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Medicine composition for treating narcolepsy and preparing method thereof

A technology for narcolepsy and composition, which is applied in the field of traditional Chinese medicine, can solve problems such as many adverse reactions, obvious adverse reactions, and gastrointestinal dysfunction, and achieve the effects of simple preparation method, no toxic side effects, and convenient administration

Inactive Publication Date: 2016-07-06
李国玉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional central nervous system stimulants are rarely used because of obvious adverse reactions
New central stimulants such as modafinil have good safety, but there are adverse reactions such as headache, nausea, anxiety, tension, dry mouth, and diarrhea; sodium oxybate has many indications and a wide range of applications, but it also has dizziness, Ataxia, weight loss, depression, gastrointestinal dysfunction and other adverse reactions
Antidepressants are commonly used clinical anti-cataplexy drugs, which have certain effects on sleep paralysis and hypnagogic hallucinations, but have more adverse reactions than other drugs

Method used

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  • Medicine composition for treating narcolepsy and preparing method thereof
  • Medicine composition for treating narcolepsy and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Embodiment 1 capsule

[0038] Prescription: 10 parts of calamus, 15 parts of water fennel, 12 parts of loofah, 10 parts of sargassum, 15 parts of oxtail ginseng, 5 parts of cardamom, 10 parts of Atractylodes macrocephala, 8 parts of polygala, 10 parts of pokeweed flower, 5 parts of licorice .

[0039] Preparation method: (1) Take calamus calamus, water fennel, polygala and pokeweed flower according to the prescription, pulverize and mix them, add 75% ethanol with a concentration of 5 times the weight of the mixture and reflux for extraction twice, and the time of heating and reflux each time is After 0.5 to 2 hours, combine the extracts, filter, and concentrate under reduced pressure to form a thick paste;

[0040] (2) According to the prescription, weigh loofah, sargassum, oxtail ginseng, cardamom, Atractylodes macrocephala, licorice and calamus, water fennel, polygala, and pokeweed after ethanol extraction and filter residue, and add 6 times the weight of the mixture...

Embodiment 2

[0042] Embodiment 2 capsules

[0043] Prescription: 12 parts of Shichangpu, 15 parts of water fennel, 15 parts of loofah, 12 parts of soil arrow, 20 parts of oxtail ginseng, 5 parts of cardamom, 12 parts of Atractylodes macrocephala, 10 parts of polygala, 8 parts of pokeweed, 6 parts of licorice .

[0044] Preparation method: (1) Take calamus calamus, water fennel, polygala, pokeweed flower according to the prescription, pulverize and mix, add 75% ethanol with a concentration of 6 times the weight of the mixture and reflux for extraction twice, and the time of heating and reflux each time is After 0.5 to 2 hours, combine the extracts, filter, and concentrate under reduced pressure to form a thick paste;

[0045] (2) According to the prescription, weigh loofah, sargassum, oxtail ginseng, cardamom, Atractylodes macrocephala, licorice and calamus, water fennel, polygala, and pokeweed after ethanol extraction and filter residue, and add 5 times the weight of the mixture Decoctin...

Embodiment 3

[0047] Embodiment 3 capsules

[0048] Prescription: 8 parts of Shichangpu, 15 parts of water fennel, 15 parts of loofah, 8 parts of soil arrow, 15 parts of oxtail ginseng, 4 parts of cardamom, 8 parts of Atractylodes macrocephala, 8 parts of polygala, 8 parts of pokeweed, 5 parts of licorice .

[0049] Preparation method: (1) take calamus calamus, water fennel, polygala and pokeweed flower according to the prescription, grind and mix them, add 75% ethanol with a concentration of 4 times the weight of the mixture and reflux for extraction twice, and the time of heating and reflux each time is After 0.5 to 2 hours, combine the extracts, filter, and concentrate under reduced pressure to form a thick paste;

[0050] (2) According to the prescription, weigh loofah, sargassum, oxtail ginseng, cardamom, Atractylodes macrocephala, licorice and calamus, water fennel, polygala, and pokeweed after ethanol extraction and filter residue, and add 8 times the weight of the mixture Decoctin...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and relates to a medicine composition for treating narcolepsy and a preparing method thereof.The medicine composition is prepared from rhizoma acori graminei, all grass of winkled marshweed, loofah sponges, roots of longflower stringbush, airpotato yam rhizomes, katsumadai seeds, white atractylodes rhizomes, polygala roots, phytolacca flowers and liquorice in an elaborated mode.All medicinal materials reinforce each other and interact with each other, and the medicine composition has the effects of dissipating phlegm for resuscitation, tonifying the spleen, reinforcing the stomach, invigorating the spleen, eliminating dampness, removing dampness and dredging collaterals; if phlegm is cleared, the brain orifice is clear; if the spleen is healthy, qi-blood metaplasia is active, dampness and phlegm can not be generated, and nutrients are abundant; the traditional Chinese medicine discriminates that narcolepsy belongs to the syndrome of heart spirit confused by phlegm, medicine is dialectically used, both symptoms and root causes are treated, and the effect is remarkable.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical composition for treating narcolepsy and a preparation method thereof. Background technique [0002] Narcolepsy is a sleep disorder characterized by diurnal sleepiness, cataplexy, hallucinations, and sleep paralysis. According to whether it is accompanied by cataplexy, it is divided into narcolepsy with cataplexy and narcolepsy without cataplexy. The etiology of narcolepsy is still not very clear, and it is generally believed to be related to heredity and infection. The population prevalence rate is 0.03-0.16%, and it is on the rise, seriously affecting the quality of life of patients, and even causing accidents and endangering their lives. [0003] At present, Western medicine treatment is mainly suitable for patients with severe symptoms and frequent attacks. Traditional central nervous system stimulants are rarely used because of obvious adverse rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61P25/00
CPCA61K36/888A61K9/2004A61K9/4841A61K36/185A61K36/27A61K36/284A61K36/42A61K36/484A61K36/69A61K36/808A61K36/83A61K36/9062A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 李国玉
Owner 李国玉