Production method of hyperforin perforatum extract

A technology of Hypericum perforatum and its production method, which is applied in the field of production of Hypericum perforatum extract, and can solve the problems of not only increasing hypericin unilaterally

Inactive Publication Date: 2016-05-25
YAAN TAISHI BIOLOGICAL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods either unilaterally increase the content of hypericin, or focus on multi-component content
There is no method to improve the content of hypericin on the basis of ensuring the multi-component content of the product, so as to meet the quality requirements of the product in the international market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A production method of Hypericum perforatum extract, comprising the following steps:

[0033] (1) Raw material pretreatment: take the aboveground part of Hypericum perforatum, dry it until the water content is less than 10%, and then pretreat the product with an organic solvent after crushing; the particle size of the raw material after crushing is less than 2cm.

[0034] The specific steps of pretreatment are to add solvent oil to the raw material according to the ratio of 1:4, the temperature is 40°C, the extraction time is 3h, the solvent residue in the raw material is recovered after solid-liquid separation, and the solid raw material is used as a spare.

[0035] (2) Extraction: Add alkaline solvent to the pretreated raw material to adjust the pH value of the aqueous solution to 10 and extract with extractant. The weight ratio of the total solution of alkaline solvent and extractant to the raw material is 1:5, and the extractant accounts for the total solution. 60% ...

Embodiment 2

[0042] A production method of Hypericum perforatum extract, comprising the following steps:

[0043] (1) Raw material pretreatment: take the aboveground part of Hypericum perforatum, dry it until the water content is less than 10%, and then pretreat the product with an organic solvent after crushing; the particle size of the raw material after crushing is less than 2cm.

[0044] The specific steps of pretreatment are to add petroleum ether to the raw material at a ratio of 1:8, the temperature is 50°C, the extraction time is 2 hours, and the solvent residue in the raw material is recovered after solid-liquid separation, and the solid raw material is used as a spare.

[0045] (2) Extraction: Add alkaline solvent to the pretreated raw material to adjust the pH value of the aqueous solution to 13 and extract with the extractant. The weight ratio of the total solution of alkaline solvent and extractant to the raw material is 1:12, and the extractant accounts for the total solution....

Embodiment 3

[0052] A production method of Hypericum perforatum extract, comprising the following steps:

[0053] (1) Raw material pretreatment: take the aboveground part of Hypericum perforatum, dry it until the water content is less than 10%, and then pretreat the product with an organic solvent after crushing; the particle size of the raw material after crushing is less than 2cm.

[0054] The specific steps of pretreatment are to add diethyl ether to the raw material according to the ratio of 1:6, the temperature is 45°C, the extraction time is 2.5h, the solvent residue in the raw material is recovered after solid-liquid separation, and the solid raw material is used as a spare.

[0055] (2) Extraction: Add alkaline solvent to the pretreated raw material to adjust the pH value of the aqueous solution to 12 and extract with the extractant. The weight ratio of the total solution of the alkaline solvent and the extractant to the raw material is 1:8, and the extractant accounts for the total...

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PUM

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Abstract

The invention belongs to the field of Chinese herbal medicines, and particularly relates to a production method of a hyperforin perforatum extract. The method is characterized by comprising the following steps: pretreatment of raw materials, extraction, leaching, concentration and the like. The hypericin content in an extract product is improved on the basis of ensuring active ingredients of various components of the product.

Description

technical field [0001] The invention belongs to the field of Chinese herbal medicines, in particular to a production method of Hypericum perforatum extract. Background technique [0002] Hypericum perforatum, perennial herb. Up to about 1m high. The stem is erect, with many branches, and the branches are all axillary, with 1 raised longitudinal vein on both sides of the stem and branches. Simple leaves opposite; leaves sessile; leaf blade dense, elliptic to strip-shaped, 1-2cm long, 0.3-0.7cm wide, apex obtuse, base slightly clasping, entire, densely covered with transparent glandular spots. Cymes terminal; flowers larger, yellow; sepals 5, lanceolate, with sparse black glandular spots on the edge; petals 5, longer than sepals, with black glandular spots on the edge; stamens numerous, conjoined into 3 bundles, on anthers With black glandular spots; ovary superior, style 3-lobed. Capsule oblong, with dorsal glandular strips and lateral saclike glands. The flowering per...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185
CPCA61K36/185A61K2236/15A61K2236/17A61K2236/35A61K2236/39A61K2236/51
Inventor 郭军伟王顺尧马淑丽杨军陈彬
Owner YAAN TAISHI BIOLOGICAL SCI & TECH CO LTD
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