79results about How to "Many impurities" patented technology

The invention relates to the technical field of polypeptide synthesis, in particular to a preparation method of semaglutide. The preparation method comprises the following specific steps: A) synthesizing a pentapeptide fragment (compound I) by a liquid phase method; B) in the presence of an activator system, coupling a solid-phase resin carrier and FmoC-Gly-OH to obtain FmoC-Gly-resin; C) by a solid-phase synthesis method, sequentially coupling amino acids with FmoC protections at N terminals and side chain protections according to a peptide sequence of a main chain of the semaglutide, wherein the lysine is the pentapeptide fragment (compound I); D) cracking, purifying and freeze-drying peptide resin to obtain the semaglutide. The invention provides a synthesis process of the semaglutide, which is short in synthesis period, low in cost and high in yield and is suitable for mass production.

The invention discloses a method for preparing and transferring a graphene transparent film. The technical problem required be solved is that impurities, cracks and bumps after the graphene transparent film is transferred are required to be reduced. The preparing and transferring method disclosed by the invention comprises the steps of: carrying out chemical vapor deposition on the graphene film on a metal substrate, coating methyl methacrylate or photoresist to form a support layer; electrolyzing the graphene film and separating the metal substrate; and coating the methyl methacrylate or photoresist on the support layer, putting the support layer into acetone solution, and attaching the graphene film to an appointed substrate. Compared with the prior art, the film composed of the graphene film and the support layer is separated from the metal substrate by an electrochemical foaming method; the graphene film is transferred to an appointed substrate and then the graphene film well contacts the plane of the appointed substrate without the cracks by spin coating for second time; the metal substrate can be repeatedly used, and the cost of preparation of the graphene transparent film is reduced; the transferred graphene film is well contacted with the substrate, and the impurities are relatively few.

The invention relates to a method for preparing epoxy chloropropane which is obtained through successive reaction and distillation coupling technology after glycerine that is the by-product of biological diesel oil reacts with chlorine hydride through substitution reaction under homogeneous multielement catalysis and further performs saponification cyclization reaction. The method comprises the following steps: (1) chlorine hydride is pumped in glycerine that is the by-product of biological diesel oil for reaction under homogeneous multielement catalysis, and the mixture composed of 1, 3-dichloro-2-propanol and 2, 3-dichloro-1-propanol is prepared through the technologies of continuous feeding, continuous catalyzed chlorination and continuous rectification; (2) the isomeride mixture solution of 1, 3-dichloro-2-propanol and 2, 3-dichloro-1-propanol performs the saponification cyclization to generate a product of epoxy chloropropane in alkaline solution. The method has the advantages of mild reaction condition is mild, high catalyst activity, dedicated catalytic performance, high product selectivity, process 'cleaning', easy separation, continuous operation, environment-friendliness, etc.

A horizontal and super combined beehive comprises a wide-comb box, a frame support, a powder-releasing cover, a pollen box, a connector, a degummed drape, an inserted frame, an integrated frame and a wax comb foundation with suspension loops. The wide-comb box is characterized in that the both ends of the box are used as the breeding areas for two swarms of bees, a super is supported above the middle production area, frame queen excluders are used to form a working bee centralized production area, the areas are covered; the powder-releasing cover is bottomless, pollens and honey on a powder-leaking railing pedal with anti-theft gantry boxes on both sides directly leak in the pollen box at the bottom; the connected box is coarsely adjusted by a multi-teeth hook and finely adjusted and connected firmly by a screw crow bar through screws; the laps and edgings of the inserted frame are integrated, an upper beam and a lower beam are inserted in the upper and lower grooves of two edgings to integrate, the upper beam is thin, the lower beam and the edgings are provided with grooves to be inserted in the comb foundation; a wide hook with the same width and an adjuster are hung on the wax comb foundation for tightening; the laps are integrated with a frame-distance clip and connected with the upper beam through a downward slope, the tops of comb-forming frame supports are butted to each other and are tightly pressed by the degummed drape and the inner frame of the box cover, the distance of the frames is standard so that people can not stung by bees; and the top of each lap is provided with a handle, thus the laps can be fast gripped outside the box. The wide-comb box can be used to multiply the efficiency, thus being suitable to be used for beekeeping around the world.

