A kind of tilmicosin ultrafine powder water-soluble preparation and preparation method thereof

A tilmicosin and ultrafine technology, which is applied in powder delivery, antiviral agents, and pharmaceutical formulations, can solve the problems of large drug side effects, large drug dosage, and poor stability, and achieve fast drug metabolism and reasonable formula composition , the effect of good stability

Active Publication Date: 2019-07-12
XIAN LUCKYROAD BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the tilmicosin veterinary drug preparation produced by the prior art has poor solubility, large drug side effects, poor stability, large drug consumption, and slow metabolism, which easily cause secondary pollution to the environment

Method used

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  • A kind of tilmicosin ultrafine powder water-soluble preparation and preparation method thereof
  • A kind of tilmicosin ultrafine powder water-soluble preparation and preparation method thereof
  • A kind of tilmicosin ultrafine powder water-soluble preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of low-temperature airflow processing tilmicosin superfine powder water-soluble preparation, in terms of mass percentage, including 25% tilmicosin, 30% PVPK30, 30% PEG6000, 12% L-arginine, 3% Tween 80.

[0023] The preparation method of this tilmicosin superfine powder water-soluble preparation is as follows:

[0024] Step 1: According to tilmicosin accounts for 25% of the mass percentage of the ultrafine powder water-soluble preparation, PVPK30 accounts for 30% of the mass percentage of the water-soluble preparation, PEG6000 accounts for 30% of the mass percentage of the water-soluble preparation, and L-arginine accounts for the mass of the preparation Percentage of 12%, Tween-80 accounts for 3% of the mass percentage of the preparation to weigh tilmicosin, PVPK30, PEG6000, L-arginine, Tween 80 as standby.

[0025] Step 2: Place the weighed raw and auxiliary materials in a mixer and mix for 30-60 minutes.

[0026] Step 3: The uniformly mixed material enters th...

Embodiment 2

[0028] A kind of low-temperature air flow processing tilmicosin superfine powder water-soluble preparation, in terms of mass percentage, including 30% tilmicosin, 25% PVPK30, 30% PEG6000, 14% L-arginine, 1% Tween 80.

[0029] The preparation method of this tilmicosin superfine powder water-soluble preparation is as follows:

[0030] Step 1: According to tilmicosin accounts for 30% of the mass percentage of the ultrafine powder water-soluble preparation, PVPK30 accounts for 25% of the mass percentage of the water-soluble preparation, PEG6000 accounts for 30% of the mass percentage of the water-soluble preparation, and L-arginine accounts for the mass of the preparation Percentage of 14%, Tween-80 accounted for 1% of the mass percentage of the preparation to weigh tilmicosin, PVPK30, PEG6000, L-arginine, Tween 80 as standby.

[0031] Step 2: Place the weighed raw and auxiliary materials in a mixer and mix for 30-60 minutes.

[0032] Step 3: The uniformly mixed material enters ...

Embodiment 3

[0034] A kind of low-temperature air flow processing tilmicosin superfine powder water-soluble preparation, in terms of mass percentage, including 29% tilmicosin, 26% PVPK30, 30% PEG6000, 13% L-arginine, 2% Tween 80.

[0035] The preparation method of this tilmicosin superfine powder water-soluble preparation is as follows:

[0036] Step 1: According to tilmicosin accounts for 29% of the mass percentage of the ultrafine powder water-soluble preparation, PVPK30 accounts for 26% of the water-soluble preparation, PEG6000 accounts for 30% of the water-soluble preparation, and L-arginine accounts for the mass of the preparation Percentage of 13%, Tween-80 accounts for 2% of the mass percentage of the preparation to weigh tilmicosin, PVPK30, PEG6000, L-arginine, Tween 80 as standby.

[0037] Step 2: Place the weighed raw and auxiliary materials in a mixer and mix for 30-60 minutes.

[0038] Step 3: The uniformly mixed material enters the classifier through the feeding device for p...

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Abstract

The invention discloses a tilmicosin submicron powder water soluble preparation and a preparing method thereof, and belongs to the technical field of veterinary medicine preparing. The tilmicosin submicron powder water soluble preparation is soluble powder. The tilmicosin submicron powder water soluble preparation is prepared from, by mass, 15%-35% tilmicosin, 15%-35% PVPK30, 15-35% of PEG6000, 5%-20% L-arginine and 1%-5% Tween-80. The tilmicosin submicron powder water soluble preparation does not degrade, specific surface area is increased, the preparation can be well dispersed and easier to be absorbed, the dissolution rate of the tilmicosin is greatly increased, and the preparation has low moisture and few impurities. An acceleration test and long-term test inspection show that the preparation has good stability. A pharmacodynamic test is conducted on the prepared tilmicosin submicron powder water soluble preparation and finds that therapeutic effect for respiratory disease of the preparation is significantly higher than that of ordinary tilmicosin water soluble powder, the cure rate reaches up to 89.6%, and the effective rate reaches up to 94.6%.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a formula of tilmicosin superfine powder water-soluble preparation and a preparation method thereof. Background technique [0002] In recent years, the abuse of antibiotics is very common, and the problem of bacterial drug resistance is becoming more and more serious. In order to treat animals, antibiotics usually have to be increased several times to achieve a certain effect. The use of large doses of antibiotics leads to the inability of drugs to be metabolized in animals. Excreted, causing secondary pollution to water sources, soil and other environments. In order to prevent and control animal diseases, promote the healthy development of the breeding industry, maintain human health, and minimize the excretion of drug residues. Clinically, there is an urgent need to supplement or replace antibacterial drugs with less dosage, fast drug metabolism, defini...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/706A61K31/198A61K47/18A61K47/32A61K47/10A61P11/00A61P31/04A61P31/12
CPCA61K9/145A61K9/146A61K31/198A61K31/706A61K2300/00
Inventor 景战蕾杨艺吴小宁
Owner XIAN LUCKYROAD BIOLOGICAL TECH
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