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A kind of polyn-isopropylacrylamide hydrogel and its preparation method and application

A technology of isopropylacrylamide and methacryloyl chloride, applied in the field of smart hydrogels, can solve the problems of poor mechanical properties of PNIPAAm hydrogels

Active Publication Date: 2018-06-29
LINYI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the shortcomings of poor mechanical properties of PNIPAAm hydrogels in the prior art, the primary purpose of the present invention is to provide a poly-N-isopropylacrylamide hydrogel with excellent mechanical properties, specifically, a poly(N-isopropylacrylamide) hydrogel with Poly(N-isopropylacrylamide) hydrogel with methacrylic acid-terminated dipentaerythritol polycaprolactate (DPCLMAC) as six-arm crosslinker

Method used

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  • A kind of polyn-isopropylacrylamide hydrogel and its preparation method and application
  • A kind of polyn-isopropylacrylamide hydrogel and its preparation method and application
  • A kind of polyn-isopropylacrylamide hydrogel and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0034] (1) Preparation of dipentaerythritol polycaprolactate (DPCL)

[0035] Add 0.254g of dipentaerythritol (DPE, 1mmol) and 0.685g of 6-caprolactone (ε-CL, 60mmol) into a round bottom flask, protect it with nitrogen, melt and mix it evenly at 120°C, and then add 0.1wt% Stannous octoate was used as a catalyst, and the reaction was carried out at 120°C for 6 hours under the protection of nitrogen. After the reaction is completed, cool to room temperature, dissolve with dichloromethane, then add dropwise to ice-cold n-hexane / methanol to precipitate, filter, dry, and vacuum dry;

[0036] (2) Preparation of methacrylic acid-terminated dipentaerythritol polycaprolactate (DPCLMAC)

[0037] Dissolve 0.65g (1 mmol) of DPCL in 40g of dichloromethane, add 0.55g (54 mmol) of triethylamine, stir to dissolve completely, add dropwise 0.38g of methacryloyl chloride (MAC, 36 mmol ) and 20g of dichloromethane, the dropwise addition time is controlled at 2-3h, after the dropwise addition is ...

Embodiment 2

[0041] (1) Preparation of dipentaerythritol polycaprolactate (DPCL)

[0042] Add 0.254g of dipentaerythritol (DPE, 1mmol) and 0.685g of 6-caprolactone (ε-CL, 60mmol) into a round bottom flask, protect it with nitrogen, melt and mix it evenly at 120°C, and then add 0.1wt% Stannous octoate was used as a catalyst, and the reaction was carried out at 120°C for 6 hours under the protection of nitrogen. After the reaction is completed, cool to room temperature, dissolve with dichloromethane, then add dropwise to ice-cold n-hexane / methanol to precipitate, filter, dry, and vacuum dry;

[0043] (2) Preparation of methacrylic acid-terminated dipentaerythritol polycaprolactate (DPCLMAC)

[0044] Dissolve 0.65g (1 mmol) of DPCL in 40g of dichloromethane, add 0.55g (54 mmol) of triethylamine, stir to dissolve completely, add dropwise 0.38g of methacryloyl chloride (MAC, 36 mmol ) and 20g of dichloromethane, the dropwise addition time is controlled at 2-3h, after the dropwise addition is ...

Embodiment 3

[0048] (1) Preparation of dipentaerythritol polycaprolactate (DPCL)

[0049] Add 0.254g of dipentaerythritol (DPE, 1mmol) and 0.685g of 6-caprolactone (ε-CL, 60mmol) into a round bottom flask, protect it with nitrogen, melt and mix it evenly at 120°C, and then add 0.1wt% Stannous octoate was used as a catalyst, and the reaction was carried out at 120°C for 6 hours under the protection of nitrogen. After the reaction is completed, cool to room temperature, dissolve with dichloromethane, then add dropwise to ice-cold n-hexane / methanol to precipitate, filter, dry, and vacuum dry;

[0050] (2) Preparation of methacrylic acid-terminated dipentaerythritol polycaprolactate (DPCLMAC)

[0051] Dissolve 0.65g (1 mmol) of DPCL in 40g of dichloromethane, add 0.55g (54 mmol) of triethylamine, stir to dissolve completely, add dropwise 0.38g of methacryloyl chloride (MAC, 36 mmol ) and 20g of dichloromethane, the dropwise addition time is controlled at 2-3h, after the dropwise addition is ...

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Abstract

The present invention relates to the technical field of intelligent hydrogel, and in particular to a novel poly N-isopropylacrylamide hydrogel. Dipentaerythritol and 6-caprolactone react to obtain dipentaerythritol caprolactone; methacryloyl chloride and dipentaerythritol caprolactone react to obtain methacrylic acid terminated dipentaerythritol caprolactone; N-isopropylacrylamide and methacrylic acid terminated dipentaerythritol caprolactone react to obtain a novel poly N-isopropylacrylamide hydrogel. The method uses NIPAAm as a polymerization main body to ensure the temperature intelligent response performance of the hydrogel, which is in favor of simulation of the actual biological environment; the introduction of a multi-arm crosslinking agent containing a polycaprolactone functional segment can realize regulation of the response temperature of hydrogel; and the multi-arm crosslinking agent containing polycaprolactone functional segment with good biocompatibility can significantly improve the mechanical properties of the hydrogel, so as to better meet the needs of practical application.

Description

technical field [0001] The invention relates to the technical field of intelligent hydrogel, in particular to a poly-N-isopropylacrylamide hydrogel, and also to its preparation method and application. Background technique [0002] Hydrogel is a polymer with a three-dimensional cross-linked network structure that can swell and absorb a large amount of water without dissolving in aqueous solution. Generally speaking, hydrogels can be divided into traditional hydrogels and smart hydrogels. Traditional hydrogels are a class of polymers that cannot respond to external stimuli, also known as non-stimuli-responsive hydrogels. Smart hydrogels can also be called stimuli-responsive hydrogels, or sensitive hydrogels, which are a type of hydrogels that can respond to external stimuli. External stimuli mainly include: temperature, pH, electric field, magnetic field, light or pressure, etc. Therefore, according to different stimulation signals, it can be divided into temperature-sensit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F283/01C08F220/54C08G63/91C08G63/08C08J3/075A61K47/32
CPCA61K47/32C08F220/54C08F283/01C08G63/08C08G63/91C08J3/075C08J2351/08
Inventor 李因文孙婉张江浩刘亚琪
Owner LINYI UNIVERSITY
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