Antibacterial nano fiber and preparation method thereof

A nanofiber and fiber technology, applied in textiles, papermaking, non-woven fabrics, etc., can solve the problems of low cost and good spinnability, and achieve the effects of low cost, strong application value and easy control.

Active Publication Date: 2017-05-17
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report in the field of combining nano-cuprous oxide with silk fibroin to prepare a kind of antibacterial nanofiber with good spinnability, low cost and environmental friendliness.

Method used

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  • Antibacterial nano fiber and preparation method thereof
  • Antibacterial nano fiber and preparation method thereof
  • Antibacterial nano fiber and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] First add 100 grams of cocoons to 1 liter of 0.5w / v% Na 2 CO 3 In the aqueous solution, boil for 30min, repeat the treatment three times, fully wash with distilled water, put it in a drying oven at 45°C after washing, and dry to obtain degummed silk fibers; 2 :C 2 h 5 OH:H 2 The molar ratio of O=1:2:8 is used to prepare a ternary solvent, and the silk fiber is hydrolyzed at a constant temperature in a water bath at 70° C. for 1 hour at a bath ratio of 1:10 to obtain a completely dissolved brownish-yellow silk fiber hydrolysis solution; Put the hydrolyzed solution into a dialysis bag, dialyze with distilled water for 72 hours, put the dialyzed silk fiber hydrolyzed solution into -80°C for 12 hours, and then freeze-dry it at -58°C until dry to obtain white, loose porous, spongy Silk fibroin: Compared with the existing commercially available silk fibroin, the silk fibroin prepared by the above steps of the present invention has the advantages of uniform molecular weigh...

Embodiment 2

[0034]Disperse 0.01 g of nano-cuprous oxide powder in 10 ml of deionized water, ultrasonicate for 2 hours, add 2.0 g of silk fibroin prepared in Example 1 and stir until completely dissolved to obtain a silk fibroin solution; dissolve 0.2 g of polyethylene oxide in 10 In milliliters of deionized water, stir until fully dissolved to obtain a polyethylene oxide solution with a mass fraction of 2.0%. 10 mL of silk fibroin solution containing nano-cuprous oxide is mixed with 10 mL of polyethylene oxide solution so that the mass ratio of the two solutions is 1:1, then electrospinning, spinning conditions: voltage, 12 kV; receiving distance, 150 mm; spinning rate, 0.8 ml / hour, to obtain an antibacterial nanofiber membrane with an average fiber diameter of 289±70 nm.

Embodiment 3

[0036] Disperse 0.005 g of nano-cuprous oxide powder in 10 ml of deionized water, ultrasonicate for 2 hours, add 2.0 g of silk fibroin prepared in Example 1 and stir until completely dissolved to obtain a silk fibroin solution with a volume and mass dispersion of 20.0%; 1 gram of polyethylene oxide was dissolved in 10 milliliters of deionized water, stirred until completely dissolved to obtain a polyethylene oxide solution with a mass fraction of 2.0%, and 10 mL of silk fibroin solution containing nanometer cuprous oxide was mixed with 10 mL of polyethylene oxide solution to make The mass ratio of the two solutions is 1:1, and then electrospinning is carried out. The spinning conditions are: voltage, 12 kV; receiving distance, 150 mm; spinning rate, 0.8 ml / hour, and the average fiber diameter is 337 ± 62 Nano antibacterial nanofiber membrane.

[0037] Before the antibacterial experiment, the antibacterial nanofiber membrane was treated with 75% ethanol vapor, which not only ma...

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Abstract

The invention discloses an antibacterial nano fiber and a preparation method thereof. The fiber is mainly prepared from nano cuprous oxide, silk fibroin and polyoxyethylene. The nano cuprous oxide has an antibacterial effect, the nano cuprous oxide can react with SH- and -S-S bonds in microbes to generate corresponding sulfydryl copper compounds to disturb the physiological reaction of the microbes and cause microbe death, meanwhile the nano cuprous oxide further has very strong adsorption property and can be absorbed onto bacterial surfaces to damage cell walls and cell membranes, penetrate into cell bodies and cause bacterium death. The polyoxyethylene can greatly increase the spinnability of the material, and the stability of the nano fiber and the formability of the fiber are improved. The silk fibroin has good breathability, moisture penetrability, biocompatibility, non-immunogenicity and other excellent properties and produces mutual effect and mutual synergism with the nano cuprous oxide and the polyoxyethylene, and the obtained fiber has excellent antibacterial properties and is wide in application range.

Description

technical field [0001] The invention belongs to the field of antibacterial nanofiber preparation, in particular to an antibacterial nanofiber (film) containing nano cuprous oxide, silk fibroin and polyethylene oxide and a preparation method thereof. Background technique [0002] Silk fibroin is degummed from silkworm cocoons. It is a natural protein that is very abundant in nature. It has excellent properties such as good air permeability, moisture permeability, biocompatibility, biodegradability, and non-immunogenicity. It has been widely used in the field of tissue engineering. Electrospun fibroin nanofibers have high porosity, high specific surface area, and good moisture and air permeability, and have become the preferred materials for skin tissue regeneration, wound healing, and skin care and health care. Patent ZL201019063008.1 discloses a preparation method of silk fibroin nanofibers loaded with vitamin C, and the fibers have skin care effects. Patent ZL201210014384...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4382D04H1/728
CPCD04H1/4382D04H1/728
Inventor 张葵花颜志勇张梦怡
Owner JIAXING UNIV
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