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A high-fat feed and animal model technology, applied in the direction of animal feed, animal feed, additional food elements, etc., can solve the problems of limited model applicability, genetic relationship, animal damage, etc., to achieve long maintenance time, high morbidity, The effect of avoiding harm
Inactive Publication Date: 2016-12-14
广州市饲料研究所 +1
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[0005] The genetic relationship between rats and humans is far away, and the applicability of the model has certain limitations. In addition, the current artificially induced animal disease models mostly use drug induction, which causes great harm to animals.
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Embodiment 1
[0024] The preparation of embodiment 1 high-fat feed
[0025] High-fat feed: corn 32.5%, puffed soybean 22%, wheat bran 2%, fish meal 7%, flour 14%, alfalfa powder 2%, lard 12%, cholesterol 1%, white sugar 5%, vitamin premix 0.05%, mineral premix 2%, big ingredients (corn, puffed soybeans, wheat bran, fish meal, flour, alfalfa powder, etc.) are respectively pulverized in a pulverizer, passed through a 80-mesh sieve, and mixed in a mixing device Finally, add cholesterol, white sugar, vitamins and minerals and mix well, then add lard and pure water and stir well to make glutinous rice ball-shaped feed. The protein content of the feed is 17%, and the fat content is 20%.
[0026] The mineral premix was provided by Guangzhou Jinbaihe Feed Technology Co., Ltd., and the vitamin premix was provided by Guangzhou Aibonong Feed Co., Ltd. The rest of the ingredients were also obtained from commercial sources.
Embodiment 2
[0027] Example 2 Type II diabetes animal model
[0028] The 20 rhesus monkeys used in the experiment are all male monkeys, aged between 8 and 12 years old, and weighing between 9 and 14 kg. Before the test, the fasting blood glucose (FPG) of all animals was lower than 5mmol / L (90mg / dL).
[0029] Among the 20 rhesus monkeys, 10 were selected as the control group, and 10 of them were used as the model group of the rhesus type II diabetes model induced by simple diet.
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Abstract
The invention discloses a high fat feed and a type II diabetes animal model. The high fat feed comprises the following raw materials: corn, expanded soybean, wheat bran, fish meal, flour, alfalfa powder, lard, cholesterol, white granulated sugar, vitamin premix, and mineral premix. The provided high fat feed can induce rhesus monkeys to generate the symptoms of type II diabetes. The harm caused by drug induction to animals can be avoided. The interference caused by drugs in the development of drugs for treating diabetes can also be eliminated. The dosage in drug induction is hard to control, and the dietary induction effectively solves the abovementioned problem. The generated model has the characteristics of high incidence rate, long maintenance time, and stability, and animals will not die easily. A standard animal model is provided for the researches on type II diabetes.
Description
technical field [0001] The invention relates to the technical field of animal model preparation, in particular to a high-fat feed for modeling and an animal model of type II diabetes. Background technique [0002] Diabetes mellitus (DM) is the third most serious disease in the world after cardiovascular and cerebrovascular diseases and tumors, and the incidence rate in my country is increasing year by year. Diabetes mellitus is a common disease. Due to insulin deficiency or / and insulin action (resistance), it leads to increased blood sugar and other metabolic disorders. Genetic factors and environmental factors each account for 50% of the pathogenic factors. Among the sick population in my country, type I diabetes accounts for 5.6%, type II diabetes accounts for 93.7%, and other types of diabetes only account for 0.7%. [0003] Type II diabetes mellitus (DM2) refers to a type of diabetes mellitus characterized by defects in insulin secretion and insulin resistance as the ma...
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