Pharmaceutical composition of cefdinir and medical application thereof

A technology of cefdinir and a composition, which is applied in the field of pharmaceutical compositions of cefdinir, can solve problems such as no reports related to cerebral ischemia-reperfusion injury of cefdinir, and achieve outstanding substantive characteristics, remarkable progress, The effect of improving the protection effect

Inactive Publication Date: 2016-08-03
吴珺
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there has been no report on the correlation between cefdinir and its pharmaceutical composition and cerebral ischemia-reperfusion injury

Method used

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  • Pharmaceutical composition of cefdinir and medical application thereof
  • Pharmaceutical composition of cefdinir and medical application thereof
  • Pharmaceutical composition of cefdinir and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Compound (Ⅰ) isolation preparation and structure confirmation

[0022] Reagent sources: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane are analytically pure, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd., methanol, analytically pure, purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0023] Separation method: (a) Crush Audi tea (2kg), heat reflux with 85% ethanol for extraction (15L×3 times), combine the extracts, concentrate to no alcohol (3L), and then use petroleum ether (3L×3) Times), ethyl acetate (3L×3 times) and water-saturated n-butanol (3L×3 times) to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) The ethyl acetate extract is removed with D101 type macroporous resin. First eluted with 30% ethanol for 6 column volumes, and then eluted with 85% ethanol for 12 column volumes. Collect 85% eluate and reduce pressure. Concentrate to obtain 85% ethanol eluti...

Embodiment 2

[0026] Example 2: Pharmacological effects

[0027] 1. Materials and methods

[0028] 1.1 Animals

[0029] 60 adult healthy male Sprague-Dawley (SD) rats, SPF grade, weighing 280-300g, provided by Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd. During the experiment, the rat's rearing environment was stable, with room temperature (25±2)°C, relative humidity (55±5)%, and lighting control for 12h alternate day and night.

[0030] 1.2 Reagents and samples

[0031] Cefdinir was purchased from China Institute for Food and Drug Control. Compound (I) is self-made, and the preparation method is shown in Example 1. Edaravone injection (Sinopharm Group Guorui Pharmaceutical Co., Ltd.). Rabbit anti-mouse GFAP antibody, rabbit anti-mouse Iba1 antibody were purchased from Vector; rabbit anti-mouse TNF-α antibody, rabbit anti-mouse IL-1β, rabbit anti-mouse VCAM-1 antibody, rabbit anti-mouse ICAM-1 antibody were purchased from San- ta-Cruz; horseradish peroxidase-labeled goat anti-rab...

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PUM

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Abstract

The invention discloses a pharmaceutical composition of cefdinir and its medical application. The pharmaceutical composition of cefdinir provided by the invention contains cefdinir and a novel natural product compound (I), cefdinir Compound (Ⅰ) can significantly improve the neurological function scores of rats with cerebral ischemia-reperfusion and significantly reduce the expression levels of inflammatory cytokines TNF-α, IL-1β and adhesion molecules VCAM-1 and ICAM-1. The combined effect is better than single use, and can be developed into a drug for protecting cerebral ischemia-reperfusion injury.

Description

Technical field [0001] The invention belongs to the field of biomedicine, and relates to a new use of cefdinir, in particular to a pharmaceutical composition of cefdinir and its medical use. Background technique [0002] Cefdinir is used for Staphylococcus, Streptococcus, Pneumococcus, Peptostreptococcus, Propionibacterium, Neisseria gonorrhoeae, Moraxella catarrhalis, Escherichia coli, Klebsiella that are sensitive to cefdinir Bacteria, Proteus mirabilis, Providencia, Haemophilus influenzae and other strains cause infections. [0003] There is a lot of evidence that ischemia alone is not enough to cause tissue damage, but it occurs when the blood supply is suddenly restored (ie, reperfusion) after a period of ischemia. In traumatic shock, surgery, organ transplantation, burns, frostbite and thrombosis and other blood circulation disorders, reperfusion injury after ischemia will occur. The damage of capillaries and parenchymal organs caused by ischemic tissue reperfusion is mainl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/00A61K31/343A61K31/546A61P9/10
CPCC07D307/00A61K31/343A61K31/546
Inventor 吴珺
Owner 吴珺
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