The invention comprises a convenient beehive consisting of a nest frame support, degummed covering cloth, a powder-removing cover, a pollen box, a connector, a plug-in nest frame, an integrated nest frame and a wax nest foundation with hanging rings, and is characterized in that the powder-removing cover is erected on a box leak powder grate pedal, and pollen and honey water are leaked into the pollen box at the bottom part via a powder grate; the beehive is connected in a multi-tooth hook group for rough adjustment, and a thread of a spiral crowbar is used for fine adjustment and tight prying; the nest frame is integrally formed, laps of the plug-in nest frame are integrated with edge strips, the upper and the lower hanging rings at two ends of the was nest foundation are hung on wide hanging hooks in two edge strip bare cover type mouths, an upper beam and a lower beam are also tightened when being inserted in an upper groove and a lower groove of two edge strips, and a regulating buckle which is not tightened is buckled in the group; the upper beam is thin, the grooves are formed on the edge strips and the lower beam for mounting a plastic nest foundation; the laps are integrated with a frame distance clamp, a lower slope is connected with the upper beam, a frame and the top part of the nest frame support push against each other and compressed by a bee separating plate and a cover frame without gaps, and the frame distance is standard and difficult to kill bees due to extrusion and avoid the bees from stinging people; pull handles are arranged at the top ends of the laps, thereby being convenient to grab outside the beehive; and the degummed covering cloth with holes is used for covering the bees, thereby collecting more gum and realizing fast degumming. The convenient beehive can improve the effectiveness by a plurality of times and is applicable to world beekeeping.

The invention relates to a saw web used for both cutting and grinding. The saw web comprises a saw web body, double-layer cutter heads, tooth backs and a grinding wheel. Grooves are formed in the positions, on the same sides of the tooth backs, of the saw web body. The double-layer cutter heads are welded in the grooves. The grinding wheel comprises an upper grinding wheel body and a lower grinding wheel body. The upper grinding wheel body and the lower grinding wheel body are annular and arranged on the both sides of the saw web body correspondingly. The saw web body, the upper grinding wheel body and the lower grinding wheel body are provided with bolt through holes in fit with one another. The upper grinding wheel body and the lower grinding wheel body are fixed to the saw web body through bolts. By adoption of the saw web used for both cutting and grinding, a cut surface can be cut and ground at the same time, the efficiency is greatly improved, the flatness of the ground surface is improved, and the perpendicularity of the ground surface and a profile is improved; and meanwhile, by designing the embedded cutter heads, the impact resistance of saw web cutter teeth of the saw web to to-be-cut materials during cutting is greatly improved, and the cutter heads are not prone to falling off.

The invention relates to art oil paint with nano-pigment and the preparation method, which is characterized in that the beeswax is added into refined linseed oil and polly seed salad oil and blended evenly to make bond after heating and melting. The nano-pigment is added into the bond to blend evenly and then the pigment is added in and blended evenly. Then aluminum stearate, 2-ethyl hexanol cobalt (CAS No.13586-82-8), silicon dioxide hydrate, hydrafil, phenoxetol, butyl-p-cresol and lithopone are added in and then blended evenly. The product can be obtained after grinding. The preparation method first disperses the nano-pigment into the bond and drains most air on the surface of the common pigment grain, and then disaggregates the large grain and small gobbet of the sizing agent by the large shearing force, extrusion force and grinding force between the two rollers generated by the turn of the three-roller muller. During the grinding process, the bond with nano-pigment or latex covers the surface of the pigment grain and then permeates through the gaps of the grains. The product made has the advantages of rich color, bright colour and luster, fresh tint, strong tinctorial strength and good chromaticity.

