Combinations of anti-pd-l1 antibody and mek inhibitor and/or braf inhibitor

Abstract

A novel combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro- 4-iodo-phenylamino)6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3- d]pyrimidin-1 -yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and / or a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1 - dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and an anti-PD-L1 antibody; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and / or B-Raf and / or neutralizing or inhibiting the interaction between PD-L1 and its receptor, e.g. PD-1, is beneficial, eg. cancer.

Description

technical field [0001] The present invention relates to methods of treating cancer in mammals and to combinations useful in such treatment. In particular, the method involves novel combinations comprising a MEK inhibitor, suitably N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6, 8-Dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide or A pharmaceutically acceptable salt or solvate thereof, and / or a B-Raf inhibitor, suitably N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethyl ethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and an anti-PD-L1 antibody; comprising the combination and methods of using such combinations and compositions to treat disorders, such as cancer, in which inhibiting the interaction of MEK and / or B-Raf and / or PD-L1 with a molecule that binds it, such as PD-1, is benefit. Background technique [0002] Effective treatment of hyperproliferative dise...

AI Technical Summary

Problems solved by technology

Thus, although there is a primary antitumor immune response in many cases, the functional, effector antitumor T cell response is usually weak at best

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