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Preparation method of polyurethane hydrogel with amphoteric pH-response groups

A technology of responsive groups and hydrogels, applied in the field of polyurethane hydrogel preparation, can solve problems such as defects in intelligent response characteristics, achieve the effect of improving mechanical properties and expanding the scope of application

Active Publication Date: 2016-08-31
HUNAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually, temperature- and pH-responsive polyurethane hydrogels contain only one pH-sensitive functional group and can only respond intelligently to a single pH value.
When the pH value of the external environment changes continuously, the intelligent response properties exhibited by this type of hydrogel still have some defects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Polyethylene glycol (number-average relative molecular mass is 4000) 40 kg, hexamethylene diisocyanate 3.4 kg, dimethyl formamide 60 kg, dibutyl tin dilaurate 12.0×10 -3 Kilogram, put it into a 300L reaction kettle with a stirrer, thermometer and reflux condenser, and react at a temperature of 80°C for 3 hours. Then, 1.4 kilograms of 2,2-dimethylolpropionic acid, 1.7 kilograms of hexamethylene diisocyanate, and 15 kilograms of dimethylformamide were added, the temperature was controlled at 80°C, and the reaction was carried out for 3 hours to obtain the prepolymer I, which was used for later use. Polyethylene glycol (number-average relative molecular mass is 4000) 40 kg, hexamethylene diisocyanate 3.4 kg, dimethyl formamide 60 kg, dibutyl tin dilaurate 12.0×10 -3 Kilogram, put it into another 300L reaction kettle with stirrer, thermometer and reflux condenser, and react at 80°C for 3 hours. Then, 1.2 kg of N-methyldiethanolamine, 1.7 kg of hexamethylene diisocyanate, and ...

Embodiment 2

[0033] Polyethylene glycol (number-average relative molecular mass is 4000) 40 kg, hexamethylene diisocyanate 3.4 kg, dimethylacetamide 60 kg, dibutyltin dilaurate 12.0×10 -3 Kilogram, put it into a 300L reactor with a stirrer, thermometer and reflux condenser, and react at a temperature of 82°C for 3 hours. Then, 2.8 kg of 2,2-dimethylolpropionic acid, 5.1 kg of hexamethylene diisocyanate, and 20 kg of dimethylacetamide were added, the temperature was controlled at 82° C., and the reaction was carried out for 3 hours to obtain the prepolymer I for use. Polyethylene glycol (number-average relative molecular mass is 4000) 40 kg, hexamethylene diisocyanate 3.4 kg, dimethylacetamide 60 kg, dibutyltin dilaurate 12.0×10 -3 Kg, put it into another 300L reaction kettle with a stirrer, thermometer and reflux condenser, and react at 82°C for 3 hours. Then, 2.4 kg of N-methyldiethanolamine, 5.1 kg of hexamethylene diisocyanate, and 20 kg of dimethylacetamide were added, the temperature wa...

Embodiment 3

[0036] Polyethylene glycol (number-average relative molecular mass is 4000) 40 kg, isophorone diisocyanate 4.6 kg, dimethyl sulfoxide 60 kg, dibutyl tin dilaurate 12.0×10 -3 Kilogram, put it into a 300L reactor with a stirrer, thermometer and reflux condenser, and react at 85°C for 3 hours. Then, 2.8 kg of 2,2-dimethylolpropionic acid, 6.9 kg of isophorone diisocyanate, and 20 kg of dimethyl sulfoxide were added, the temperature was controlled at 85° C., and the reaction was carried out for 3 hours to obtain prepolymer I for use. Polyethylene glycol (number-average relative molecular mass is 4000) 40 kg, isophorone diisocyanate 4.6 kg, dimethyl sulfoxide 60 kg, dibutyl tin dilaurate 12.0×10 -3 Kilogram, put it into another 300L reaction kettle with stirrer, thermometer and reflux condenser, and react at 85°C for 3 hours. Then, 2.4 kg of N-methyldiethanolamine, 6.9 kg of isophorone diisocyanate, and 20 kg of dimethyl sulfoxide were added, the temperature was controlled at 85° C.,...

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Abstract

The invention discloses a preparation method of polyurethane hydrogel with amphoteric pH-response groups. The preparation method mainly comprises the following steps: (1) reacting polyethylene glycol, aliphatic isocyanate, a catalyst and a solvent in a reaction kettle, so as to obtain a polyurethane prepolymer; and (2) adding aliphatic isocyanate, a chain extender with acid groups and a solvent into the reaction kettle to have a reaction further, so as to obtain a prepolymer I; repeating the reactions in the steps (1) and (2) in another reaction kettle, so as to obtain a prepolymer II, wherein the chain extender with the acid groups is replaced with a chain extender with the alkali groups; pouring the prepolymer I and the prepolymer II into the same reaction kettle, and adding a cross-linking agent with containing hydroxyl and a solvent to have a reaction further, so as to obtain a polyurethane solution; pouring the polyurethane solution into a mold, drying, soaking in an alkali solution, and adding an aziridine cross-linking agent to react, so as to obtain polyurethane hydrogel; and soaking the polyurethane hydrogel in deionized water, and carrying out freeze drying after soaking, so as to obtain the polyurethane hydrogel with the amphoteric pH-response groups.

Description

Technical field [0001] The invention belongs to the technical field of production of polyurethane hydrogels, and specifically relates to a method for preparing a polyurethane hydrogel with acidic and alkaline response groups and capable of dual sensitivity to environmental temperature and pH. Background technique [0002] Polyurethane hydrogel is a high molecular polymer whose molecular chain is mainly composed of polyurethane and has a three-dimensional network structure that can swell in water but is not dissolved in water. Polyurethane smart hydrogel is a polyurethane-based polymer that can intelligently sense the external environment and respond intelligently to changes in the external environment. Polyurethane smart hydrogel has excellent mechanical properties and biocompatibility, so it has shown broad application prospects in material separation, drug slow release, biomimetic organs, molecular imprinting, etc. [0003] Polyurethane smart hydrogels can be divided into temper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/66C08G18/48C08G18/32C08G18/34C08G18/38C08G18/10
CPCC08G18/10C08G18/3844C08G18/4833C08G18/6659C08G2210/00C08G18/348C08G18/3275
Inventor 周虎余斌熊一帜唐友新欧宝立刘玄漆志凌
Owner HUNAN UNIV OF SCI & TECH