The invention provides a novel synthetic process of high-purity florfenicol. The process comprises the following steps: by taking a compound D-threo form-2-(dichloromethyl)-4,5-dihydro-5-[p-(methylsulfonyl)phenyl]-4-oxazole methanol as an initial raw material, carrying out fluoro-substitution by using an Ishikawa reagent; crystallizing and purifying to obtain a high-purity fluoro product (4S,5S)-2-(dichloracetyl)-4-(methyl fluoride)-5-[4-(methylsulfonyl)phenyl]-4, 5-dihydrooxazole; and further carrying out a hydrolysis reaction directly on the high-purity fluoro product without being added into an organic solvent to directly obtain a high purity florfenicol product. According to the production process, the fluoro intermediate product is crystallized and purified to obtain a high purity product by adopting a direct hydrolysis process without using the organic solvent, so that the novel synthetic method is simple in process operation, environmental friendly, high in product purity, few in impurity, free from solvent residue and low in cost.

The invention discloses a novel preparation method of Fe-MOF (ferrous-metal oxide framework) and an application thereof in desulfurizing field. The preparation method comprises the following steps of adopting an electrochemical method, using a metal element of Fe (iron) as an anode, and using 66.7 to 80vol% ethanol solution as an organic solvent; using an anode dissolving method to enable the dissolved-out Fe3+ ion and the H3BTC in an electrolyte solution to generate coordination reaction, so as to generate a sample; washing and drying the sample, so as to obtain the FeBTC catalyst. The preparation method has the advantages that the mixing of anion ion impurities of metal salt is avoided, the prepared sample is pure, the synthesis condition is moderate, the reaction is quick, and the reaction time is short; the prepared Fe-MOF catalyst is applied into medium-low temperature hydrolysis reaction of carbonyl sulfide, the activity and stability are good, and a novel COS (carbon oxysulfide) hydrolysis catalyst is developed.

The invention discloses a method for using waste oil and grease as raw material to prepare fatty acid methyl ester. The method mainly comprises the steps of raw material oil preprocessing, esterification workshop section, ester exchange, coarse methyl ester rectification, washing and glycerinum purification and recovery. The utilization rate of raw material oil is high, and the water and sediment content of raw material oil is not limited. The coarse alkyl ester rectification efficiency of a rectification system is improved by adding boric acid. On the premise that the raw material requirement is net and by the adoption of process treatment, the conversion rate of drainage oil and swill oil is 86-87%, the conversion rate of fatty acid is 92-93%, and the processing cost is low (700-800 yuan / ton). The method is suitable for industrial fatty acid methyl ester preparation.

Zaleplon can be separated from a regioisomer impurity by crystallization from selected solvents or by adding an anti-solvent to a solution of zaleplon and the regioisomer. Zaleplon crystalline Forms II, III, IV, and V are useful for the treatment of insomnia. These crystalline Forms are described along with processes for making them v crystallization from selected solvents.

The invention provides efficient and effective processes for recovering metals such as aluminum, magnesium and lithium from mixed waste sources such as auto shredder residue, aluminum cans, waste particles of aluminum alloy and municipal waste. The metal-waste source is dissolved in a more noble metal solvent at a temperature at which contaminants do not dissolve. The purified metal is then recovered from the solvent, preferably by electrorefining.

A turbo machine having a rotor and a stator is at least partially provided on a flow-guiding part with a catalytic coating. The catalytic coating (7, 7′) comprises at least one oxide of a transition metal or an oxide of a mixture of transition metals, wherein the transition metals are elements from groups I B, in particular Cu, Ag, Ag, II B, in particular Zn, Cd, Hg, III B, in particular Sc, Y, IV B, in particular Ti, Zr, Hf, V B, in particular V, Nb, Ta, VI B, in particular Cr, Mo, W, VII B, in particular Mn, Tc, Re and / or VIII B, in particular Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt.

The invention belongs to the technical field of synthesis chemical drugs, and particularly relates to a synthesis method of chidamide. The method comprises the following steps: carrying out reaction on 3-(3-pyridyl)acrylamide and 4-(bromomethyl)benzoic acid to obtain an intermediate N-(methyl-4-benzoic acid)-3-pyridyl acrylamide, and carrying out reaction on the N-(methyl-4-benzoate)-3-pyridylacrylamide and 3,4-diaminofluorobenzene, thereby obtaining the chidamide. The synthesis method overcomes the defects of low product purity and multiple impurities in the prior art. The method has the characteristics of mild conditions, high controllability, high product purity and fewer impurities, and basically satisfies the requirements for green chemistry.

