Potassium aspartate fat emulsion injection and preparation method thereof
A technology of potassium aspartate and aspartic acid, applied in emulsion delivery, non-active ingredients of oil/fat/wax, pharmaceutical formulations, etc., can solve problems such as pain and elevation at the puncture site
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Embodiment 1
[0063] Under the protection of nitrogen, weigh 120 g of soybean oil for injection, heat to 70°C, add 13 g of egg yolk lecithin for injection and 0.8 g of potassium aspartate, stir at high speed until uniform, and prepare an oil phase. In addition, add 23g of glycerin for injection, add appropriate amount of water for injection, mix well, heat to 60°C, filter, mix with oil phase under high-speed stirring to make colostrum, then use 10% sodium hydroxide solution to adjust the pH value to 9.5, add water for injection to 1000ml of colostrum is repeatedly emulsified by a two-step high-pressure homogenizer until the milk particles pass the inspection (more than 97% of the particles are less than 1u), and then filtered through a microporous membrane, filled in a 250-500ml glass bottle, nitrogen, Stoppering and capping were performed in a rotary steam sterilizer at 115°C for 30 minutes to sterilize. Serve as Potassium Aspartate Fat Emulsion Injection after passing the inspection.
Embodiment 2
[0065] Under the protection of nitrogen, weigh 200 g of soybean oil for injection, heat to 60° C., add 1.5 g of elemene, stir at high speed until uniform, and prepare an oil phase. In addition, add 22g glycerin for injection, add an appropriate amount of water for injection and mix well, then add 8g soybean lecithin for injection under high-speed stirring, mix well, heat to 70°C, mix with oil phase under high-speed stirring to make colostrum, and add 10% hydrogen Sodium oxide solution to adjust the pH value to 8.5, add water for injection to the full volume of 1000ml, and repeatedly emulsify the colostrum through a two-step high-pressure homogenizer until the milk particles pass the inspection (more than 97% of the particles are less than 1u), and then pass through a microporous membrane Filtrate and fill in 250-500ml glass bottles, pass nitrogen, stopper and cover, and sterilize in a rotary steam sterilizer at 115°C for 30 minutes. Serve as Potassium Aspartate Fat Emulsion In...
Embodiment 3
[0067] Under nitrogen protection, weigh 150 g of soybean oil for injection, heat it to 80°C, add 14 g of egg yolk lecithin for injection and 1.2 g of potassium aspartate, stir at high speed until uniform, and prepare an oil phase. In addition, add 24g of glycerin for injection, add appropriate amount of water for injection, mix well, heat to 50°C, filter, mix with oil phase under high-speed stirring to make colostrum, then adjust pH value to 8.5 with 10% sodium hydroxide solution, add Water for injection to 1000ml, the colostrum is repeatedly emulsified by a two-step high-pressure homogenizer until the milk particle inspection is qualified (particles below 1u, then filtered through a microporous membrane and filled in a 250-500ml glass bottle, nitrogen, stoppered, rolled Cover and sterilize in a rotary steam sterilizer at 115°C for 30 minutes. If it passes the inspection, it becomes potassium aspartate fat emulsion.
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