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Preparation and application of myrobalan element molecular imprinting polymerization new material

A technology of molecular imprinting and chebulin, which is applied in the field of pharmaceutical chemical engineering, can solve the problems of unfriendly environment, high cost, complex extraction and separation process of chebulin, etc.

Inactive Publication Date: 2016-06-15
刘庆山
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the extraction and separation process of chebulin is complex, expensive and environmentally unfriendly, so it is of great significance to find new methods to quickly separate and purify chebulin and its structural analogues from crude extracts of traditional Chinese medicines

Method used

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  • Preparation and application of myrobalan element molecular imprinting polymerization new material
  • Preparation and application of myrobalan element molecular imprinting polymerization new material

Examples

Experimental program
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Effect test

Embodiment

[0007] Precisely weigh 6 portions of 30.0 mg each of the synthesized chebulin MIPs and NIPs, place them in 10 mL volumetric flasks, add different concentrations (10-60 μg / mL) of chebulin-acetonitrile aqueous solution 3 mL, airtight, and keep at constant temperature Shake and absorb on a shaker for 12 hours, let it stand still, absorb the supernatant, and detect the concentration change of the template molecule chebulin in the solution with an ultraviolet spectrophotometer. Calculate the adsorption amount of the molecularly imprinted polymer according to the concentration change of the template molecule chebulin in the solution before and after adsorption, and perform Scatchard analysis, the results are as follows figure 2 . From figure 2 It can be seen that the adsorption capacity of chebulin MIPs is significantly higher than that of its corresponding NIPs, indicating that MIPs have selective adsorption capacity for target molecules, while NIPs do not. Calculation of the m...

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Abstract

The invention discloses a molecular imprinting material targeting separation myrobalan elements and a method for separating and purifying myrobalan elements and perfect analogons of the myrobalan elements in a natural product by taking the material as a solid-phase extraction agent. The material is composed of nanoscale microballoons, the electric mirror image surfaces of the microballoons are smooth, particles are uniform, the targeting adsorptive property is good, the material belongs to a novel separation material, can serve as a solid phase of a solid-phase extraction column and can be used for efficiently separating and gathering the myrobalan elements and the structural perfect analogons from traditional Chinese medicine crude extract in an orientation mode, and in this way, the extraction efficiency of target components can be improved, operation is easy and convenient, environment friendliness is achieved, the amount of chemical reagents can be reduced, and the application prospects of the material are good.

Description

Technical field: [0001] The patent of the present invention relates to a method in the technical field of medicinal chemical engineering, and specifically relates to the preparation of a molecularly imprinted material of chebulin and a method for using the material to separate and purify chebulin and its structural analogues from crude extracts of traditional Chinese medicines. Background technique: [0002] Myrobalan is the dry and mature fruit of the Junzi family plant Myrobalan (Terminaliachebula Retz.), known as the king of Tibetan medicine, called Heli in "Synopsis of the Golden Chamber", and called Heli in "Qian Jin Fang". It is called Suifengzi in "Chuanxin Fang", and it is widely used in various ethnic medicines, especially in Tibetan medicine and Mongolian medicine. Myrobalan (alias Tibetan Qingguo, Helile; Mongolian medicine name "Arula") is one of the three fruits of Tibetan medicine, which was first recorded in the Tibetan medical book "Yuewang Medicine Diagnosis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F226/06B01D15/08
CPCB01D15/08C08F222/14C08F222/145C08F226/06
Inventor 刘笛刘庆山张伟伟
Owner 刘庆山