The invention discloses a semiconductor silicon abraded wafer cleaning agent and a preparation method thereof. The cleaning agent is prepared from a surface active agent, organic alkali, complexing agent, cosolvent and water. The cleaning agent is prepared from the following ingredients in percent by volume: 1 to 15% of the surface active agent, 3 to 5% of the organic alkali, 2 to 10% of the complexing agent, 3 to 10% of the cosolvent and 60 to 80% of the water. The cleaning agent prepared from the ingredients in percent by volume has advantages of simpleness in silicon wafer cleaning operation, no complex cleaning step, low cost, no pollution and special suitability for cleaning silicon carbide abraded silicon wafers.

The invention relates to a preparation method and application of an organic sulfur conversion catalyst. With use of an electrochemical synthesis method, metal ions dissolved through an anode and an organic ligand 1,3,5-benzenetricarboxylic acid in a solution are self-assembled to form a metal-organic framework material (MOF). The method can avoid introduction of metal salt anionic impurities, the synthesis conditions are mild, the reaction is rapid, and the consumed time is short. The preparation of the catalyst is simple and convenient and comprises the steps: taking a metal Cu elementary substance as an electrode, placing in an ethanol-water solution containing the 1,3,5-benzenetricarboxylic acid (H3BTC) organic ligand and a tetrabutylammonium perchlorate (TBAP) support electrolyte, communicating a circuit, carrying out an electrolytic reaction, and thus generating a pure Cu-MOF (HKUST-1) material. The prepared HKUST-1 has an octahedral structure, has the advantages of geometric symmetry, high utilization ratio and relatively high catalytic activity at a temperature of 150 DEG C, and is suitable for medium-low temperature catalytic hydrolysis of carbonyl sulfide gas.

The process of separating and purifying 1, 3-propylene glycol of fermented liquid in a four-area simulating mobile bed includes the following steps: 1. filtering and ultrafiltering the fermented liquid of 1, 3-propylene glycol to eliminate cell, thallus, solid matter and protein and lower the viscosity of the material liquid; 2. decolorizing the filtered fermented liquid; and 3. separating 1, 3-propylene glycol liquid of 5-40 g / l concentration in a simulating mobile bed system with cationic exchange resin, eluting with pH 2-14 deionized water, and collecting 1, 3-propylene glycol in high purity and impurity from different ports. The present invention separates and purifies target product by means of the physical, chemical and biological differences between the target product and the impurity, and has high preparing efficiency and high product purity.

The invention relates to wallpaper, in particular to wallpaper prepared by taking loofah as a raw material. The method comprises the following steps: (1) softening the loofah; (2) bleaching the loofah; (3) preparing loofah short fibers and a loofah fiber thin film; (4) preparing a thin fiber net; (5) compounding the loofah fiber thin film with the thin fiber net obtained by using a carding machine, and then sending the product into a needle machine for needling so as to obtain a needled punched nonwoven material, namely, the wallpaper prepared from the loofah fibers. The prepared wallpaper is better in mold prevention performance and moisture resistance, and has a certain odor absorption property.

A method of manufacturing high purity fiber cement grades of cellulose fibers is described. Additional washing steps, coupled with an elevated temperature, are used in the process to extensively wash the pulps and remove substantially all COD components remaining in the pulps. The pulps are counter-currently washed by diffusion and dewatering at elevated temperatures following the brown stock washer systems. During the additional washing steps, the pulps are soaked in counter-current heated water for a pre-determined time and some chemicals may be introduced to chemically break down the COD components in the pulps and to make them more soluble in the aqueous solution. The additional washing steps can be performed using existing equipment at conventional pulp mills. A formulation and a process of making fiber reinforced cement composite materials are also described using the low COD and high purity cellulose fibers. The pulps with lower COD contents have superior performance in manufacture of fiber reinforced cement composite materials. A smaller amount of the low COD and high purity fibers is needed to achieve the same reinforcement efficiency, compared to regular cellulose fibers.

A system and method for determining impurities in a beverage grade gas such as CO2 or N2 relies on a coupling of FTIR analysis and UV fluorescence detection. Conversion of reduced sulphur present in some impurities to SO2 can be conducted using a furnace. In some cases, CO2 % also is determined.

