Nifedipine pharmaceutical composition

A technology of nifedipine and its composition, which is applied in the field of pharmaceutical composition and its application in biomedicine, can solve the problems that have not yet been reported on the correlation between nifedipine and hemolytic anemia, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-12-14
范瑶飞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation betw...

Method used

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  • Nifedipine pharmaceutical composition
  • Nifedipine pharmaceutical composition
  • Nifedipine pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0016] Separation method: (a) Smilax smilax (2kg) was crushed, extracted with 90% ethanol under heat reflux (15L×3 times), the extracts were combined, concentrated to no alcohol smell (3L), and petroleum ether (3L×3 times) ), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a ) in the ethyl acetate extract with D101 type macroporous resin to remove impurities, first eluted with 35% ethanol for 8 column volumes, then 90% ethanol for 12 column volumes, collected 90% eluate, and concentrated under reduced pressure Obtain 90% ethanol elution concentrate; (c) in step (b), 90% ethanol elution concentrate is separated with normal phase silica gel, with volume ratio successively being 120:1 (11 column volumes), 60:1 (9 column volume), 30:1 (9 column volumes) and 15...

Embodiment 2

[0019] Embodiment 2: pharmacological action

[0020] In this example, 2% phenylhydrazine was used to prepare an anemic mouse model, and the anti-anemia effect of the drug on increasing the number of red blood cells and increasing the content of hemoglobin was observed.

[0021] 1. Materials and methods

[0022] 1.1 Animals

[0023] Kunming mice, weighing 18-22 g, half male and half male, were provided by Experimental Animal Center of Henan Province.

[0024] 1.2 Reagents and samples

[0025]Nifedipine was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Phenylhydrazine hydrochloride was purchased from Sigma.

[0026] 1.3 Instruments

[0027] The blood cell analyzer NIKON KOHDEN Celltac is produced in Japan; the pH meter HANNApH211 is produced in Italy.

[0028] 1.4 Mouse grouping and model preparation

[0029] The mice were randomly divided into 4 group...

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PUM

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Abstract

The invention discloses a nifedipine pharmaceutical composition. The nifedipine pharmaceutical composition is prepared from nifedipine and a natural product compound (I) of a novel structure, and the nifedipine compound (I) has a treatment effect on haemolytic anaemia when acting independently; the treatment effect on haemolytic anaemia is further improved when nifedipine and the compound (I) act jointly, nifedipine and the compound (I) can be developed into medicine for treating haemolytic anaemia, and compared with the prior art, an outstanding substantive feature and a remarkable progress are achieved. The compound (I) is shown in the description.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of nifedipine, in particular to a pharmaceutical composition of nifedipine and its application in biomedicine. Background technique [0002] Nifedipine inhibits Ca 2+ Internal flow can relax vascular smooth muscle, dilate coronary arteries, increase coronary blood flow, improve myocardial tolerance to ischemia, and at the same time expand peripheral arterioles, reduce peripheral vascular resistance, and thereby lower blood pressure. It is clinically used to prevent and treat angina pectoris of coronary heart disease, especially variant angina pectoris and angina pectoris caused by coronary artery spasm. It has no adverse effect on respiratory function, so it is suitable for patients with angina pectoris with obstructive airway diseases, and its curative effect is better than that of beta-receptor antagonists. It is also suitable for various types of hypertension, and h...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K31/366C07D309/38A61P7/06
CPCA61K31/4422A61K31/366A61K36/90C07D309/38
Inventor 范瑶飞
Owner 范瑶飞
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