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Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost

A nucleation and ice crystal technology, applied in the direction of drying gas arrangement, drying, drying machine, etc., can solve the problem of increasing the unevenness between bottles of freeze-dried products

Active Publication Date: 2016-12-21
MILLROCK TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As the shelves of the freeze dryer are continuously cooled, the time lag between the first vial freezing and the last vial freezing creates vial-to-vial temperature differences, which increases vial-to-vial inhomogeneity in the freeze-dried product

Method used

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  • Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost
  • Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost
  • Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost

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Embodiment Construction

[0017] As in figure 1 As shown in, the apparatus 10 for performing the method of the present invention includes a freeze dryer 12 having one or more shelves 14 for supporting bottles of products to be freeze-dried. The condensation chamber 16 is connected to the freeze dryer 12 through a steam port 18 having an isolation valve 20 having any suitable structure between the condensation chamber 16 and the freeze dryer 12. Preferably, the isolation valve 20 is constructed as a two-way sealed vacuum.

[0018] The vacuum pump 22 is connected to the condensing chamber 16 through a valve 21, which is located between them and has any suitable structure. The condensing chamber 16 has a filling valve 24 and a vent valve 27 and a filter 28 with any suitable structure, and the freeze dryer 12 has a control valve 25 and a release valve 26 with any suitable structure.

[0019] As an illustrative example, the operation of the device 10 according to an embodiment of the method of the present inven...

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Abstract

A method of controlling and enhancing the nucleation of product in a freeze dryer is provided, wherein the product is maintained at a predetermined temperature and pressure in a chamber of the freeze dryer, and a predetermined volume of condensed frost is created on an inner surface of a condenser chamber separated from the product chamber and connected thereto by a vapor port. The opening of the vapor port into the product chamber when the condenser chamber has a pressure that is greater than that of the product chamber creates gas turbulence that breaks down the condensed frost into ice crystals that rapidly enter the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber.

Description

[0001] This application is a continuation of US Patent Application No. 13 / 572,978 filed on August 13, 2012, and the entire content of the patent application is incorporated into this application by citation. Technical field [0002] The present invention relates to a method for controlling nucleation in the freezing step of a freeze-drying cycle, and in particular to a method for triggering spontaneous nucleation of all bottles in a freeze-drying device by using pressure difference ice mist distribution at a predetermined nucleation temperature. Background technique [0003] It is a strong demand in this technical field to control the general random process of nucleation in the freeze-drying process or the freezing stage of the freeze-drying method to reduce the necessary processing time to complete the freeze-drying and improve the product uniformity between finished bottles and bottles. In a typical pharmaceutical freeze-drying process, many bottles containing the same aqueous so...

Claims

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Application Information

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IPC IPC(8): F26B5/06F26B21/00F26B25/00
CPCF26B5/06
Inventor 凌伟佳
Owner MILLROCK TECH
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