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Novel liver cirrhosis or liver fibrosis marker

A technology for substances and liver diseases, applied in the field of biomedicine, can solve problems such as disagreement on the role of GP73

Active Publication Date: 2017-02-15
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in fact, scholars at home and abroad have different opinions on the clinical role of GP73 in liver cancer.

Method used

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  • Novel liver cirrhosis or liver fibrosis marker
  • Novel liver cirrhosis or liver fibrosis marker
  • Novel liver cirrhosis or liver fibrosis marker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Comparison of serum GP73, AFP, AFP-L3, and AFP-L3 in the diagnosis of primary liver cancer

[0038] 1) Baseline data of research subjects and samples

[0039] The blood samples came from: 805 cases of hepatitis patients; 2015 cases of liver cirrhosis patients; 1102 cases of liver cancer patients, a total of 3922 patients. The specific information of the patients is shown in Table 1.

[0040] The samples were all serum from clinically confirmed patients. These three clinical samples were provided by the 302nd Hospital of the People's Liberation Army. The patients visited the 302nd Hospital of the People's Liberation Army from December 2013 to December 2014.

[0041] 2) Statistical methods

[0042] The SPSS21.0 (SPSS, Chicago, Illinois, USA) statistical software was used for statistical analysis, the continuous variable was selected according to its distribution characteristics, and the quantitative data approximately obeying the normal distribution was used ...

Embodiment 2

[0052] Example 2 Distribution characteristics of serum GP73, AFP, and AFP-L3 (%) in patients with hepatitis, liver cirrhosis and liver cancer

[0053] The research objects and statistical methods are the same as in Example 1. In the experiment, the change trend of AFP, AFP-L3(%) and GP73 in patients with hepatitis, cirrhosis and liver cancer was described by interquartile range. The results showed that the change trend of GP73 in hepatitis, cirrhosis and liver cancer was more obvious. However, liver cancer cannot be distinguished from patients with hepatitis and cirrhosis. AFP and AFP-L3(%) only change significantly in patients with liver cancer, which can well distinguish liver cancer from patients with hepatitis and cirrhosis. See table 3.

[0054] Table 3 Interquartile range of GP73, AFP, AFP-L3 (%) in patients with hepatitis, cirrhosis and liver cancer

[0055]

Embodiment 3

[0056] Example 3 Comparison of serum GP73 and LSM, FIB4, APRI in the diagnosis of liver cirrhosis

[0057] The research objects and statistical methods are the same as in Example 1.

[0058] The results of this part show that the sensitivity and specificity of GP73 in diagnosing liver cirrhosis are 83.97% and 93.54%, respectively, and the area under the curve is 0.927 (95% CI, 0.917-0.937) ( figure 2 ), its diagnostic value is better than that of LSM, FIB-4 index, and platelet (PLT) ratio index APRI of liver stiffness, as shown in Table 4, which shows that GP73 has a strong ability to distinguish patients with liver cirrhosis.

[0059] Table 4 Diagnostic value of GP73, LSM, APRI and FIB4 for liver cirrhosis

[0060]

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Abstract

The invention relates to the field of diagnosis and treatment of liver cirrhosis and liver fibrosis, in particular to application of Golgi protein 73(GP73) and matter for detecting the concentration of the Golgi protein 73(GP73) in preparation of products for screening or auxiliarily diagnosing liver cirrhosis or liver fibrosis related diseases or products for auxiliarily judging prognosis of the diseases. It is proved that the Golgi protein 73(GP73) can serve as a novel liver cirrhosis marker, also has diagnosis value on liver cirrhosis caused by non-b hepatitis virus infection, and has no diagnosis value on primary liver cancer.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a new application of a substance for detecting the concentration of Golgi protein 73 (GP73) and an application of the Golgi protein 73 (GP73) in preparing products for screening and diagnosing liver cirrhosis or liver fibrosis. Background technique [0002] In 2000, Kladney et al. discovered Golgi protein 73 (GP73) when studying adult giant cell hepatitis, and it has been 16 years so far (Kladney RD, Bulla GA, Guo L, et al. Gene. 65). GP73 is a transmembrane glycoprotein with 402 amino acids and a relative molecular weight of 73kDa, also known as type II Golgi membrane protein (Golgiphosphoprotein 2, Golph2) and Golgi membrane protein 1 (Golgi membrane protein 1, Golm1). It is usually located in the trans-Golgi complex, and the gene encoding GP73 protein is located on chromosome 9, with a total length of 3080 nucleotides, and the coding region is located at 199-1404nt. GP73 is expresse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/085G01N33/576G01N33/5767G01N33/57438G01N33/68
Inventor 鲁凤民姚明解赵景民
Owner PEKING UNIV
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