Method and device for freeing samples and performing mass spectrometry analysis

Abstract

A method and device for dissociating samples and performing mass spectrometry analysis, the method includes a combustion step, a desorption / dissociation step, and an analysis step. The combustion step is to prepare a combustion unit capable of generating a combustion reaction, generate at least one reactive charged species through the combustion reaction, and cause a sample to be tested to generate thermal desorption due to the temperature of the combustion reaction, forming several sample particles . In the desorption / dissociation step, the thermally desorbed sample particles and the charged species produced by the combustion reaction undergo a gas-phase chemical reaction, and a dissociation phenomenon occurs to form several analyte ions. The analysis step is to introduce the analyte ions into a mass spectrometer for mass spectrometry analysis. The combustion unit can be used simply to generate a combustion reaction so that the sample to be tested can form analyte ions that can be analyzed by a mass spectrometer.

Description

technical field [0001] The invention relates to a method and device for freeing samples and performing mass spectrometry analysis, in particular to a method and device for freeing samples with combustion reaction products and performing mass spectrometry analysis. Background technique [0002] refer to figure 1 , is an existing device for freeing samples by corona discharge and performing mass spectrometry analysis, the device includes a spray unit 11 for spraying sample mist particles 21, a corona needle tip 12 arranged downstream of the spray unit 11, And a mass spectrometer 13 disposed downstream of the corona needle tip 12 and having a sample inlet 131 . The spray unit 11 includes a capillary 111 for transporting samples, a gas supply tube 112 surrounding the capillary 111 for providing high-pressure gas for atomizing the sample, and a heater 113 disposed outside the gas supply tube 112 . [0003] The main function of the spray unit 11 is to desorb the sample to be tes...

AI Technical Summary

Problems solved by technology

[0004] However, since a high voltage must be applied to the corona needle tip 12 to generate the corona discharge phenomenon, a considerable amount of energy will be consumed, and it is also necessary to cooperate with the spray unit 11 to desorb the sample to be tested in order to have a better ionization effect , so the use of corona discharge to ionize the sample has the disadvantage of complex experimental equipment, and it is impossible to perform mass spectrometry analysis quickly and easily.

In order to produce a better corona discharge effect and maintain the safety of the experiment under the condition of using high voltage, relatively sophisticated and expensive experimental equipment is also required, so the cost is high, and the experimental equipment is inconvenient to carry and move due to its large size Shortcomings

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