Salt of halogen-substituted heterocyclic compound

A halogen atom, cyclopropane carboxylic acid technology, applied in the direction of drug combination, organic chemistry, digestive system, etc., can solve the problem of undisclosed compounds and so on
CN106458964AActive Publication Date: 2017-02-22UBE IND LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UBE IND LTD
Publication Date
2017-02-22

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Abstract

The invention relates to a salt of halogen-substituted heterocyclic compound. Provided is a novel salt of an [alpha]-halogen-substituted thiophene compound that has powerful LPA receptor antagonistic action and that is useful as a pharmaceutical product. A salt represented by general formula (1) [In the formula: R is a hydrogen atom or a methoxy group; X is a halogen atom; A is a group selected from the group consisting of the following groups: (AA); M is an alkali metal or an alkali earth metal; and n is 1 when M is an alkali metal, and 2 when M is an alkali earth metal] (as shown in the description).
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Description

technical field

[0001] The present invention relates to novel salts of α-position halogen-substituted thiophene compounds useful as medicines. The salt of the α-position halogen-substituted thiophene compound of the present invention is useful for preventing and / or treating diseases caused by LPA because it has lysophosphatidic acid (LPA) receptor antagonistic activity. Background technique

[0002] Lysophosphatidic acid (LPA) is a physiologically active phospholipid present in living organisms. LPA binds to specific G protein-conjugated receptors (LPA1, LPA2, LPA3, LPA4, LPA5, LPA6) to transmit signals in cells, thereby regulating cell proliferation, differentiation, survival, migration, adhesion, infiltration, and morphology form. It is also known that LPA intervenes in diseases accompanied by fibrosis in various organs.

[0003] Regarding the liver, it has been reported that LPA promotes the proliferation and / or contraction of astrocytes, which play an important role i...

Claims

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