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Application of natural p53 regulator Jatamanvaltrate P

A technology of regulators and uses, applied in the field of uses of the natural p53 regulator Jatamanvaltrate P, can solve problems such as incomplete elucidation of molecular mechanisms and the like

Active Publication Date: 2016-12-21
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, although Chinese herbal medicines and natural products have been widely used in the treatment of breast cancer, most of them are currently treated with adjuvant chemical drugs, and the molecular mechanism of their effects has not been fully elucidated.

Method used

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  • Application of natural p53 regulator Jatamanvaltrate P
  • Application of natural p53 regulator Jatamanvaltrate P
  • Application of natural p53 regulator Jatamanvaltrate P

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Experimental program
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Embodiment

[0020] The natural product Jatamanvaltrate P (abbreviated as JP) preparation method: 7kg of spider vetch root and rhizome, crushed into coarse powder, cold-soaked with 95% ethanol for 48h, extracted by percolation, suspended in water, extracted 3 times with equal volume of dichloromethane , until the color of the extract is lighter. About 190 g of the dichloromethane extract was taken and separated by silica gel column chromatography, and eluted with petroleum ether-ethyl acetate (40:1-0:1) gradient to obtain a total of 11 fractions of Fr1-11. Take about 5 g of Fr7, and carry out reverse-phase medium-pressure column chromatography separation, use 40-60 micron octadecyl bonded phase silica gel as filler, and elute isocraticly with 60, 70, 75, 80, and 90% methanol respectively , 2000mL / gradient, 100mL / bottle, collected part of fractions eluted with 90% methanol, and recovered the solvent under reduced pressure to obtain about 106.1 mg of light yellow oily substance. Take about ...

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Abstract

The invention discloses application of a natural p53 regulator Jatamanvaltrate P and application of the Jatamanvaltrate P to preparation of a medicine for treating breast cancer. The invention discloses the application of the Jatamanvaltrate P to the preparation of the medicine for treating the breast cancer for the first time, so as to find a new therapeutic scheme for the breast cancer and provide a theoretical foundation for clinically utilizing Jatamanvaltrate P.

Description

technical field [0001] The present invention relates to a new application of a natural product, in particular to an application of a natural p53 regulator Jatamanvaltrate P. Background technique [0002] Breast cancer (mammary carcinoma) is a disease in which breast ductal epithelial cells lose their normal characteristics and abnormally proliferate under the action of various internal and external carcinogenic factors, so that they exceed the limit of self-repair and become cancerous. As a heterogeneous disease, It showed a variety of pathological features and the main clinical manifestation was breast mass. The etiology of its pathogenesis is a process of accumulation of multiple factors and multiple mutations, and its occurrence is not yet clear. Breast cancer is the number one killer of female cancer in the world. About 1.2 million women worldwide suffer from breast cancer every year, and more than 500,000 of them die. Especially in developed countries such as Europe a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P35/00A61P15/14
CPCA61K31/352
Inventor 赵华军杨波朱瑞赵亚萍
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY