Poria cocos formula granule preparation method and application
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A technology of formula granules and tuckahoe, which is applied in the field of preparation of tuckahoe formula granules, can solve the problems of affecting application, many impurities, large patient dosage, etc., and achieve the effects of inhibiting proliferation, reducing the number of growth, and high content of active ingredients
Inactive Publication Date: 2016-06-22
南京多宝生物科技有限公司
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However, the current extraction methods are backward, so far, people are looking for an effective extraction method for formula granules
In the prior art, there is no report on the use of microwave technology in the extraction and preparation of Poria cocos-containing formula granules. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the This product is used clinically
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Embodiment 1
[0014] Example 1: Take 200g of Poria cocos, crush it, add 2L of 70% ethanol, put it into a microwave extraction device for microwave extraction, the extraction power is 400W, extract twice, each time 8 minutes, combine the extracts, concentrate, add to D101 On a macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain the microwave extract, which is Poria formula granules.
Embodiment 2
[0015] Example 2: Take 200g of Poria cocos medicinal material, crush it, add 2L of 70% ethanol, put it into a microwave extraction device for microwave extraction, the extraction power is 600W, extract twice, each time for 4 minutes, combine the extracts, concentrate, add to D101 On a macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain the microwave extract, which is Poria formula granules.
Embodiment 3
[0016] Example 3: Take 200g of Poria cocos medicinal material, crush it, add 2L of 70% ethanol, put it into a microwave extraction device for microwave extraction, the extraction power is 500W, extract twice, each time for 6 minutes, combine the extracts, concentrate, add to D101 On a macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain the microwave extract, which is Poria formula granules.
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Abstract
The invention provides a poria cocos formula granule preparation method. The preparation method comprises the following steps that 200 g of poria cocos medicinal materials are taken, smashed and added to 2 L of 70% ethyl alcohol, and the mixture is put into a microwave extracting device for microwave extracting, wherein the the extracting power ranges from 400 W to 600 W; extracting is conducted twice, each time lasts 4-8 min, extracts are combined, concentrated and added to a D101 macroporous adsorption resin column, elution is conducted with 50% ethyl alcohol, eluent with the volume five times that of a measuring column is collected, vacuum recycling is conducted on ethyl alcohol, concentration and drying are conducted, microwave extracts are obtained, and the microwave extracts are poria cocos formula granules; the content is greatly improved, and the dosage is reduced. The invention further provides application of a plant composition containing the poria cocos formula granules in preparing drugs for inhibiting human macrophage lymphoma U937 cell proliferation.
Description
technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Poria formula granules. Background technique [0002] Traditional Chinese medicine formula granules are granules made by extracting and concentrating single-flavored Chinese medicine decoction pieces, and are used for clinical formulas of traditional Chinese medicine. It used to be called single-flavor Chinese medicine concentrated granules in China, and its trade name and folk appellation also include decoction-free Chinese medicine slices, new slices, refined slices, beverage-type slices, scientific Chinese medicine, etc. It is a new type of medicine with unified specifications, unified dosage and unified quality standards, which is made from traditional Chinese medicine decoction pieces as raw materials through extraction, separation, concentration, drying, granulation, packaging and other production pro...
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