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Traditional Chinese medicine composition combined with astragalus and turmeric for tumor radiation therapy and its preparation method and application

A technology of astragalus and turmeric, tumor radiation, applied in the direction of anti-tumor drugs, drug combinations, medical formulas, etc., can solve serious problems such as radiation reactions, achieve the effect of small toxic and side effects, reduce side effects and adverse reactions, and easy to obtain raw materials

Inactive Publication Date: 2019-12-06
SOUTHERN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the survival rate of tumor cells can be further controlled by increasing the local radiation dose, it will cause more serious radiation reactions, especially acute radiation reactions, such as skin reactions, mucosal reactions, parotid gland reactions and more serious systemic reactions

Method used

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  • Traditional Chinese medicine composition combined with astragalus and turmeric for tumor radiation therapy and its preparation method and application
  • Traditional Chinese medicine composition combined with astragalus and turmeric for tumor radiation therapy and its preparation method and application
  • Traditional Chinese medicine composition combined with astragalus and turmeric for tumor radiation therapy and its preparation method and application

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preparation example Construction

[0019] A preparation method of a traditional Chinese medicine composition preparation combined with astragalus and turmeric for tumor radiotherapy, which is characterized in that it comprises the following steps: (1) taking 8-16 parts of astragalus, 2-6 parts of turmeric, and 1-6 parts of black plum in parts by weight 3 parts, 0.5-1.5 parts of rhubarb are crushed into coarse powder; (2) Turmeric is extracted 2-4 times with water or 40-95% ethanol under reflux, each time adding water or alcohol is 5-15 times the amount of medicinal materials, and each time reflux extracts 1 ‐3 hours; (3) Astragalus, ebony, and rhubarb were boiled and extracted 2‐4 times with water, and the amount of water added each time was 5‐15 times that of the medicinal materials. The density is 1.10 / 80°C-1.30 / 80°C to obtain the water extraction extract of medicinal materials; (4) mix the extract with allowed pharmaceutical excipients, and make corresponding dosage forms by conventional methods.

[0020] Mi...

Embodiment 1

[0028] The ratio of parts by weight of astragalus, turmeric, black plum and rhubarb medicinal materials is 12:4:2:1. Astragalus, turmeric, black plum, and rhubarb are all crushed into coarse powder, decocted and extracted with water for 3 times, and the amount of water added each time is 5 times the amount of medicinal materials, and boiled for 1 hour. The combined extracts were filtered, evaporated and concentrated to a relative density of 1.10 / 80°C-1.30 / 80°C to obtain the water-extracted extract of medicinal materials.

Embodiment 2

[0030] The ratio of parts by weight of astragalus, turmeric, black plum and rhubarb medicinal materials is 24:8:4:2. Astragalus, turmeric, black plum, and rhubarb are all crushed into coarse powder, decocted and extracted with water for 3 times, the amount of water added each time is 10 times the amount of medicinal materials, and boiled for 2 hours. The combined extracts were filtered, evaporated and concentrated to a relative density of 1.10 / 80°C-1.30 / 80°C to obtain the water-extracted extract of medicinal materials.

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Abstract

The invention discloses a traditional Chinese medicine composition containing astragalus membranaceus and radix curcuma for assisting tumor radiotherapy, as well as a preparation method and an application thereof. The composition is prepared from the following components in parts by weight: 8-16 parts of astragalus membranaceus, 2-6 parts of radix curcuma, 1-3 parts of fructus mume and 0.5-1.5 parts of rheum officinale. The traditional Chinese medicine composition can be used for enhancing the sensitivity of tumor cells on radio-therapeutic ray, so that the curative effect of radiotherapy can be enhanced, the patient body can be nourished, and various side effects and adverse responses caused by radiotherapy can be reduced. Furthermore, the traditional Chinese medicinal materials are medicinal and edible medicinal materials, so that the traditional Chinese medicine composition has small toxic and side effects and simple and easily available raw materials and is convenient to take, so that physical and economic stress for patients can be greatly reduced.

Description

technical field [0001] The invention relates to a traditional Chinese medicine prescription for assisting tumor radiotherapy, in particular to a traditional Chinese medicine prescription and a preparation thereof which are combined with astragalus and curcuma to assist in enhancing the radiotherapy sensitivity of nasopharyngeal carcinoma tumors. Background technique [0002] Malignant tumors are diseases that seriously threaten human health. Due to the biological characteristics of tumor cells, as well as the differences in sensitivity and tolerance to different radiation, radiation therapy is often unsatisfactory. Although the survival rate of tumor cells can be further controlled by increasing the local radiation dose, it will cause more serious radiation reactions, especially acute radiation reactions, such as skin reactions, mucosal reactions, parotid gland reactions and more serious systemic reactions. For example, patients with nasopharyngeal carcinoma after radiothera...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P35/00
CPCA61K36/481A61K36/708A61K36/736A61K36/9066A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 范钦吕英李爱武邵萌朱道琦高玩皎黄沐刘钊汝
Owner SOUTHERN MEDICAL UNIVERSITY