The invention discloses a degradable bacteriostatic soft cotton tissue and a preparation method thereof, and particularly relates to a tissue made by taking loofah sponge fibers, cotton fibers, chitosan and polyvinyl alcohols as raw materials. The degradable bacteriostatic soft cotton tissue is prepared through the following steps of: (1) carrying out mercerization preprocessing on a loofah sponge; (2) bleaching the loofah sponge; (3) preparing a loofah sponge fiber solution; (4) carrying out mercerization preprocessing on the cotter fibers; and (5) preparing a chitosan fiber solution; and (6)mixing each above solution, adding the polyvinyl alcohol, fully stirring to form a spinning solution, and obtaining the soft cotton tissue through a electrospinning technology. After the soft cottontissue is prepared, the soft cotton tissue is segmented into a plurality of small pieces by hand shredding lines, wherein two ends of each hand shredding line are independently provided with a notch.The soft cotton tissue prepared by the invention is light, thin, soft, skin-friendly and comfortable, has ultrahigh moisture absorption and water locking performance, also has good oil absorbency andheavy metal ion absorption performance, and has good antibacterial properties, and the adopted materials are environmentally friendly and belong to naturally degradable materials.

The invention provides <13>C marked pyraoxystrobin and a synthetic method thereof, and relates to the technical field of stable isotope labelling synthesis. The synthetic method of the <13>C marked pyraoxystrobin provided by the invention comprises the steps that chlorobenzene is used as a raw material; through acylation reaction and condensation cyclization reaction, a first product is obtained;O-methylphenylacetic acid methyl ester is subjected to condensation reaction, methylation reaction and bromination reagent reaction to obtain a second product; the first product and the second productreact in alkaline environment to obtain the <13>C marked pyraoxystrobin. The operation process of the synthetic method provided by the invention is simple; the stable isotope atom utilization rate ishigh. The <13>C marked pyraoxystrobin synthetized by the synthetic method provided by the invention has the advantages that the separation and the purification are easy; the product chemical purity reaches 98 percent or higher; the isotope abundance is 98 percent or higher.

The invention relates to a technology for synthesizing liraglutide, which solves the problems of long synthesis period, high cost, low yield and many impurities in the prior art. The specific steps of the present invention are: A) synthesis of fragment Fmoc-Lys-(Glu(Nα-Palmitoyl)-OtBu)-OH through liquid phase; ‑OH coupling to obtain Fmoc‑Gly‑resin; C) By solid phase synthesis, amino acids with N-terminal Fmoc protection and side chain protection are sequentially coupled according to the peptide sequence of liraglutide main chain, in which the lysine tripeptide fragment Using Fmoc‑Lys‑(Glu(Nα‑Palmitoyl)‑OtBu)‑OH; D) to cleavage, purify, and lyophilize to obtain liraglutide. The invention provides a synthesis process of liraglutide with short synthesis period, low cost, high yield and suitable for large-scale production.

The invention discloses a liquid culture medium for submerged bamboo fungus fermentation. The liquid culture medium consists of the following components: 20-24g of beet molasses, 5-9g of soybean cake powder, 40-50mL of pig manure extracting solution, and the balance of water which is added to 1000mL. The preparation method comprises the following steps: mixing the various components, performing high-pressure steam sterilization at the temperature of 121 DEG C for 15-25 minutes, and cooling, thereby obtaining the liquid culture medium. The pig manure is matched with the other components so as to prepare the culture medium, the requirements on submerged bamboo fungus fermentation can be met, nutritional ingredients of waste animal residue extracting solution are fully utilized, and the price is low.

The invention discloses an extracting method of effective ingredient of fire fruit series, which comprises the following steps: removing impurity, squeezing after cleaning, immersing to extract through acid low-grade alcohol, filtering, proceeding column chromatographic purifying, drying to obtain red coloring matter, adopting alcohol or acetone to extract fruit residual, filtering, recycling solvent, extracting, purifying, drying to obtain yellow coloring matter, utilizing alcaine to hydrolyze fruit residual, filtering, condensing, decolouring, sedimenting, purifying, drying to obtain pectin, making residuals as raw material of feed.

