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Method and apparatus for controlling ion reaction based on linear ion well

A linear ion trap and ion reaction technology, applied in the field of mass spectrometry, can solve the problems of reduced detection efficiency and increased sample consumption, and achieve the effect of improving accuracy

Inactive Publication Date: 2016-09-07
NAT INST OF METROLOGY CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In the mass spectrometry detection of gas-phase ion reactions, positive and negative ions are stored in the reactor respectively for reaction, and the reactor usually has a relatively complicated mechanical structure; after the reaction, different operating parameters are used to perform positive ion mode detection or negative ion mode detection respectively. Continue to perform follow-up detection such as secondary mass spectrometry under the condition of excluding a polar ion, resulting in an increase in sample consumption and a decrease in detection efficiency

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  • Method and apparatus for controlling ion reaction based on linear ion well
  • Method and apparatus for controlling ion reaction based on linear ion well
  • Method and apparatus for controlling ion reaction based on linear ion well

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Embodiment 1

[0044] This embodiment provides an ion reaction control method based on a linear ion trap, including the following steps:

[0045] Step 1: Applying a biphasic radio frequency voltage to four electrodes of the linear ion trap to form a radio frequency electric field; applying a DC voltage to different electrodes of the linear ion trap to form a bias electric field; while applying the radio frequency electric field and the bias electric field or Afterwards, the positive ions and negative ions are introduced into the ion trap, so that the positive ions and negative ions approach the electrode opposite to their own polarity and are stored in the linear ion trap;

[0046]After the positive ions and negative ions are generated, the positive and negative ions are respectively introduced into the interior of the linear ion trap from both ends of the linear ion trap by means of dual ion transmission. Under the action of the bias electric field and the radio frequency electric field, th...

Embodiment 2

[0052] A method for controlling ion reactions based on a linear ion trap provided in this embodiment includes

[0053] Step 1: Apply a radio frequency voltage to the electrodes of the linear ion trap to form a radio frequency electric field; apply a DC voltage to different electrodes of the linear ion trap to form a bias electric field; apply the radio frequency electric field and the bias electric field while or after positive ions and negative ions are introduced into the ion trap, so that the positive ions and negative ions approach the electrode opposite to their own polarity and store them in the linear ion trap;

[0054] After the positive ions and negative ions are generated, the positive and negative ions are respectively introduced into the interior of the linear ion trap from both ends of the linear ion trap by means of dual ion transmission. Under the action of the bias electric field and the radio frequency electric field, the positive ions and negative ions gradua...

Embodiment 3

[0062] This embodiment provides an ion reaction control device corresponding to the control method in Embodiment 1, which includes

[0063] A radio frequency voltage source is used to apply a radio frequency voltage to the electrodes of the linear ion trap to form a radio frequency electric field;

[0064] A direct current voltage source (DC), which is used to apply a direct current voltage to different electrodes of the linear ion trap to form a bias electric field;

[0065] A linear ion trap for receiving positive ions and negative ions at the same time or after applying said radio frequency electric field and bias electric field, and directing the positive ions and negative ions toward electrodes opposite in polarity to itself under the action of the radio frequency electric field and bias electric field close to and stored in the linear ion trap;

[0066] The excitation voltage source (AC) is used to apply the excitation voltage in the same direction as the DC voltage to ...

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Abstract

The invention provides a method and apparatus for controlling ionic reaction based on a linear ion well. The method includes the following steps: applying a radio frequency electric field and a biased electric field within the linear ion well so as to enable positive ions and negative ions to separate from each other and be stored in the linear ion well upon being simultaneously imported, then maintaining and changing the intensity of the electric field and the like parameters or repetitively applying and canceling the electric field so as to realize precise control of ion storage and reaction states, finally applying an excitation electric field and emitting out ions to be tested, and conducting simultaneous detection on the positive and negative ions through a detection device.

Description

technical field [0001] The invention relates to the technical field of mass spectrometry, in particular to an ion reaction control method based on a linear ion trap. Background technique [0002] Mass spectrometry is an analytical method that separates and detects compounds according to different mass-to-charge ratios (m / z) to identify components and structures. Due to its high specificity and sensitivity, mass spectrometry plays an increasingly important role in the field of biological analysis. Bio-mass spectrometry (Bio-MS) is a mass spectrometry technique applied to the analysis of biomolecules. and disulfide bond positioning, protein post-translational modification, quantitative proteome analysis, protein interaction studies, etc. In addition, biological mass spectrometry is also used in polysaccharide structure determination, oligonucleotide and nucleic acid analysis, microbial identification, drug development and other fields. [0003] Gas-phase ion reactions are w...

Claims

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Application Information

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IPC IPC(8): H01J49/42
CPCH01J49/426H01J49/4275
Inventor 江游贺木易方向熊行创徐伟黄泽建刘梅英
Owner NAT INST OF METROLOGY CHINA