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Preparation and application of a zif-8@phthalocyanine zinc composite material

A technology of ZIF-8 and composite materials, applied in wave energy or particle radiation treatment materials, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of phthalocyanine photodynamic activity reduction, loss of light Dynamic activity and other issues, to achieve superior photodynamic activity, uniform morphology, and solve the effect of easy aggregation

Active Publication Date: 2019-04-05
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most important impact is that aggregation provides a very effective non-radiative energy consumption method, so that the energy absorbed by phthalocyanine after irradiation is mainly used for its own depolymerization, and cannot effectively generate excited triplet states and then produce 1 o 2 , so that the photodynamic activity of phthalocyanine is greatly reduced, and even the photodynamic activity is lost in severe cases.

Method used

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  • Preparation and application of a zif-8@phthalocyanine zinc composite material
  • Preparation and application of a zif-8@phthalocyanine zinc composite material
  • Preparation and application of a zif-8@phthalocyanine zinc composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A preparation method of ZIF-8@phthalocyanine zinc composite material, the specific steps are:

[0033] 1) Preparation of ZIF-8@Zinc Phthalocyanine Composite Material: Weigh 150mg Zn(NO 3 ) 2 ·(H 2 O) 6 , dissolved in 7.5mL of methanol, 330mg of 2-methylimidazole was dissolved in 7.5mL of methanol, 10mg of zinc phthalocyanine (zinc phthalocyanine composite material) was dissolved in 1mL of N,N dimethylformamide, fully ultrasonicated Dissolve completely;

[0034] 2) Pour the above three fully dissolved solutions into a jar, then add 4mg of surfactant CTAB, and stir for 0.5h in one pot at room temperature;

[0035] 3) After the reaction is complete, collect the crude product by centrifugation at a centrifugation speed of 7000 rpm / min for 10 min; wash and purify the crude product with methanol, 15 mL each time, and wash three times;

[0036] 4) The obtained product was vacuum-dried in an oven at 60°C for 2 hours, and ground in an agate mortar to obtain the final produc...

Embodiment 2

[0038] A preparation method of ZIF-8@phthalocyanine zinc composite material, the specific steps are:

[0039] 1) Preparation of ZIF-8@Zinc Phthalocyanine Composite Material: Weigh 150mg Zn(NO 3 ) 2 ·(H 2 O) 6 , dissolved in 7.5mL of methanol, 330mg of 2-methylimidazole was dissolved in 7.5mL of methanol, 10mg of zinc phthalocyanine (zinc phthalocyanine composite material) was dissolved in 1mL of N,N dimethylformamide, fully ultrasonicated Dissolve completely;

[0040] 2) Pour the above three fully dissolved solutions into a jar, then add 4mg of surfactant CTAB, and stir for 0.25h in one pot at room temperature;

[0041] 3) After the reaction is complete, collect the crude product by centrifugation at a speed of 6000rpm / min for 15 minutes; wash and purify the crude product with methanol, 15 mL each time, and wash three times;

[0042] 4) The obtained product was vacuum-dried in an oven at 40°C for 3.5 hours, and ground in an agate mortar to obtain the final product.

Embodiment 3

[0044] A preparation method of ZIF-8@phthalocyanine zinc composite material, the specific steps are:

[0045] 1) Preparation of ZIF-8@Zinc Phthalocyanine Composite Material: Weigh 150mg Zn(NO 3 ) 2 ·(H 2 O) 6 , dissolved in 7.5mL of methanol, 330mg of 2-methylimidazole was dissolved in 7.5mL of methanol, 10mg of zinc phthalocyanine (zinc phthalocyanine composite material) was dissolved in 1mL of N,N dimethylformamide, fully ultrasonicated Dissolve completely;

[0046] 2) Pour the above three fully dissolved solutions into a jar, then add 4 mg of surfactant CTAB, and stir for 1 hour at room temperature;

[0047] 3) After the reaction is complete, collect the crude product by centrifugation at a centrifugation speed of 10,000 rpm / min for 8 min; wash and purify the crude product with methanol, 15 mL each time, and wash three times;

[0048] 4) The obtained product was vacuum-dried in an oven at 70°C for 2.5 hours, and ground in an agate mortar to obtain the final product.

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Abstract

The invention discloses preparation and application of a ZIF-8@zinc phthalocyanine composite. According to a preparation method for the ZIF-8@zinc phthalocyanine composite, the composite is synthesized by using a one-pot method at room temperature with Zn(NO3)2.(H2O)6 as a metal source, 2-methylimidazole as a ligand, CTAB as a surfactant and zinc phthalocyanine as a photosensitizer. The prepared ZIF-8@zinc phthalocyanine composite has the advantages of uniform particle distribution, good crystallization degree and good photodynamic activity. The preparation method has the advantages of simple operation, high yield, good product stability and the like, has wide application prospect and broadens the application scope of ZIF materials.

Description

technical field [0001] The invention belongs to the field of metal organic framework materials used as drug transport, and specifically relates to the preparation of a metal organic framework material ZIF-8@phthalocyanine zinc composite material and its application in photodynamic therapy. Background technique [0002] Metal-organic frameworks (Metal Organic Frameworks, referred to as MOFs) are a type of organic-inorganic hybrid materials, also known as coordination polymers (coordination polymers), which are composed of bridged multi-dentate organic ligands (mainly aromatic polyacids) and polyalkali) and metal centers (metal ions or metal oxygen clusters) through coordination self-assembly to form a porous material with a periodic network structure. Due to the special composition of MOFs, its properties are different from both inorganic porous materials and general organic complexes. It has both the flexibility of organic materials and the rigidity of inorganic materials. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/69A61P35/00
CPCA61K41/0076
Inventor 薛金萍年夫宇叶焕年
Owner FUZHOU UNIV
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