Application of Yiganle tablet to preparation of drugs for inhibiting mast cell leukemia cell CHMas proliferation

A technology of leukemia cells and mast cells, which is applied in the field of preparation of Yiganle Tablets, can solve the problems of rough, backward and large dosage of patients, etc.

Inactive Publication Date: 2016-07-06
JINAN XINSHIDAI MEDICINE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the application of Yiganle tablets in the preparation of drugs for inhibiting the proliferation of human mast cell leukemia cells CHMas cells, and there is no report on the use of supercritical extraction in the extraction and preparation of Yiganle tablets. The method of decocting in water and ethanol reflux extraction, the process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 200g of chicken vine, 160g of Polygonum cuspidatum, 200g of verbena, 200g of June snow, 200g of Malan grass, 200g of Mao berry, 170g of auspicious grass, 100g of Gonggong wood and 70g of cold water flower, and add it to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 750min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.30g.

[0025] After testing, the content of emodin in the finished product is 1.85mg / tablet.

Embodiment 2

[0027] Take 200g of chicken vine, 160g of Polygonum cuspidatum, 200g of verbena, 200g of June snow, 200g of Malan grass, 200g of Mao berry, 170g of auspicious grass, 100g of Gonggong wood and 70g of cold water flower, and add it to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 900min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.30g.

[0028] After testing, the content of emodin in the finished product is 1.21mg / tablet.

Embodiment 3

[0030] Take 200g of chicken vine, 160g of Polygonum cuspidatum, 200g of verbena, 200g of June snow, 200g of Malan grass, 200g of Mao berry, 170g of auspicious grass, 100g of Gonggong wood and 70g of cold water flower, and add it to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 60°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 800min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.30g.

[0031] After testing, the content of emodin in the finished product is 0.95mg / tablet.

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and in particular relates to an application of a Yiganle tablet to preparation of drugs for inhibiting mast cell leukemia cell CHMas proliferation and a preparation method of the Yiganle tablet. The Yiganle tablet is prepared by using 200g of Chinese fevervine herb, 160g of giant knotweed rhizome, 200g of European verbena, 200g of snow of June herb, 200g of Chinese wedelia herb, 200g of rubus parvifolius, 170g of pink reineckea herb, 100g of Chinese mahonia stem and 70g of pilea notata as raw medicines and is prepared by adopting supercritical extraction, so that the content of emodin is greatly increased.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of Yiganle tablets in the preparation of drugs for inhibiting the proliferation of mast cell leukemia cells CHMas cells and the preparation method of Yiganle tablets. Background technique [0002] The standard number of Yiganle Granules is WS-10148 (ZD-0148)-2002, which is recorded in the Hepatobiliary Subvolume of the National Compilation of Chinese Patent Medicine Standards. It is made from 200g of Gallus vine, 160g of Polygonum cuspidatum, 200g of Verbena, 200g of June Snow, 200g of Malancao, 200g of Maoberry, 170g of Auspicious Grass, 100g of Gongluomu, and 70g of Lengshuihua. effect. For acute and chronic hepatitis B caused by liver and gallbladder damp heat. [0003] In the prior art, there is no report on the application of Yiganle tablets in the preparation of drugs for inhibiting the proliferation of human mast cell leu...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/20A61P35/00
CPCA61K36/74A61K9/2059A61K36/185A61K36/28A61K36/282A61K36/29A61K36/41A61K36/47A61K36/704A61K36/73A61K36/85A61K36/896A61K2236/37A61K2236/51A61K2300/00
Inventor 不公告发明人
Owner JINAN XINSHIDAI MEDICINE SCI & TECH
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