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Cell implantation model for artificial corneal reconstruction

An artificial cornea and cell technology, applied in the field of medical research, can solve the problems of transplant failure, cell purity and density not meeting the requirements, etc., and achieve the effects of small cell interference, difficult displacement, and high success rate

Active Publication Date: 2016-10-26
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even if excellent seed cells are used, if the cell purity and density cannot meet the requirements during the planting process, it will lead to the failure of transplantation

Method used

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  • Cell implantation model for artificial corneal reconstruction
  • Cell implantation model for artificial corneal reconstruction
  • Cell implantation model for artificial corneal reconstruction

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Embodiment Construction

[0015] In order to facilitate the understanding of the working principle of the present invention, the following description will be given in conjunction with the drawings and embodiments.

[0016] Reference figure 1 , 2 As shown, the cell planting model 1 for artificial corneal reconstruction of the present invention mainly includes a carrier frame 10 and a supporting shell 20, wherein:

[0017] The carrier support 10 is used for cell planting, and includes a first planting surface 11 and a second planting surface 12. A closed ring-shaped fixing area 13 is provided on the outer edges of the first planting surface 11 and the second planting surface 12 as the present In a preferred embodiment of the invention, the width of the closed annular fixing area 13 is designed to be 1-2 mm.

[0018] The supporting shell 20 is used to support the carrier bracket 10, and includes a first tube 21, a second tube 22, and a third tube 23. The fixing area 13 is sandwiched and fixed between the first ...

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Abstract

The invention discloses a cell implantation model for artificial corneal reconstruction. The cell implantation model comprises a carrier stent for cell implantation and a support housing for supporting the carrier stent. The carrier stent of the model designed in the invention is fixed in the support housing made of a silica gel material, and then is placed in a culture dish for cell implantation; the support housing has good supporting effect on the carrier stent, especially thin-layer stents, so that the carrier stent is unlikely to shift and curl during implementation.

Description

Technical field [0001] The present invention relates to the technical field of medical research, in particular to a model for planting corneal endothelial cells and / or corneal epithelial cells on any carrier support for tissue engineering artificial corneal reconstruction Background technique [0002] The cornea is a transparent tissue located at the forefront of the eye, composed of epithelial cell layer, stromal layer and endothelial cell layer. Corneal epithelial cells (corneal epithelial cells) are susceptible to microbial invasion, mechanical trauma, chemical burns and thermal burns due to their special location and structure. Corneal limbal epithelial cells are the source of corneal epithelial cell renewal and regeneration. Many serious ocular surface diseases such as Stevens-Johnson syndrome and ocular cicatricial pemphigoid, eye infections and trauma can lead to the lack of limbal stem cells, which in turn leads to the loss of the ability to regenerate and repair the cor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00
CPCC12M21/08C12M23/48
Inventor 张志华刘堃刘海芸许迅张超
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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