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Application of a Steam Heating Method in Freeze Drying

A steam and drying process technology, applied in drying technology and its application fields, can solve many problems, and achieve the effects of accelerated evaporation, short drying time, and shortened drying time

Active Publication Date: 2019-03-05
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also reports in the literature that microwave radiation is used for heat transfer, but there are not many commercialized ones at present.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: the freeze-drying method of fritillaria fluid extract

[0028] 1) Dosing and pre-freezing: Take 50Kg of fritillaria fluid extract with a relative density of 1.05 (50°C) and put it in a freeze-drying cabinet, keep cooling down to -5°C within 0.5h, and maintain this temperature for 1h;

[0029] 2) Freezing and system balance: After the pre-freezing is completed, continue to cool down within 0.5 hours, reduce the temperature of the plate layer in the freeze-drying cabinet to -15°C, and maintain it at -15°C for 0.5h, and then maintain the plate layer Keep the temperature constant, vacuumize and depressurize to 2Pa;

[0030] 3) Sublimation: Keep the temperature of the plate layer constant, and continuously or intermittently pass into the cabinet the steam with an instantaneous volume of 0.0005 times the volume of the cavity to increase the vacuum degree to an average of 100Pa (the maximum instantaneous pressure fluctuation range does not exceed 650Pa), and main...

Embodiment 2

[0034] Embodiment 2: the freeze-drying method of dehydrodulcitol

[0035] 1) Pre-freezing: Add dulcitol to tert-butanol containing 99.9% of 2-methyl-2-propanol and 0.1% water content, dissolve at 35°C to make a 20% solution, filter, The filtrate is divided into open containers, placed in a freeze-drying cabinet, continuously cooled to 10°C within 0.25h, and maintained at this temperature for 0.25h;

[0036] 2) Freezing and system balance: after the end of pre-freezing, continue to cool down within 1 hour, lower the temperature in the freeze-drying cabinet to -5°C, and maintain this temperature for 0.5 hours, and reduce the pressure in the freeze-drying cabinet Adjust to 2Pa~10Pa;

[0037] 3) Sublimation: inject sterile steam to keep the vacuum at 150Pa for 3 hours;

[0038] Keep the above conditions unchanged, increase the temperature of the inner layer of the freeze-drying cabinet from the base temperature of -5°C to 0°C within 3 hours, and keep it at this temperature for 2...

Embodiment 3

[0041] Embodiment 3: the freeze-drying method of glycine solution

[0042] 1) Pre-freezing: add glycine to water and dissolve at 50°C to make a 20% solution, filter, pack the filtrate into open containers, put it in a freeze-drying cabinet, and keep cooling down to -5°C within 0.25h. And maintain at this temperature for 0.25h;

[0043] 2) Freezing and system balance: After the pre-freezing is completed, continue to cool down within 1 hour, lower the temperature in the freeze-drying cabinet to -15°C, and maintain this temperature for 0.5 hours, and reduce the pressure in the freeze-drying cabinet Adjust to 2Pa~10Pa;

[0044] 3) Sublimation: inject sterile steam to keep the vacuum at 150Pa for 3 hours;

[0045]Keep the above conditions unchanged, raise the temperature of the inner layer of the freeze-drying cabinet from the base temperature of -15°C to 0°C within 3 hours, and keep it at this temperature for 2 hours;

[0046] 4) Analysis: After the sublimation is completed, ch...

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PUM

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Abstract

The invention relates to application of a convectional heat transfer mode to the material freeze drying process. An application method is mainly characterized in that in the traditional freeze drying process, when solid water (or other solvents) starts to vaporize, a proper amount of steam is led to give steam latent heat to the solid water, so that the solid water is sublimated to vapor in an accelerated mode; and meanwhile, by utilizing kinetic energy which is released when the steam expands instantly, the vapor gets rid of the restraint of surface tension and quickly flees from the surfaces of materials to be discharged out of a freeze drying cavity, and therefore the purposes of achieving complete freeze drying and shortening the drying time are achieved.

Description

technical field [0001] The invention relates to the field of drying technology and its application, in particular to the application of a steam heating method in the freeze-drying process of materials. Background technique [0002] Freeze-drying technology is a high-tech processing technology for color protection, freshness and quality preservation of food and medicine. It is considered to be one of the best and most advanced drying technologies at present, and it is referred to as freeze-drying technology. With the development of science and technology and social progress, the people's demand for health protection is constantly increasing, and various advanced science and technology are applied to the production of medicines. Freeze-drying technology has high stability and Biological activity is favored by pharmaceutical manufacturers. [0003] The freeze-drying process is mainly composed of five links: drug preparation, pre-freezing, sublimation drying, desorption and dry...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): F26B5/06
Inventor 黄宇声刘冠萍徐卓张栩颜陈勇贤英越陈苑君易燕群
Owner GUANGXI WUZHOU PHARMA GRP
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