Method for enhancing photostability of folic acid

A technology of folic acid and chlorogenic acid, applied in the directions of pharmaceutical formulations, acid-containing food ingredients, organic active ingredients, etc., can solve the problems of limited industrial application and high cost of raw materials, achieve easy industrialization and application, enhance photostability, inhibit light Degradation effect

Active Publication Date: 2017-02-22
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology improves how we use certain compounds called benfimidazole (BZ) that improve its ability to resist damage caused from UV ray exposure during storage on food products such as fruits and vegetables. By adding Bz to these compositions, they have improved resistance against decomposition due to sunlight over time without losing their effectiveness.

Problems solved by technology

This patents discuss how follicular acid (folate) may cause damage when taken up through sunlight exposure. It was found that adding beta cyclodextrine called α - cyclodextran together with folicum intake could prevent decomposition during storage without losing any ability for folic Acid to function properly within biology systems such as cell metabolism. Additionally, there were experiments conducted showing that combining folicacilicate with other chemical compounds like calcium sulfite resulted in better protection against photobleaching compared to just supplementing each ingredient separately.

Method used

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  • Method for enhancing photostability of folic acid
  • Method for enhancing photostability of folic acid
  • Method for enhancing photostability of folic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Put the folic acid solution with a mass concentration of 1g / L and any of the cinnamic acid-ethanol solution or hydroxycinnamic acid derivative-ethanol solution with a mass concentration of 1g / L in a phosphate buffer solution with a pH of 6.0-8.0 Mix and adjust the mass ratio of folic acid and hydroxycinnamic acid derivatives or folic acid and cinnamic acid to 10:0.1 (100g folic acid: 1g hydroxycinnamic acid derivatives) with buffer to make folic acid-cinnamic acid mixture or folic acid-hydroxycinnamic acid Mixture of acid derivatives.

Embodiment 2

[0025] The folic acid solution with a mass concentration of 1 g / L and any one of the cinnamic acid-ethanol solution or hydroxycinnamic acid derivative-ethanol solution with a mass concentration of 1 g / L are mixed in a ratio of 10:1 (10 g of folic acid : 1 g of hydroxycinnamic acid derivatives) Folic acid, cinnamic acid and hydroxycinnamic acid derivatives are mixed in a buffer solution with a pH of 6.0 to 8.0 to prepare a folic acid-cinnamic acid mixture or a folic acid-hydroxycinnamic acid derivative mixture .

Embodiment 3

[0027] Get the sample of embodiment 1,2, compare with the folic acid solution of the same concentration in the mixed solution, irradiate 240 minutes under ultraviolet light, measure by fluorescence spectrometry at excitation wavelength be 360nm, the fluorescence intensity at emission wavelength is 445nm place, and with The fluorescence intensity after 240 minutes of folic acid irradiation alone was normalized, and the results were expressed as relative fluorescence intensity.

[0028] like figure 1 and 2 As shown, the fluorescence intensity of folic acid itself is almost negligible, and the fluorescence intensity is significantly enhanced under ultraviolet light irradiation, indicating that folic acid molecules are constantly broken and degraded under light irradiation. As the UV irradiation time was extended to 120 minutes, the increase of fluorescence intensity gradually slowed down; after 200 minutes of irradiation, the fluorescence intensity no longer increased, indicatin...

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Abstract

The invention discloses a method for enhancing photostability of folic acid and belongs to the technical field of medicine preparation. The method disclosed by the invention comprises the following steps: adding a hydroxyl cinnamic acid derivative in the mass concentration more than or equal to 1/00 of the mass concentration of the folic acid into the folic acid, mixing and then preparing into a folic acid-hydroxyl cinnamic acid derivative mixed solution. The photostability of the folic acid in the folic acid-hydroxyl cinnamic acid derivative mixed solution prepared according to the method disclosed by the invention is high; in the folic acid-p-coumaric acid or folic acid-caffeic acid mixed solution at a mass ratio of 1:1, the residual rate of the folic acid after UV irradiation for 240 minutes is still 100%; the light degradation of the folic acid can be completely restrained; and the product can be applied to drugs, foods and cosmetics.

Description

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Claims

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Application Information

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Owner JIANGNAN UNIV
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