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Porous-fiber composite hemostatic material and preparation method thereof

A hemostatic material and porous fiber technology, applied in the field of biomedical hemostatic materials, can solve the problems of insufficient hemostatic speed, limited wide application, and unsatisfactory hemostatic effect, so as to shorten the time of hemostasis, accelerate the natural coagulation process, and reduce the risk of allergies Effect

Inactive Publication Date: 2016-05-25
广西达庆生物科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the hemostatic effect of these current technologies is not ideal, and the hemostatic speed is not fast enough, which limits its wide application in clinical practice.

Method used

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  • Porous-fiber composite hemostatic material and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] A porous fiber composite hemostatic material is composed of the following raw materials in weight percentage:

[0084] Microporous starch 20%

[0085] Collagen 40%

[0086] Puffball spore powder 20%

[0087] Hemostatic Chinese medicine extract 20%.

[0088] The surface pore diameter of the microporous starch is 6-15 μm, and the porosity of the microporous starch is above 90%.

[0089] The collagen is medical grade collagen with an average molecular weight of 1000 Daltons.

[0090] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 110 degrees Celsius, and passing through a sieve with a mesh size of 100 or more after crushing.

[0091] The hemostatic traditional Chinese medicine extract is a mixture of 10 parts of large thistle extract and 20 parts of small thistle extract.

[0092] The above-mentioned microporous starch, collagen, puffba...

Embodiment 2

[0094] A porous fiber composite hemostatic material is composed of the following raw materials in weight percentage:

[0095] Microporous starch 40%

[0096] Collagen 20%

[0097] Puffball spore powder 25%

[0098] Hemostatic Chinese medicine extract 15%.

[0099] The surface pore diameter of the microporous starch is 6-15 μm, and the porosity of the microporous starch is above 90%.

[0100] The collagen is medical grade collagen with an average molecular weight of 500 Daltons.

[0101] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 120 degrees Celsius, and passing through a sieve with a mesh size of 100 or more after crushing.

[0102] The hemostatic traditional Chinese medicine extract is a mixture composed of 20 parts of Burnet ulmus extract, 40 parts of Ramie root extract, 30 parts of Sophora japonica extract, 30 parts of Puhuang extract...

Embodiment 3

[0106] A porous fiber composite hemostatic material is composed of the following raw materials in weight percentage:

[0107] Microporous starch 30%

[0108] Collagen 25%

[0109] Puffball spore powder 20%

[0110] Hemostatic Chinese medicine extract 25%.

[0111] The surface pore diameter of the microporous starch is 6-15 μm, and the porosity of the microporous starch is above 90%.

[0112] The collagen is medical grade collagen with an average molecular weight of 2000 Daltons.

[0113] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 130 degrees Celsius, crushing and passing through a sieve of more than 100 mesh.

[0114] The hemostatic traditional Chinese medicine extract is 10 parts of Burnet extract, 20 parts of Rubia extract, 20 parts of Imperata rhizome extract, 10 parts of Cockscomb flower extract, 20 parts of Duanxueliu extract, 5 par...

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Abstract

The invention relates to a bio-pharmaceutical hemostatic material, in particular to a porous-fiber composite hemostatic material and a preparation method thereof. The porous-fiber composite hemostatic material is prepared from microporous starch, collagen, lasiosphaera seu calvatia spore powder and a hemostatic traditional Chinese medicine extract; the microporous starch has the effect of a molecular sieve and forms instant gel to block the blood vessel break; the collagen can be quickly combined with hemoglobin in blood to form hemostatic clots, and after being closely combined with a wound, the collagen can permeate into cambium and serve as a cell growth support; the three substances form a physical barrier to isolate the wound, and the effects of preventing adhesion and achieving instant hemostasis are achieved; the hemostatic traditional Chinese medicine extract has the effects of achieving hemostasis, resisting inflammation, resisting bacteria, achieving analgesia, cooling the blood, eliminating stasis to subdue swelling, restraining, activating a coagulation system and promoting wound healing. The four substances are organically combined, and the bio-pharmaceutical hemostatic material is significant in hemostatic effect, is used for wound surface errhysis of various wounds and fresh tissue, bleeding of small vessels and hemostasis of bleeding regions and adhesion prevention and is particularly suitable for hemostasis in a surgery.

Description

technical field [0001] The invention relates to the technical field of biomedical hemostatic materials, in particular to a porous fiber composite hemostatic material and a preparation method thereof. Background technique [0002] Hemostasis is an important link in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. The normal hemostasis mechanism mainly includes three aspects: the contraction of small blood vessels, the activation of platelets and the activation of the coagulation system. Among them, the contraction of small blood vessels is the earliest response to hemostasis after trauma. After the blood vessels are damaged, the smooth muscles of the blood vessels constrict the blood vessels and slow down the blood flow through axon reflex, which is beneficial to blood coagulation and hemostasis. Platelets have the physiological function of adhering to the surface of wounds and ...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/10A61L24/00
CPCA61L24/08A61L24/0005A61L24/0015A61L24/0036A61L24/102A61L2300/30A61L2300/404A61L2400/04
Inventor 梁奕福
Owner 广西达庆生物科技有限公司
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