Potassium aspartate fat emulsion injection and preparation method
A technology of potassium aspartate and injection, which is applied in the fields of emulsion delivery, non-active ingredients of oil/fat/wax, and pharmaceutical formulations, and can solve problems such as pain and elevation at the puncture site
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Embodiment 1
[0062] Under the protection of nitrogen, weigh 120 g of soybean oil for injection, heat it to 70°C, add 13 g of egg yolk lecithin for injection and 0.8 g of potassium aspartate, stir at high speed until uniform, and make an oil phase. In addition, add 23 g of glycerin for injection, add an appropriate amount of water for injection, mix well, heat to 60°C, filter, mix with oil phase under high-speed stirring to make colostrum, then adjust the pH value to 9.5 with 10% sodium hydroxide solution, add water for injection to 1000ml, the colostrum is repeatedly emulsified by a two-step high-pressure homogenizer until the milk particle inspection is qualified (more than 97% of the particles are less than 1 u), and then filtered through a microporous membrane, filled in a 250-500ml glass bottle, and passed through Nitrogen, stoppering and capping were sterilized in a rotary steam sterilizer at 115°C for 30 minutes. Serve as Potassium Aspartate Fat Emulsion Injection after passing the i...
Embodiment 2
[0064] Under the protection of nitrogen, weigh 200 g of soybean oil for injection, heat it to 60°C, add 1.5 g of elemene, stir at high speed until uniform, and make an oil phase. In addition, add 22 g of glycerin for injection, add an appropriate amount of water for injection and mix well, then add 8 g of soybean lecithin for injection under high-speed stirring, mix well, heat to 70 ° C, mix with oil phase under high-speed stirring to make colostrum, and use 10 % sodium hydroxide solution to adjust the pH value to 8.5, add water for injection to the full volume of 1000ml, and repeatedly emulsify the colostrum through a two-step high-pressure homogenizer until the milk particles pass the inspection (more than 97% of the particles are less than 1 u), and then micro Porous filter membrane filter filling in 250 ~ 500ml glass bottles, nitrogen, stopper, capping in a rotary steam sterilizer 115 ℃ 30 minutes to sterilize. Serve as Potassium Aspartate Fat Emulsion Injection after pass...
Embodiment 3
[0066] Under the protection of nitrogen, weigh 150 g of soybean oil for injection, heat it to 80 °C, add 14 g of egg yolk lecithin for injection and 1.2 g of potassium aspartate, stir at high speed until uniform, and make an oil phase. In addition, add 24 g of glycerin for injection, add an appropriate amount of water for injection, mix well, heat to 50°C, filter, mix with oil phase under high-speed stirring to make colostrum, and then adjust the pH value to 8.5 with 10% sodium hydroxide solution, Add water for injection to 1000ml, and repeatedly emulsify the colostrum through a two-step high-pressure homogenizer until the milk particles pass the inspection (particles below 1 u, then filter through a microporous membrane and fill in a 250-500ml glass bottle, pass nitrogen, and stopper 1. Roll the cap and sterilize it in a rotary steam sterilizer at 115° C. for 30 minutes. After passing the inspection, it becomes potassium aspartate fat emulsion.
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