Novel liver cirrhosis or liver fibrosis marker

A technology for substances and liver diseases, applied in the field of biomedicine, can solve problems such as disagreement on the role of GP73
CN106405104AActive Publication Date: 2017-02-15PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PEKING UNIV
Publication Date
2017-02-15

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Abstract

The invention relates to the field of diagnosis and treatment of liver cirrhosis and liver fibrosis, in particular to application of Golgi protein 73(GP73) and matter for detecting the concentration of the Golgi protein 73(GP73) in preparation of products for screening or auxiliarily diagnosing liver cirrhosis or liver fibrosis related diseases or products for auxiliarily judging prognosis of the diseases. It is proved that the Golgi protein 73(GP73) can serve as a novel liver cirrhosis marker, also has diagnosis value on liver cirrhosis caused by non-b hepatitis virus infection, and has no diagnosis value on primary liver cancer.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and relates to a new application of a substance for detecting the concentration of Golgi protein 73 (GP73) and an application of the Golgi protein 73 (GP73) in preparing products for screening and diagnosing liver cirrhosis or liver fibrosis. Background technique

[0002] In 2000, Kladney et al. discovered Golgi protein 73 (GP73) when studying adult giant cell hepatitis, and it has been 16 years so far (Kladney RD, Bulla GA, Guo L, et al. Gene. 65). GP73 is a transmembrane glycoprotein with 402 amino acids and a relative molecular weight of 73kDa, also known as type II Golgi membrane protein (Golgiphosphoprotein 2, Golph2) and Golgi membrane protein 1 (Golgi membrane protein 1, Golm1). It is usually located in the trans-Golgi complex, and the gene encoding GP73 protein is located on chromosome 9, with a total length of 3080 nucleotides, and the coding region is located at 199-1404nt. GP73 is expresse...

Claims

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