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Application of peptide MDP-1 to preparing of anti-osteoporosis medicine

A technology for osteoporosis and MDP-1, applied in the field of biomedicine to achieve the effect of improving osteoporosis

Inactive Publication Date: 2016-05-11
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, MDP-1 was only reported for the first time in the Chinese patent application number CN201510796065.6, and the application of the peptide MDP-1 in the preparation of anti-infection, anti-endotoxemia and anti-sepsis drugs was proposed. There is no relevant report about the application of peptide MDP-1 in anti-osteoporosis therapy

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Embodiment Construction

[0027] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific experimental results.

[0028] In the previous work, the subject research team of the inventor of the present invention obtained a novel peptide MDP-1 consisting of 16 amino acids by means of chemical synthesis, the amino acid sequence of which is shown in SEQ.ID.NO.1. Through further research, the inventors of the present invention have detected that the peptide MDP-1 has a significant improvement effect on osteoporosis in ovariectomized mice, and further used the peptide MDP-1 for osteoclast differentiation experiments, and found that it can Inhibits osteoclast differentiation.

[0029] The amino acid sequence of the peptide MDP-1 studied in the present invention is as follows:

[0030] MRWQEMGYIFYPRKLR (same as SEQ.ID.NO.1)

[0031] The nucleotide sequence encoding said peptide MDP-1 is as follows:

[0032] ATGAGGTGGCAAGAAATGGGCTACATTTTCTACCCC...

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Abstract

The invention discloses an application of peptide MDP-1 to preparing of anti-osteoporosis medicine. The amino acid sequence of the peptide MDP-1 is shown in SEQ. ID. NO.1. According to the application, an in-vivo experiment shows that by means of the peptide MDP-1, the indexes such as the ratio of the mouse bone volume to the tissue volume, the thickness of bone trabeculaes and the numbers of the bone trabeculaes of an estrogen-deficiency osteoporosis model can be increased, the indexes such as the ratio of the bone surface area to the bone volume and the separation degree of the bone trabeculaes can be decreased, differentiation of osteoclast can be inhibited, and cytotoxicity is avoided; in this way, the peptide MDP-1 can be used for preparing anti-osteoporosis medicine, and particularly the peptide MDP-1 can be used for preparing anti-postmenopausal osteoporosis medicine.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of peptide MDP-1 in the preparation of anti-osteoporosis drugs. Background technique [0002] Osteoporosis is a clinically common metabolic bone disease syndrome. At present, there are about 200 million osteoporosis patients in the world, and there are 70-80 million in my country. Osteoporosis is divided into primary and secondary types. Postmenopausal osteoporosis (postmenopausalosteoporosis, PMOP) is the main type of primary osteoporosis, the fracture rate is about four times that of normal people, causing a heavy economic burden on patients, families and society. At present, the average life expectancy of Chinese women is prolonged, and postmenopausal osteoporosis is more serious. How to effectively treat osteoporosis, prevent its complications, and improve the quality of life of postmenopausal women is a major problem that needs to be solved a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61P19/10
CPCA61K38/10
Inventor 卢兹凡魏明卢环宇汪莉雷小英阮班军许承明姜英浩向安甘露
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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