Pharmaceutical composition of cefdinir and medical application thereof

A technology of cefdinir and a composition, which is applied in the field of pharmaceutical compositions of cefdinir, can solve problems such as no reports related to cerebral ischemia-reperfusion injury of cefdinir, and achieve outstanding substantive characteristics, remarkable progress, The effect of improving the protection effect
CN105820144AInactive Publication Date: 2016-08-03吴珺
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
吴珺
Publication Date
2016-08-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a pharmaceutical composition of cefdinir and its medical application. The pharmaceutical composition of cefdinir provided by the invention contains cefdinir and a novel natural product compound (I), cefdinir Compound (Ⅰ) can significantly improve the neurological function scores of rats with cerebral ischemia-reperfusion and significantly reduce the expression levels of inflammatory cytokines TNF-α, IL-1β and adhesion molecules VCAM-1 and ICAM-1. The combined effect is better than single use, and can be developed into a drug for protecting cerebral ischemia-reperfusion injury.
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Description

Technical field

[0001] The invention belongs to the field of biomedicine, and relates to a new use of cefdinir, in particular to a pharmaceutical composition of cefdinir and its medical use. Background technique

[0002] Cefdinir is used for Staphylococcus, Streptococcus, Pneumococcus, Peptostreptococcus, Propionibacterium, Neisseria gonorrhoeae, Moraxella catarrhalis, Escherichia coli, Klebsiella that are sensitive to cefdinir Bacteria, Proteus mirabilis, Providencia, Haemophilus influenzae and other strains cause infections.

[0003] There is a lot of evidence that ischemia alone is not enough to cause tissue damage, but it occurs when the blood supply is suddenly restored (ie, reperfusion) after a period of ischemia. In traumatic shock, surgery, organ transplantation, burns, frostbite and thrombosis and other blood circulation disorders, reperfusion injury after ischemia will occur. The damage of capillaries and parenchymal organs caused by ischemic tissue reperfusion is mainl...

Claims

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