Composite biological material for eliminating bacterial biofilm

A technology of composite biomaterials and biofilms, applied in the field of new composite biomaterials, can solve problems such as amputation, operation failure, multiple operations, etc., and achieve the effect of enhancing the inhibition ability

Inactive Publication Date: 2016-07-20
NINGXIA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, implant infection accounts for about 45% of nosocomial infections, mainly because biofilm can be formed on the surface of medical implants. The infection will always exist until the implant is removed, and the remov

Method used

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  • Composite biological material for eliminating bacterial biofilm
  • Composite biological material for eliminating bacterial biofilm
  • Composite biological material for eliminating bacterial biofilm

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Embodiment Construction

[0036] The technical solutions of the present invention will be further described below through specific embodiments.

[0037]The present invention eliminates the composite biological material of bacterial biofilm, and ethylenediaminetetraacetic acid (EDTA), lactic acid, sodium dodecyl sulfate (SDS), nonanoic acid, and monoglyceride laurate (GML) are compounded to be able to effectively remove The biofilm removal matrix of the biofilm is combined with aloperine to form a composite biomaterial, which is applied to eliminate bacterial biofilm.

[0038] The experimental strains of the present invention are Staphylococcus aureus producing biofilm standard strain and Staphylococcus epidermidis producing biofilm standard strain, which are common Gram-positive bacteria that are easy to form biofilm in clinical practice.

[0039] The minimum inhibitory concentration (MIC) determination of 1.5 kinds of compounds to Staphylococcus aureus and Staphylococcus epidermidis

[0040] The fina...

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Abstract

The invention discloses a composite biological material for eliminating a bacterial biofilm.Ethylenediaminetetraacetic acid, lactic acid, lauryl sodium sulfate, n-nonanoic acid and glycerol monolaurate are compounded into a biofilm eliminating matrix capable of effectively eliminating the biofilm, the biofilm eliminating matrix and aloperine form the composite biological material, and the composite biological material is applied to eliminating the bacterial biofilm.The novel biofilm eliminating matrix capable of effectively eliminating the biofilm and aloperine form the composite biological material for eliminating the bacterial biofilm, the composite biological material is applied to eliminating the bacterial biofilm and has the advantages of being safe, free of resistance and environmentally friendly, through combined use, the inhibiting capacity of aloperine for the gram-positive bacterium biofilm can be enhanced, the defects of antibiotic therapy can be overcome, and the composite biological material is a novel biofilm eliminating biological material which is effective and free of resistance.

Description

Technical field: [0001] The invention belongs to the field of biotechnology and pharmacy, and in particular relates to a novel composite biological material used for eliminating bacterial biofilms. Background technique: [0002] Biofilm is a unique environment created by microorganisms for themselves. It was discovered in the mid-1970s. With the deepening of biofilm research, it was found that bacteria not only exist in a planktonic state in nature, but more often they are attached to organic matter. The surface of living or inanimate objects grows in the form of biofilm. Biofilms can be seen everywhere in life. There are biofilms on the surface of metal materials, medical implants, and teeth. The biofilm formed on the surface of teeth and medical implants is difficult to eliminate and seriously threatens human health. Therefore, it is effective in preventing and controlling bacteria. Biofilm and its related hazards have become a hot research topic at present. Biofilm elim...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L31/16A61K8/97A61K8/44A61K8/365A61K8/46A61K8/36A61K8/37A61Q11/00
CPCA61K8/361A61K8/365A61K8/375A61K8/44A61K8/463A61K8/97A61L27/54A61L31/16A61L2300/21A61L2300/214A61L2300/30A61L2300/404A61Q11/00
Inventor 周学章李雪王玉炯
Owner NINGXIA UNIVERSITY
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