The invention discloses a method for separating and purifying dehydroevodiamine from fructus evodiae which is a rutaceous plant. The method comprises the following steps: soaking a fructus evodiae fruit by using a petroleum ether to degrease, then extracting with 2% HCl as a solvent through a reflux extraction method, collecting an extracting solution, then carrying out vacuum concentration or freeze-drying to obtain an extractum A, dissolving the extractum A with methyl alcohol, filtering, carrying out vacuum concentration or freeze-drying on a filtrate to obtain an extractum B, taking polyamide resin as a filler to elute the extractum B with water-ethyl alcohol, fractionally collecting a semi-finished product, conducting vacuum concentration or freeze-drying to obtain a solid semi-finished product, taking ethyl alcohol-acetone as a solvent to recrystallize the solid semi-finished product to obtain a dehydroevodiamine powder crystal with the purity more than 98.5%. The yield of the dehydroevodiamine prepared through the method is high, the cost is low, the operation is simple, and the method is environmentally friendly, and is suitable for large-scale industrial production.

The invention discloses a preparation method of herba centellae substitutional tea. The preparation method comprises the steps of (1) collecting: collecting centella leaves in two seasons of summer and autumn; (2) cleaning and selecting: removing foreign matters, branches or yellow leaves; (3) spreading for cooling: ventilating and spreading for cooling the centella at 26 to 30 DEG C; (4) de-enzyme: performing de-enzyme treatment on the centella leaves; (5) molding: putting raw materials after de-enzyme on rolling equipment, spreading for cooling firstly, then rolling to obtain strip decoction pieces; (6) drying: drying the rolled leaves under the condition that the temperature is 50 to 110 DEG C and the thickness is 1.0 to 3.0 cm, and the drying time is 1 to 2h; (7) controlling the humidity of the dried herba centellae substitutional tea to below 60 percent, and cooling the dried herba centellae substitutional tea to room temperature, and then performing subpackage to obtain a finished product. According to the preparation method of the herba centellae substitutional tea, all aspects such as the purity of materials, sensation of sense organs of the color, shape, smell and the like of the tea, the mobility of yield production, moisture and ash content, the content of active ingredients, long-term stability, brewing property of the decoction pieces, and the like are obviously superior to that of the existing technical scheme.

The invention discloses a wide-spectral-response soft bismuth ore-based efficient photocatalyst and a preparation method thereof, and belongs to the field of environmental science and inorganic material preparation. The novel broad-spectrum-response soft bismuth ore-based photocatalyst Bi[24](Bi[2-x]Co[x])O[39+x] (x is greater than 0 and less than or equal to 1) for efficient photocatalytic degradation of organic pollutants is prepared by adopting a hydrothermal method, specifically, bismuth salt and cobalt salt are dissolved in alkali liquor with a specific concentration, and hydrothermal reaction is carried out at a relatively mild temperature for a relatively long time, so that the photocatalyst Bi[24](Bi[2-x]Co[x])O[39+x] is prepared. The preparation method provided by the invention islow in cost, simple in process and easy to control, and provides a new preparation idea for preparation of other soft bismuth ore photocatalysts with similar structures; the obtained catalyst has thecharacteristics of narrow energy gap, good crystallinity and high purity, shows good visible light catalytic degradation activity on organic pollutants in water such as dyes, phenols and the like, and has a wide potential application prospect in the field of visible light organic pollutant degradation.

The invention discloses a method for preparing 3-fluorooxetane-3-methanol and an intermediate of 3-fluorooxetane-3-methanol. The method comprises the following steps of: performing a cyclization reaction on a compound represented by a formula 5 and strong base in organic solvent so as to obtain a compound represented by a formula 6, wherein R1 is a methylsulfonyl group or a p-methylphenylsulfonylgroup or a p-trifluoromethylbenzenesulfonyl group or a trifluoromethylsulfonyl group; preforming a reaction on magnesium and the compound represented by the formula 6 in organic solvent so as to obtain a compound 7. The method has the advantages of being high in yield, simple to operate and simple in post-treatment, and is suitable for large-scale production.