating the same.

Description

Technical field [0001] The invention relates to the technical field of animal pharmacology experiments, in particular to an animal model of traumatic temporomandibular joint ankylosis and a method for establishing it. Background technique [0002] Temporomandibular Joint Ankylosis (Temporomandibular Joint Ankylosis, TMJA) can affect mandibular movement, causing abnormalities such as restricted opening, difficulty in chewing, and language disorders. Traumatic injury is one of the important causes of temporomandibular joint ankylosis, and condyle trauma is the main cause of Traumatic Temporomandibular Joint Ankylosis (TTMJA). Epidemiological investigations suggest that multiple factors including age, fracture type, mandibular immobilization time, joint disc displacement, etc. can lead to the occurrence of TTMJA. At the same time, studies have shown that in 75% of TTMJA cases, there are residual condylar articular cartilage and articular discs, and the joint ankylosis only occurs o...

Claims

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Application Information

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IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 代杰文欧阳宁鹃沈国芳朱小芳王旭东史俊李洪亮
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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