A kind of amino acid-based polypeptide and its preparation method
An amino acid-based, amino acid-based technology, applied in the field of polymer chemistry, can solve the problems of long reaction cycle, practical application limitations, cumbersome synthesis process, etc.
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[0038] The present invention also provides a preparation method of amino acid-based clustering peptide, comprising:
[0039] Mix amino acid, aldehyde and isocyanide in organic solvent; or mix amino acid derivative, aldehyde and isocyanide in organic solvent to obtain amino acid-based clustering peptide. The reaction process is as follows:
[0040]
[0041] According to the present invention, amino acid or amino acid derivative, aldehyde and isocyanate are mixed in an organic solvent, the concentration of said amino acid or amino acid derivative is preferably 0.5-1 mole per liter, and polymerization is preferably performed at a temperature of 20-25°C After 48 to 96 hours, the organic solvent was removed in vacuum, the residual solid was dissolved in dichloromethane, and the solid obtained by sedimentation and centrifugation in petroleum ether was the amino acid-based polypeptide.
[0042] According to the present invention, described aldehyde is preferably that described al...
Embodiment 1
[0046] The preparation method of glycine-based aggregation peptide is as follows:
[0047]
[0048] Add glycine (10mmol), tert-butyl isocyanide (22mmol), methanol 20mL, benzaldehyde (22mmol) into a 50mL polymerization tube, polymerize at 20°C for 96h, remove volatile matter in a vacuum, and dissolve the residual solid in dichloro Settling and centrifuging in petroleum ether in methane, and drying, the obtained white solid is a glycine-based polymer peptide with a number average molecular weight of 3400 Daltons and a molecular weight distribution of 1.24.
[0049] figure 1 The NMR spectrum of the glycine-based clustering peptide prepared in Example 1 of the present invention ( 1 H NMR); figure 1 The glycine-based clustering peptide successfully prepared by the present invention is illustrated.
Embodiment 2
[0051] The preparation method of alanine-based aggregation peptide is as follows:
[0052]
[0053] Add alanine (10mmol), tert-butyl isocyanide (22mmol), methanol 20mL, and benzaldehyde (22mmol) into a 50mL polymerization tube, polymerize at 20°C for 96h, remove volatile matter in a vacuum, and dissolve the residual solid in Settling and centrifuging in petroleum ether in dichloromethane, and drying, the obtained white solid is alanine-based polymer peptide with a number average molecular weight of 3800 Daltons and a molecular weight distribution of 1.30.
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