Novel application of Alpha-mangostin

A technology of mangosteen flavonoids and uses is applied in the new use field of alpha-mangosteen flavonoids to achieve the effects of improving endothelial cell edema, improving insulin resistance, and reducing hepatic vacuolar degeneration

Inactive Publication Date: 2016-12-07
雷闽湘
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are no relevant reports on the effects of α-mangosteen flavonoids on islet cell function, insulin resistance, fatty liver and vascular endothelial function

Method used

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  • Novel application of Alpha-mangostin
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  • Novel application of Alpha-mangostin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. Research on islet function

[0032] 1. Experimental method

[0033]Type 2 diabetes model mice (8-week-old male db / db homozygous mice) were randomly divided into diabetes group and α-mangosteen group, and 8-week-old littermate wild-type mice were selected as normal control group. The α-mangosteen flavone group was injected intraperitoneally with 0.3 mg / kg of α-mangosteen flavone every day, and the normal control group and the diabetes group were given a considerable amount of solvent intraperitoneal injection. Observe the general conditions, drinking water, food intake, body weight, blood sugar and other indicators of mice in each group for a total of 12 weeks. When the experiment is terminated, an insulin tolerance test (Insulin tolerance test, ITT) experiment is performed, and fasting plasma is collected from each group for use. HOMA-IR, QUICKI-IR and HOMA-β indexes were calculated for the detection of blood glucose and insulin levels.

[0034] Where, HOMA...

Embodiment 2

[0080] Embodiment 2, research on vascular endothelial function

[0081] The mice in each group of Example 1 were taken to open their thoracotomy under anesthesia, and after taking blood from the heart, the thoracic aorta was quickly separated and cut, and placed in a place filled with 95% O 2 and 5% CO 2 Mixed gases in modified Kirschner's solution. Carefully cut off the surrounding connective tissue, remove the blood in the blood vessel, cut into a 3-4mm vascular ring, fix one end in the bath, and connect the other end to a tension transducer, and continuously record changes in vascular tension through the BUXCO biorecording system. Vascular loop placed in 8ml filled with 95% O 2 and 5% CO 2 In the water tank (37°C) of the modified Kirschner solution of the mixed gas, the Kirschner solution was replaced every 15 minutes. Resting tension is 1g, equilibrate for 60 minutes, add KCl (60mmol / L) to constrict blood vessels, wash 2-3 times, rebalance the vascular ring, and use ph...

Embodiment 3

[0087] Embodiment 3, the impact on fatty liver

[0088] Get respectively the liver of the mouse that embodiment 1 each group puts to death and carry out HE staining pathological examination, the results are shown in Figure 9 .

[0089] The results showed that the liver tissue structure of the normal control group was regular, and no obvious fatty degeneration of the liver was seen. The liver tissue of rats in the diabetic group showed obvious pathological changes of fatty liver, the structure of the hepatic lobule was not clear, and the liver cells were severely degenerated. But the steatosis in the α-mangosteen flavone group was lighter. Under the HE staining light microscope, it can be seen that the normal control group has no red staining; the diabetic group has a large area of ​​red staining; the red staining area of ​​the α-mangosteen flavonoid group is significantly smaller than that of the diabetic control group. It shows that α-mangosteen flavonoids can improve fat...

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Abstract

The invention relates to the field of traditional Chinese medicine and discloses novel application of Alpha-mangostin. The invention provides application of Alpha-mangostin in the preparation of drugs for improving islet cell functionality, insulin resistance and vascular endothelial functionality. Experiments show that Alpha-mangostin can improve islet cell functionality and insulin resistance, can improve vascular tissue form damage and endothelial cell edema, necrosis, shedding and structural distortion, and can reduce liver vacuolar denaturation. It is indicated that Alpha-mangostin can improve islet cell functionality, vascular endothelial functionality and fatty liver.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to the new application of α-mangosteen flavone, especially the effect of α-mangosteen flavonoid on islet cell function, insulin resistance, fatty liver and vascular endothelial function. Background technique [0002] Mangosteen (Garcinia mangostana L.), known as the "Queen of Fruits", is the fruit of the evergreen tree mangosteen of the genus Garcinia in the family Guttiferae. Originating in Indonesia and Malaysia, it is a typical tropical fruit, mainly distributed in Southeast Asian countries such as Thailand, Vietnam, Malaysia, Indonesia, and the Philippines, and widely cultivated in Guangxi, Hainan and other regions of China. Mangosteen peel has been used as traditional Thai medicine for the treatment of abdominal pain, diarrhea, dysentery, infectious trauma, suppuration, chronic ulcer, leucorrhea, gonorrhea and other diseases. Moreover, many studies have found that m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P5/50A61P1/16
CPCA61K31/352
Inventor 雷闽湘江盟李纯黄珊雅段望刘泽灏肖袁
Owner 雷闽湘
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