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Method for treating hypertriglyceridemia with a Wedelia chinensis extract

A technology for hypertriglyceridemia and lipidemia, which is applied in the field of treating hypertriglyceridemia with Wedelia extract, and can solve problems such as effective control of hypertriglyceride levels

Inactive Publication Date: 2016-08-10
WYNTEK CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Current pharmacological treatments for hypertriglyceridemia fail to effectively control hypertriglyceride levels without adverse adverse effects

Method used

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  • Method for treating hypertriglyceridemia with a Wedelia chinensis extract
  • Method for treating hypertriglyceridemia with a Wedelia chinensis extract
  • Method for treating hypertriglyceridemia with a Wedelia chinensis extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 : Preparation of an acidic aqueous extract of Wedelia (W.chinensis)

[0034] Whole Wedelia plants were dried and crushed into pieces with a size less than 0.2 cm. 250mL of food-grade acetic acid (99.8%) and 750mL of reverse osmosis water (RO H 2 O) Crushed Wedelia added to 100 g. The resulting mixture was boiled for 90 minutes and then cooled to room temperature. The boiled mixture was filtered to remove insoluble residue. The filtrate was concentrated on a rotary evaporator to a volume of ~35 mL. The concentrate was diluted with water to a volume of 1 L and evaporated again. These dilution and evaporation steps were repeated until the pH of the diluted material was above 4.0. The thus obtained concentrated acidic aqueous extract of Wedelia was mixed with an equal weight of microcrystalline cellulose. The mixture was stirred for 10 minutes and then lyophilized.

[0035] Analysis of the acidic aqueous extract of Wedelia was performed by ultra performan...

Embodiment 2

[0038] Example 2 : Preparation of ethanol extract of Wedelia

[0039] Ethanolic extracts of Wedelia were prepared essentially as described in Lin. UPLC analysis of the ethanol extract was performed as described in Example 1 above. Biological activity was also assessed as described above.

[0040] UPLC data ( Figure 1B ) and biological activity data ( Figure 2B ) shows that the ethanol extract has similar composition and activity to the acidic water extract of Wedelia.

Embodiment 3

[0041] Example 3 : Short-term treatment of hypertriglyceridemia with Wedelia extract

[0042] Five subjects were orally administered 6 g of the acidic aqueous extract of Wedelia described in Example 1 above once a day for 3 months. Serum triglyceride levels of these subjects were measured at the beginning of treatment and at 1-month intervals. The results are shown in Table 1 below.

[0043] Table 1. Lowering of Serum Triglycerides with Wedelia Extract

[0044] subjects

day 0

day 30

Day 60

Day 90

1

159 a

129

124

92

2

175

171

132

66

3

149

222

188

135

4

266

159

210

167

5

172

233

182

152

[0045] a A numerical value representing serum triglyceride levels expressed in mg / dL

[0046] The results indicated that treatment with the acidic aqueous extract of Wedelia successfully reduced serum triglyceride levels in all subjects.

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PUM

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Abstract

A method for treating hypertriglyceridemia with a composition containing wedelolactone, luteolin, and apigenin. Also provided is a method for reducing the risk of developing hypertriglyceridemia by administering the composition to a subject at risk thereof. The composition can be an extract of Wedelia chinensis.

Description

technical field [0001] The present application relates to the treatment of hypertriglyceridemia (hypertriglyceridemia, hypertriglyceridemia) and reducing the risk of developing this condition. Background technique [0002] Triglyceride (triglyceride, triglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the major lipid constituents of dietary fats and fat depots of animals. Triglycerides are transferred between tissues (eg, between adipose tissue and liver tissue) via blood by lipoprotein particles. The highest triglyceride concentrations are found in chylomicrons and very low-density lipoprotein particles. [0003] The American Heart Association classifies individuals according to their fasting serum triglyceride levels as follows: <150 mg / dL, normal; 150 to 199 mg / dL, borderline high; 200 to 499 mg / dL, high; and ≥ 500mg / dL, very high. Elevated triglyceride levels (known as hypertriglyceridemia) lead to the development of atheroscle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61K31/352A61P3/06
CPCA61K31/352A61K31/37A61K2300/00A61K36/28A61P13/12A61P3/04A61P3/06A61P39/00A61P43/00A61P5/14A61P9/10A61P3/10A61K31/366A61K31/353
Inventor 涂仓荣许文迈范清亮
Owner WYNTEK CORP
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