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A preparation method of superparamagnetic nanoparticles based on low temperature plasma
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A magnetic nanoparticle, low temperature plasma technology, applied in the field of nanomaterials, can solve problems such as hindering the application of magnetic nanoparticles, poor water solubility and physiological stability of magnetic nanoparticles, and poor imaging effect.
Active Publication Date: 2018-02-13
PEKING UNIV
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Co-precipitation method is the simplest and most commonly used method for preparing magnetic nanoparticles, that is, a certain amount of high polymer, ferric salt and ferrous salt is dissolved in water, and a certain amount of ammonia water is added dropwise under stirring. Under the reaction for a period of time, superparamagnetic iron oxide nanoparticles with a certain particle size can be obtained, but the magnetic nanoparticles prepared by this method have a large particle size, low crystallinity, and low saturation magnetization, so the imaging effect in nuclear magnetic resonance imaging is limited. Difference
Synthesis of superparamagnetic nanoparticles by high-temperature pyrolysis can obtain magnetic nanoparticles with uniform particle size, but this method needs to be carried out at high temperature, the reaction process is very cumbersome, and the prepared magnetic nanoparticles have poor water solubility and physiological stability. Seriously hampers the application of this magnetic nanoparticle
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Embodiment 1
[0022] Embodiment 1: Preparation of ferroferromagnetic nanoparticles
[0023] (1) preparation concentration is the ferric chloride solution of 0.1mol / L, the ferrous chloride solution of 0.1mol / L, mixes by volume 1:2, obtains 100mL solution, drips ammonia solution and makes pH reach 5;
[0024] (2) Add 5g PEG (MW2000) to the solution obtained in step (1), and stir to dissolve it completely;
[0025] (3) The low-temperature plasma generating device is fed with an argon gas source with a gas flow rate of 200 sccm, driven by electricity, with a voltage of 1000V and a current of 15mA to generate low-temperature plasma;
[0026] (4) The mixed solution obtained in step (2) is treated with low-temperature plasma for 20 minutes to prepare a superparamagnetic ferroferric oxide nanoparticle solution;
[0027] (5) The magnetic nanoparticles are collected with a magnet, washed with deionized water, and dried in vacuum to store them for a long time.
Embodiment 2
[0028] Example 2: Detection of properties of ferroferromagnetic nanoparticles
[0029] 1) Using X-ray diffraction analysis (XRD), the diffractometer is equipped with Cu Ka (k=0.15406nm), scanning within 20-90°, and the voltage is set at 40kV. Depend on figure 1 It can be concluded that the X-ray diffraction angles are 2θ=18.299°, 30.100°, 35.454°, 43.088°, 53.455°, 56.983°, 62.574°, 74.026°, 89.685°, respectively, and the electron diffraction peaks [111], [220 ], [311], [400], [422], [511], [440], [533], [731] corresponding to the positions, it can be confirmed that the prepared nanoparticle powder is trioxide tetraoxide with magnetite structure iron.
[0030] 2) The Tecnai T20 transmission electron microscope (TEM) was used for observation, and the diluted magnetic particle solution was dropped on a copper support grid, and after drying at room temperature, the sample was directly used for TEM observation with an accelerating voltage of 200kV. For specific TEM images, see ...
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Abstract
The invention discloses a low-temperature plasma based preparation method for superparamagnetism nanoparticles. The preparation method comprises the following steps of firstly, mixing a trivalent ferric salt solution and a divalent ferrous salt solution, and adding an alkaline solution to adjust pH to be 5-6; secondly, adding a polymer and dissolving the polymer; and finally, processing the solution with low-temperature plasma to prepare the magnetic nanoparticles. In the nanopartciles prepared according to the method, the surfaces of Fe3O4 nanoparticle cores are coated with polymer molecules, the nanopartciles are uniform in grain size, have favorable dispersibility and superparamagnetism, and can be used for fields such as magnetic resonance imaging, cell marking, protein separation and tumor thermotherapy; and moreover, the preparation method adopting the technology has the advantages of simplicity, fast synthesis speed and low cost.
Description
technical field [0001] The invention belongs to the field of nanometer materials, and relates to a preparation method of superparamagnetic iron ferric oxide nanoparticles. Background technique [0002] In recent years, magnetic nanomaterials have attracted extensive attention due to their good magnetic properties and biological safety. In the field of biomedicine, magnetic nanoparticles with a particle size below 20nm have superparamagnetism, and have obvious advantages in the fields of cell labeling, tumor hyperthermia, nucleic acid extraction, and nuclear magnetic resonance imaging. [0003] There are two main methods for the synthesis of magnetic nanoparticles: physical methods and chemical methods. Physical methods include vacuum condensation method, physical crushing method, mechanical ball milling method, etc.; chemical methods mainly include coprecipitation method, pyrolysis method, microemulsion method and hydrothermal synthesis method, etc. Compared with physical ...
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