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Dynamic range improvement for isotope ratio mass spectrometry

A range, mass spectrometer technology, applied in the field of mass spectrometers, that can solve problems such as constraining instrument and detector array flexibility, high cost, high sample volume, etc.

Active Publication Date: 2017-03-01
THERMO FISHER SCI BREMEN
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing techniques are complex and thus expensive to implement and may have other disadvantages such as reduced throughput and / or require higher sample sizes
Known methods may also limit or constrain the flexibility of instrumentation and detector arrays for other applications

Method used

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  • Dynamic range improvement for isotope ratio mass spectrometry
  • Dynamic range improvement for isotope ratio mass spectrometry
  • Dynamic range improvement for isotope ratio mass spectrometry

Examples

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Embodiment Construction

[0025] As mentioned above, it is proposed to use some further detector or several further detectors to measure the background during the analysis. first reference figure 2 , shows a schematic illustration of the mass spectrometer 1 . The mass spectrometer 1 comprises: an ion source 10 ; ion optics 20 ; a mass-charge dispersing element 30 ; an ion detection arrangement 40 ; Ion optics 20 may include one or more optics selected from the group consisting of ion lenses, ion guides, and collision cells. The mass-charge dispersing element 30 is a sector magnetic field in this embodiment. The ion detection arrangement 40 is in the form of a collector array and comprises: a first main beam detector 41 ; a second main beam detector 42 ; a background level detector 43 ; and a shielding plate 45 . A first main beam detector 41 and a second main beam detector 42 as well as a background level detector 43 are positioned at the focal plane 35 of the sector magnetic field 30 .

[0026] T...

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Abstract

In a mass spectrometer, a mass-to-charge dispersive element separates received ions spatially according to their mass-to-charge ratios, to provide a dispersed ion beam thereby. An ion detection arrangement that detects the dispersed ion beam comprises: at least one primary ion detector, each detecting spatially separated ions having mass-to-charge ratios within a respective desired range and each providing a respective main beam signal based on its respective detected ions; and at least one secondary ion detector, each detecting ions having mass-to-charge ratios outside all of the desired ranges simultaneously with the at least one primary ion detector detecting the spatially separated ions and each providing a respective background signal based on its respective detected ions. At least one mass intensity measurement is provided for the received ions having a mass-to-charge ratio within the desired range, based on the at least one main beam signal and the at least one background signal.

Description

technical field [0001] The invention relates to a mass spectrometer, a controller for the mass spectrometer and a method for mass spectrometry, especially in the field of isotope ratio mass spectrometry. Background technique [0002] Multi-collector mass spectrometers are well known, especially for isotope separation. Mass-charge dispersing elements, such as magnetic sectors, spatially separate ions according to their mass-to-charge ratios. Multi-collector measurements are the preferred method for high-precision isotope ratio measurements because simultaneous detection of isotopes or isotopologues can eliminate the effect of signal fluctuations on the precision of the measured isotope ratios. The detector array can be fixed or movable. An example of such a mass spectrometer is described in EP-0 952 607 A2. [0003] Simultaneous measurement means that signal fluctuations are recorded simultaneously on all isotopes or isotopologues. These signal fluctuations therefore canc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62
CPCG01N27/62H01J49/0027H01J49/025H01J49/30B01D59/44H01J49/0036H01J49/009
Inventor J·拉德克A·希尔克特A·特林奎尔J·施韦特斯
Owner THERMO FISHER SCI BREMEN
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