Medicine composition for treating after-radiotherapy skin injuries of cervical cancer patient and application of medicine composition

A technology of skin damage and composition, applied in the field of medicine, can solve problems such as interruption of treatment, unhealed skin ulcers in the irradiated area, and no disclosure of biological activity

Inactive Publication Date: 2016-07-20
董记刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the increase of the cumulative dose, severe wet reaction and ulceration may occur if the reaction of the above-mentioned parts is aggravated. If the prevention and treatment are not timely in the early stage, once the ulcer and infection are formed, the whole process of radiotherapy may be affected, and the treatment may even be interrupted. There will be prolonged skin ulcers in the irradiated area, which will cause great pain to the patient
[0003] CN105218532A discloses a benzotriazole small molecule compound or a pharmaceutically acceptable acid addition salt thereof, and also discloses the benzotriazole small molecule compound or a pharmaceutically acceptable acid addition salt thereof It is used in the preparation of drugs for the treatment of various malignant tumor growth, metastasis and recurrence caused by mutations in the RAS gene. However, it does not disclose the biological effects of this type of compound on the treatment of skin lesions after radiotherapy in patients with cervical cancer or the treatment of diabetic complications. active

Method used

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  • Medicine composition for treating after-radiotherapy skin injuries of cervical cancer patient and application of medicine composition
  • Medicine composition for treating after-radiotherapy skin injuries of cervical cancer patient and application of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Preparation of 5-(N-2-phenylethylamino)-2-(4-methoxyphenyl)-2H-benzotriazole

[0014] (1) Dissolve p-methoxyaniline (2.48g, 20.14mmol) in 48ml of aqueous hydrochloric acid (4M), add sodium nitrite (1.67g, 24.17mmol) under ice bath conditions, and react for half an hour. Ammonium sulfamate (3.16 g) was slowly added to the system at 0°C and stirring was continued for half an hour. The pH of the solution was adjusted to 5-6 with sodium acetate, and o-phenylenediamine hydrochloride (3.33 g, 18.42 mmol) was added to the reaction system under ice-bath conditions, and stirred overnight. After the completion of the reaction as detected by TLC, adjust the pH to greater than 14 with sodium hydroxide solution, extract with ethyl acetate and water, combine the organic phases, and distill under reduced pressure to obtain a dry crude azo compound. The azo compound was dissolved with 40ml of pyridine, and 10g of anhydrous copper sulfate was added to 60ml of concentrated am...

Embodiment 2

[0017] Example 2: Preparation of 5-(N-2-phenylethylamino)-2-(4-methoxyphenyl)-2H-benzotriazole (hereinafter referred to as RS042) liquid

[0018]

[0019] Preparation method: under normal temperature and pressure, weigh 10g of propylene glycol, dissolve it in an appropriate amount of distilled water, then add 1.5g of RS042 and 0.01g of sodium benzoate according to the ratio of each component in the prescription, stir to dissolve, and finally add distilled water to 100ml, stir well, mix well, adjust the pH to 7.0 at the same time, fill in cans, seal, and inspect to get the finished product.

Embodiment 3

[0020] Example 3: Study on the curative effect of RS042 medicinal solution on patients with skin damage after radiotherapy for cervical cancer

[0021] There were 52 cases of cervical cancer, including 23 cases of squamous cell carcinoma and 29 cases of adenocarcinoma. They were randomly divided into an observation group of 26 cases and a control group of 26 cases. The observation group was 25 to 59 years old, with an average (44.2±9.6) years old, and the control group was 24 to 60 years old, with an average (45.7±8.5) years old. There was no significant difference in age comparison and pathological classification between the two groups, which were comparable. All patients were treated with linear accelerator X-ray external irradiation, point B DT40Gy~50Gy / 20~25 times / 4~5 weeks; intracavitary afterloading treatment, using 198Ir afterloading intracavitary radiotherapy, A point DT4 dose 30~36Gy / 5 ~6 times. Nursing guidance for each group of cases: keep the perineum clean and d...

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PUM

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Abstract

The invention discloses a medicine composition for treating the after-radiotherapy skin injuries of a cervical cancer patient and application of the medicine composition.The medicine composition is prepared from active components and auxiliaries.The active components include 5-(N-2-phenylethylamino)-2-(4-methoxyphenyl)-2H-benzotriazole.The phagocytosis and chemotaxis functions of neutral granular cells can be improved, the treatment effect on treating the after-radiotherapy skin injuries of the cervical cancer patient through external application is remarkable, and the composition is easy to operate, convenient to use, free of adverse events, safe and reliable.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating skin damage of patients with cervical cancer after radiotherapy and an application thereof. Background technique [0002] Cervical cancer is a malignant tumor that originates in the cervix of the cervix, ranking first among malignant tumors of the female reproductive organs. Surgery is the main method for the treatment of cervical cancer, but it can only be used in the early stage (stage 0 or stage Ia). One of the important treatments for cervical cancer. Radiation therapy for cervical cancer is generally irradiated after 1 / 3 of the radical dose, and skin erythema, exudate and damage can appear in the irradiated area. Friction between urine and underwear and underwear can easily cause infection. With the increase of the cumulative dose, severe wet reaction and ulceration may occur if the reaction of the above-mentioned part...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4192A61P17/02
CPCA61K31/4192
Inventor 董记刚齐迎李茂江
Owner 董记刚
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