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Application of lacidipine to preparing medicines for treating arenavirus infection

A technology of lacidipine and arenavirus, applied in the field of medicine, can solve problems such as undiscovered, achieve the effects of inhibiting virus infection, good safety and wide application prospect

Active Publication Date: 2017-03-22
WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no relevant reports about lacidipine anti-Lassa virus have been found

Method used

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  • Application of lacidipine to preparing medicines for treating arenavirus infection
  • Application of lacidipine to preparing medicines for treating arenavirus infection
  • Application of lacidipine to preparing medicines for treating arenavirus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The present embodiment provides a kind of lacidipine tablet for the treatment of arenavirus infection:

[0041] Get 100g lacidipine, 600g microcrystalline cellulose, 350g anhydrous lactose, 220g magnesium stearate and 30g silicon oxide, make tablet by known tablet technology and equipment, wherein the content of lacidipine is 10mg / piece .

Embodiment 2

[0043] The present embodiment provides a kind of lacidipine tablet for the treatment of arenavirus infection:

[0044] Get 100g lacidipine, 600g microcrystalline cellulose, 350g anhydrous lactose, 220g magnesium stearate and 30g silicon oxide, make tablet by known tablet technology and equipment, wherein the content of lacidipine is 40mg / piece .

Embodiment 3

[0046] The present embodiment provides a kind of lacidipine tablet for the treatment of arenavirus infection:

[0047] Get 100g lacidipine, 600g microcrystalline cellulose, 350g anhydrous lactose, 220g magnesium stearate and 30g silicon oxide, make tablet by known tablet technology and equipment, wherein the content of lacidipine is 25mg / piece .

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PUM

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Abstract

The invention provides application of lacidipine to preparing medicines for treating arenavirus infection, and belongs to the field of medicines. The application has the advantages that invasion of arenavirus into host cells can be effectively inhibited by the lacidipine in non-toxicity ranges, and accordingly virus infection due to the arenavirus can be effectively prevented and treated; the lacidipine is excellent in safety, further can be developed to obtain the medicines for treating or preventing the arenavirus infection and has a broad application prospect; the lacidipine further can be applied to preparing medicines for treating virus infection mediated by arenavirus envelope glycoprotein compounds and can act on the arenavirus envelope glycoprotein compounds, and accordingly the virus infection mediated by the arenavirus envelope glycoprotein compounds can be effectively inhibited; all different types of virus infection mediated by the arenavirus envelope glycoprotein compounds can be effectively treated and prevented by the lacidipine.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of lacidipine in the preparation of medicines for treating arenavirus infection. Background technique [0002] Arenaviruses are a class of RNA viruses that host rodents and can infect humans in various ways and cause diseases with varying degrees of fatality in humans. Recently, they have become locally prevalent in Africa and South America. Arenaviruses are double-segment negative-strand RNA viruses with envelopes. Virus particles are spherical or diverse, with a diameter of 50-300nm. Under an electron microscope, it can be observed that the cross-section of arenaviruses contains many granular Ribosomes, hence the name arenaviruses. [0003] Arenaviruses can be divided into two types according to genotype, serotype and occurrence area: the Old World group and the New World group. Old World viruses include Lassa fever virus and lymphocytic choriomeningitis virus, mainly ...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61P31/14
CPCA61K31/4422
Inventor 王薇王培林汪少伯刘洋肖庚富张磊砢
Owner WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
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