Nadolol gel for treating infantile hemangioma and preparation method thereof

An infant hemangioma and gel technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, antineoplastic drugs, etc., can solve the problems of long half-life, easy accumulation of drug side effects, etc.

Inactive Publication Date: 2016-12-14
GANNAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention proposes to prepare nadolol gel for the treatment of infantile hemangioma for the first time. Although there are reports of nadolol for treating infantile hemangioma, it takes effect after being orally absorbed into the blood

Method used

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  • Nadolol gel for treating infantile hemangioma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Prescription: Nadolol 1.0%, Carbomer 0.5%, Sodium Hydroxide 0.2%, Propylene Glycol 1.5%, Ethyl Paraben 0.1%, Glycerin 4.0%, the balance is water

[0018] Preparation:

[0019] 1) Put the carbomer in the container, add water to disperse, soak for 4 hours, and get the carbomer dispersion for later use;

[0020] 2) Add sodium hydroxide to an appropriate amount of water to prepare a sodium hydroxide solution with a concentration of 0.4g / L, and slowly add the sodium hydroxide solution to the carbomer dispersion to prepare a blank gel;

[0021] 3) Dissolve ethylparaben in propylene glycol and glycerin, then slowly add to the blank gel, and stir evenly;

[0022] 4) Dissolve nadolol in an appropriate amount of water, slowly add it to the above gel, add water to the full amount, and stir evenly.

Embodiment 2

[0024] Prescription: Nadolol 4.0%, Carbomer 2.0%, Sodium Hydroxide 0.8%, Propylene Glycol 4.5%, Ethyl Paraben 0.2%, Glycerin 8.0%, the balance is water

[0025] Preparation:

[0026] 1) Put the carbomer in the container, add water to disperse, soak for 6 hours, and get the carbomer dispersion for later use;

[0027] 2) Add sodium hydroxide to an appropriate amount of water to prepare a sodium hydroxide solution with a concentration of 0.4g / L, and slowly add the sodium hydroxide solution to the carbomer dispersion to prepare a blank gel;

[0028] 3) Dissolve ethylparaben in propylene glycol and glycerin, then slowly add to the blank gel, and stir evenly;

[0029] 4) Dissolve nadolol in an appropriate amount of water, slowly add it to the above gel, add water to the full amount, and stir evenly.

Embodiment 3

[0031] Prescription: Nadolol 1.0-3.0%, Carbomer 0.5-1.5%, Sodium Hydroxide 0.2-0.6%, Propylene Glycol 2.0%, Ethylparaben 0.18%, Glycerin 6.0%, and the balance is water.

[0032] Preparation:

[0033] 1) Put the carbomer in the container, add water to disperse, soak for 8 hours, and get the carbomer dispersion for later use;

[0034] 2) Add sodium hydroxide to an appropriate amount of water to prepare a sodium hydroxide solution with a concentration of 0.4g / L, and slowly add the sodium hydroxide solution to the carbomer dispersion to prepare a blank gel;

[0035] 3) Dissolve ethylparaben in propylene glycol and glycerin, then slowly add to the blank gel, and stir evenly;

[0036] 4) Dissolve nadolol in an appropriate amount of water, slowly add it to the above gel, add water to the full amount, and stir evenly.

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PUM

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Abstract

The invention belongs to the technical field of drug preparation and particularly relates to nadolol gel for treating infantile hemangioma and a preparation method thereof. The nadolol gel for treating infantile hemangioma comprises, by weight: 1.0-4.0 parts of nadolol, 0.5-2.0 parts of carbomer, 0.2-0.8 part of sodium hydroxide, 1.5-4.5 parts of propylene glycol, 0.1-0.2 part of ethylparaben, 4.0-8.0 parts of glycerol and the balance of water. Compared with the prior art, the nadolol gel for treating infantile hemangioma has good therapeutic effect, is convenient to use, is used at low dosage, rarely accumulates in the human body, and has small side effect.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a nadolol gel for treating infantile hemangioma and a preparation method thereof. Background technique [0002] Nadolol is nadolol, which is mainly used to treat hypertension, angina pectoris and arrhythmia, expand renal arteries, and improve renal hemodynamics. Nadolol is a non-selective β-receptor anion blocker, does not have intrinsic sympathomimetic activity and membrane stabilization, is hydrophilic and is extremely insoluble in fat. Its pharmacokinetics is characterized by a long half-life of up to 17-24 hours. [0003] Infant hemangiomas (infant hemangiomas, IH) are congenital benign tumors or vascular malformations, most common in infants at birth or shortly after birth, which originate from residual embryonic hemangioblasts. The hazards of infantile hemangiomas are diverse, most of which can affect body functions or damage appearance, and a sma...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/138A61K47/32A61P35/00
CPCA61K9/0014A61K9/06A61K31/138A61K47/32
Inventor 刘潜徐仙赟刘海金黄海金李林福陶超宁慧婷林子钟佳成
Owner GANNAN MEDICAL UNIV
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