Barnidipine hydrochloride synthesis process
A technology of barnidipine hydrochloride and synthesis process, applied in directions such as organic chemistry, can solve problems such as low production efficiency, complex production process, low separation efficiency, etc., and achieve the effects of improving utilization rate, overcoming many processes, and improving work efficiency
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[0015] The synthesis process of barnidipine hydrochloride in this embodiment includes the following steps:
[0016] (1) 3-Hydroxypropionitrile (I) and diketene (II) are reacted in the presence of an organic base catalyst at a reaction temperature of 10°C, preferably 90°C, and a reaction time of 72h, preferably 3, to obtain compound (VI) ;
[0017] (2) The above compound (VI) reacts with m-nitrobenzaldehyde (III) in the presence of a protic or aprotic solvent, the reaction temperature is 5°C, preferably 70°C, and the reaction time is 72h, preferably 24h. Compound (VII);
[0018] (3) The above compound compound (VII) is reacted with ethyl β-aminocrotonate (IV) in a protic or aprotic solvent, the reaction temperature is 150°C, preferably 30°C, and the reaction time is 72h, preferably 1h, Compound (VIII) can be obtained;
[0019] "(4) The above compound compound (VIII) is hydrolyzed by a strong base in a protic or aprotic solvent, the reaction temperature is 150°C, preferably 70°C, and ...
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