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Method for producing porous cellulose particles, porous cellulose particles, and filler for chromatography

一种制造方法、纤维素的技术，应用在色谱阳离子交换剂、有机阳离子交换剂、阳离子交换材料等方向，能够解决成本或环境负荷有问题、不容易制成设备等问题，达到容易控制的效果

Active Publication Date: 2019-01-01
JNC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the method described in Patent Document 5 uses a highly harmful substance as a solvent for cellulose acetate
The method described in Patent Document 7 requires special equipment or special conditions
In addition, the method described in Patent Document 8 also melts filaments made of cellulose ester at a very high temperature, requiring special equipment
As such, conventional methods have problems in terms of cost and environmental load, so it is not easy to manufacture equipment under the present conditions

Method used

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  • Method for producing porous cellulose particles, porous cellulose particles, and filler for chromatography
  • Method for producing porous cellulose particles, porous cellulose particles, and filler for chromatography
  • Method for producing porous cellulose particles, porous cellulose particles, and filler for chromatography

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124]48.1 g of cellulose diacetate (Wako Pure Chemical Industries, Ltd., acetylation degree: 53% to 56%) was added to 352.5 g of 85% by weight aqueous acetic acid solution, and stirred. Furthermore, it heated up and stirred at 60 degreeC for 1 hour, thereby dissolving the cellulose diacetate, and obtaining the transparent solution whose diacetate cellulose density|concentration was 12 weight%. The solution was quickly injected into 1.5 L of o-dichlorobenzene at 100° C. containing 1.97 g of surfactant sorbitan monooleate, and stirred at 400 rpm for 10 minutes to obtain a dispersion system. Then, the dispersion system was cooled, and when it reached 30° C., 620 mL of pure water as a poor solvent was added dropwise. As a result, cellulose diacetate was precipitated to obtain spherical cellulose diacetate particles. Thereafter, the resulting cellulose diacetate particles were sufficiently washed with a large amount of methanol and then water. Next, the washed spherical cellulos...

Embodiment 2 and Embodiment 3

[0159] Porous cellulose particles were produced in the same manner as in Example 1, except that the concentration of cellulose diacetate in the cellulose diacetate solution was 10% by weight (Example 2) and 4% by weight (Example 3). The particle size distribution and Kav value of the obtained porous cellulose particles were measured in the same manner as in Example 1.

[0160] The results of Examples 1 to 3 are shown in Table 1 below. The Kav values ​​shown in Table 1 are values ​​in the case of PEG4120 (POLYMER LABORATORIES).

[0161] [Table 1]

[0162]

[0163] From Table 1, it can be said that the higher the concentration of cellulose diacetate, the larger the average particle diameter of the obtained porous cellulose particles tends to be. exist figure 1 The Kav values ​​of the porous cellulose particles obtained in Examples 1 to 3 are shown in . according to figure 1 It can be said that the higher the concentration of cellulose diacetate, the smaller the Kav value...

Embodiment 4

[0165] Porous cellulose particles were produced in the same manner as in Example 1, except that the concentration of cellulose diacetate in the cellulose diacetate solution was 10% by weight, and 620 mL of 50% methanol aqueous solution was used as a poor solvent. The particle size distribution and Kav value of the obtained porous cellulose particles were measured in the same manner as in Example 1.

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Abstract

The present invention provides a method for producing porous cellulose particles, porous cellulose particles, and a filler for chromatography. According to one embodiment, the method for producing porous cellulose particles includes: (a) dissolving cellulose diacetate In a solvent, prepare a cellulose diacetate solution; (b) disperse the cellulose diacetate solution in a medium that is not miscible with the cellulose diacetate solution to obtain a dispersion system; (c) disperse the cellulose diacetate solution cooling; (d) adding a poor solvent to the cooled dispersion system, thereby precipitating cellulose diacetate particles; and (e) saponifying the cellulose diacetate particles. In the present invention, porous cellulose particles can be obtained by a simpler method without using harmful solvents.

Description

technical field [0001] The present invention relates to a method for producing porous cellulose particles, porous cellulose particles, and a filler for chromatography. Background technique [0002] Porous cellulose particles are resistant to acidic solvents and basic solvents, and can be modified to add various substituents. Therefore, it is used as an adsorbent for various substances in a wide range of fields such as separation, purification, and desalination of various substances. The field of utilization of porous cellulose particles includes, for example, a gel filtration method (a method of classifying substances using a difference in molecular size). The gel filtration method can be applied to both aqueous solutions and organic solvents, and can be applied to compounds of any molecular weight. Therefore, it is widely used not only on a laboratory scale but also on an industrial scale (Patent Document 1). [0003] In addition, since porous cellulose particles have ex...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/14C08B3/06G01N30/88
CPCC08B3/06C08J3/14B01J39/22B01J39/26B01J20/24B01J20/285B01J20/3085C08L1/12C08J2301/12B01J39/05
Inventor 仓林彻青山茂之内田昭博
Owner JNC CORP
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