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Pre-filled plastic syringe containing VEGF antagonist

A syringe, pre-filled technology, applied in the directions of syringes, hypodermic injection devices, medical preparations containing active ingredients, etc., can solve problems such as unclear syringes

Inactive Publication Date: 2017-02-22
FORMYCON AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is unclear whether the syringe can be used for ophthalmic applications

Method used

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  • Pre-filled plastic syringe containing VEGF antagonist
  • Pre-filled plastic syringe containing VEGF antagonist
  • Pre-filled plastic syringe containing VEGF antagonist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0092] 1. Different sized syringes were assayed in different plastic and glass syringes containing ranibizumab and subjected to different conditions. particles

[0093] Fill 400 μl of a solution of anti-VEGF antibody ranibizumab containing 1 mg / ml antibody and histidine buffer, trehalose dihydrate, polysorbate 20, pH 5.5 into the following syringe:

[0094] Table 1:

[0095]

[0096] Syringes from Table 1 were rotated from needle to stopper at 1 cycle / 10 sec at 40°C for 5 minutes, two weeks and four weeks, or subjected to five freeze / thaw cycles (from +5 to -20°C). Light obscuration was then measured with a FlowCam PV benchtop system (FluidImaging Technologies Inc., Maine, USA) using the system software (VisualSpreadsheet software, version 3.4.8) and the following parameters:

[0097]

[0098] The results of the analysis are shown in figure 1 and figure 2 middle. The prefilled silicone-free cycloolefin polymer syringes 1 and 8 had low particle levels under all ...

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Abstract

The present invention relates to a pre-filled syringe containing a VEGF antagonist and comprising a plastic barrel which is silicone-free, kits comprising this syringe and the use of the syringe for the administration of a VEGF antagonist in the treatment of ocular diseases.

Description

technical field [0001] The present invention relates to a pre-filled syringe containing a VEGF antagonist and comprising a silicone-free plastic barrel, a kit comprising the same and said syringe for administering a VEGF antagonist in the treatment of ocular diseases the use of. Background technique [0002] Eye diseases such as age-related macular degeneration and diabetic macular edema are caused by the uncontrolled growth of blood vessels in the eye. Therefore, one option for the treatment of these and similar diseases is to inhibit angiogenesis in the eye. Because VEGF is a key factor in stimulating angiogenesis, it is an attractive target for down-regulation of angiogenesis. [0003] by Marketed under the name Aflibercept is a recombinant fusion protein consisting of the VEGF-binding portion from the extracellular domains of human VEGF receptors 1 and 2 fused to the Fc portion of a human IgG1 immunoglobulin. It is approved for the treatment of wet macular degenerat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P27/02A61M5/31
CPCA61K39/39591A61M5/3129C07K16/22A61F9/0017A61K38/179A61K2039/54A61P27/02A61K39/3955A61M2205/02A61M2205/0238A61K39/395A61M5/31A61K9/08A61K2039/545A61M5/2033A61M5/31511A61M5/329C07K14/71C07K2319/30
Inventor 贝恩德·菲德勒
Owner FORMYCON AG
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