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A preparation method of silver selenium sulfur quantum dot nanoparticles

A nanoparticle and quantum dot technology, applied in the field of material chemistry, can solve the problems of limited application and achieve good imaging effect and wide photoluminescence wavelength range

Active Publication Date: 2019-02-15
苏州影睿光学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These greatly limit its application in the fields of biomarkers, imaging, clinical diagnosis, etc.

Method used

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  • A preparation method of silver selenium sulfur quantum dot nanoparticles
  • A preparation method of silver selenium sulfur quantum dot nanoparticles

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Mix 0.1 mmol of silver acetate, 10 g of dodecanethiol and 2 g of octadecene in a flask, 2 In the atmosphere, the temperature was raised to 160 °C, 0.03 mmol of selenium source was injected, and then the temperature was raised to 200 °C for 20 min. Finally, after the solution was naturally cooled to room temperature, 50 mL of acetone was added, centrifuged, washed, and dispersed in chloroform. The obtained sample uniform monodisperse silver selenium sulfur quantum dot nanoparticles (such as figure 1 shown), with good as figure 2 The near-infrared fluorescence emission spectrum shown; 0.2 gC18-PMH-PEG was added to the above chloroform solution, sonicated for 2 h, and then washed with N 2 Blow dry and disperse in 1x PBS solution. Use 808nm laser excitation, 1100nm filter, take pictures with 2D InGaAs camera, and carry out small animal live imaging.

Embodiment 2

[0031] Mix 0.1 mmol of silver nitrate and 10 g of octyl mercaptan in a flask, 2 In the atmosphere, the temperature was raised to 120 °C, 0.02 mmol of selenium source was injected, and then the temperature was raised to 185 °C to react for 20 h. Finally, after the solution was naturally cooled to room temperature, 50 mL of ethanol was added, centrifuged, washed, dispersed in chloroform, and 0.2 g of 11 -Mercaptoundecanoic acid was added to the above chloroform, sonicated for 3 h, then centrifuged, washed and dispersed in 1x PBS solution. Excited with an 808 nm laser, 1100 nm filter, and photographed with a 2D InGaAs camera for cell imaging.

Embodiment 3

[0033] Mix 0.1 mmol of silver trifluoroacetate, 10 g of stearyl mercaptan and 5 g of oleylamine in a flask, 2 In the atmosphere, the temperature was raised to 220 °C, 0.01 mmol of selenium source was injected, and then the temperature was raised to 250 °C for 2 h. Finally, after the solution was naturally cooled to room temperature, 50 mL of ethanol was added, centrifuged, washed, dispersed in dichloromethane, and Add 0.2 g of lipoic acid into the above dichloromethane, sonicate for 5 h, then centrifuge, wash and disperse in 1x PBS solution. Excited with 808 nm laser, 1100 nm filter, photographed with 2D InGaAs camera, for live imaging of small animals.

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Abstract

The invention relates to a novel ternary-component silver-selenium-sulfur quantum dot nano particle with a photoluminescence spectrum continuously adjustable along with a chemical composition and a preparation method thereof. In the silver-selenium-sulfur quantum dot nano particle, the mole ratio of silver to selenium to sulfur is 2 to X to (1-X). As X is changed, the silver-selenium-sulfur quantum dot nano particle has the photoluminescence spectrum in the range of 1100nm to 1620nm. The preparation method of the silver-selenium-sulfur quantum dot nano particle comprises the following steps of heating a silver source, thioalcohol and a solvent to 90 to 250 DEG C under the protection of an inert gas, injecting a selenium source into an obtained first mixture, and making an obtained second mixture react sufficiently; cooling a mixed reaction system, then adding a polar solvent into the mixed reaction system, and centrifuging and washing an obtained third mixture, so as to obtain the silver-selenium-sulfur quantum dot nano particle. The silver-selenium-sulfur quantum dot nano particle provided by the invention has a high fluorescent yield, good stability and a uniform size; the necessary preparation is provided for the research that such a material is used as a fluorescent marker to be applied to the fields of near-infrared biomarkers and image formation.

Description

technical field [0001] The invention particularly relates to a novel near-infrared quantum dot nanoparticle product, in particular to a silver selenium sulfur quantum dot nanoparticle and a method for preparing the silver selenium sulfur quantum dot nanoparticle, belonging to the technical field of material chemistry. Background technique [0002] As an important means of biomedical research, near-infrared fluorescence imaging technology has many unique advantages, such as large tissue penetration depth, low background fluorescence, and small scattering, especially in the second near-infrared region b range (1500-1700 nm) Within, the background fluorescence is almost zero, and has ultra-low scattering, so it has attracted widespread attention in biomedicine and other fields. At present, the common near-infrared second region b quantum dot nanoparticles contain toxic elements such as heavy metals Pb and Hg. The reported low-toxic or even non-toxic silver-based quantum dots w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/88G01N21/64
CPCC09K11/881G01N21/6486
Inventor 孙国凤刘莉丽
Owner 苏州影睿光学科技有限公司
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