Preparation method for extracting edible and medicinal monomer for preventing and treating hyperuricemia and gout from Semen Cuscutae

A dual-use technology for hyperuricemia and medicine and food, which is applied in the fields of medical formula, tea processing before extraction, and the function of food ingredients, etc., can solve the problems of low yield of monomer compounds, high cost, time-consuming and heavy taste, etc. Achieve the effects of high yield, low cost and convenient administration

Inactive Publication Date: 2017-05-31
张清仲
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The curative effect of traditional Chinese medicine in treating hyperuricemia and gout is remarkable, but there are some deficiencies in the use of traditional Chinese medicine in several aspects: 1. Conventional preparation and taking methods are inconvenient, such as decoction, time-consuming, heavy taste when taking, and Due to the different decoction time and decoction methods of individuals, the curative effect cannot be fully guaranteed; 2. The dosage is large, and the dosage form prepared by decoction or direct crushing contains active components and ineffective components. The dosage is large and cannot reach The effect of treating specific diseases, and may produce toxic and side effects; 3. The use of modern separation and purification technology to obtain monomer compounds has low yield and high cost, and it is difficult to achieve large-scale and industrialization; 4. Realize the monomer compound through modern synthesis technology Compound groups are still technically difficult and costly

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method for extracting edible and medicinal monomer for preventing and treating hyperuricemia and gout from Semen Cuscutae
  • Preparation method for extracting edible and medicinal monomer for preventing and treating hyperuricemia and gout from Semen Cuscutae
  • Preparation method for extracting edible and medicinal monomer for preventing and treating hyperuricemia and gout from Semen Cuscutae

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1. Preparation of capsules based on the present invention

[0028] 1) Weigh out the raw material drug dodder, 3# empty capsule shells for use;

[0029] 2) Add 20 times the amount of 60% ethanol to the raw materials and soak for 1d, heat and reflux for 2 hours, add 15 times the amount of 60% ethanol and heat to reflux for 1.5 hours, combine the extracts, recover the ethanol under reduced pressure, and centrifuge the concentrated liquid to obtain the filtrate , On AB-8 type macroporous resin column, static adsorption for 2 hours, eluted with 10BV water, discarded the eluent, and then eluted with different concentrations of ethanol from low to high, and identified the eluent by thin layer chromatography Whether it contains a certain monomer in the monomer compound group and its relative content, collect and combine the eluent with a high proportion of the target compound, vacuum dry or spray dry to obtain a fine powder, add 6 times the amount of 20% starch paste to make...

Embodiment 2

[0030] Example 2. Preparation of tablets based on the present invention

[0031] 1) Weigh out the raw material medicine Cuscuta for use;

[0032] 2) Add 20 times the amount of 60% ethanol to the raw materials and soak for 1d, heat and reflux for 2 hours, add 15 times the amount of 60% ethanol and heat to reflux for 1.5 hours, combine the extracts, recover the ethanol under reduced pressure, and centrifuge the concentrated liquid to obtain the filtrate , On AB-8 type macroporous resin column, static adsorption for 2 hours, eluted with 10BV water, discarded the eluent, and then eluted with different concentrations of ethanol from low to high, and identified the eluent by thin layer chromatography Whether it contains a certain monomer in the monomer compound group and its relative content, collect and combine the eluent with a high proportion of the target compound, vacuum dry or spray dry to obtain a fine powder, add 5 times the amount of 20% starch paste, 1 times The amount of 10% ...

Embodiment 3

[0033] Example 3. Preparation of a mixture based on the present invention

[0034] 1) Weigh out the raw material medicine Cuscuta, 10ml oral liquid vial and cap for spare;

[0035] 2) Add 20 times the amount of 60% ethanol to the raw materials and soak for 1d, heat and reflux for 2 hours, add 15 times the amount of 60% ethanol and heat to reflux for 1.5 hours, combine the extracts, recover the ethanol under reduced pressure, and centrifuge the concentrated liquid to obtain the filtrate , On AB-8 type macroporous resin column, static adsorption for 2 hours, eluted with 10BV water, discarded the eluent, and then eluted with different concentrations of ethanol from low to high, and identified the eluent by thin layer chromatography Whether it contains a certain monomer in the monomer compound group and its relative content, collect and combine the eluent with a high proportion of the target compound, concentrate to a relative density of 1.2, add sweeteners, preservatives, clarifiers, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a preparation method for extracting an edible and medicinal monomer for preventing and treating hyperuricemia and gout from Semen Cuscutae. The method comprises the following steps: crushing the Semen Cuscutae raw material, adding ethanol and heating and refluxing for crude extraction, purifying with a macroporous resin column, detecting and analyzing an eluant by thin layer chromatography, collecting an eluant with a high-proportion target compound and merging, and making the eluant into the product. Semen Cuscutae contains a phenylpropanoid compound. The monomer of the invention is composed of a bistetrahydrofuran ring connecting with glycosyl, has good dissolvability in medium polar solvents, such as n-butanol, ethyl acetate, etc., and has certain water solubility. According to the invention, 60% ethanol is used for decoction extraction, polar macroporous resin is used for purification, and a target monomeric compound group is purposefully enriched. The method is low-cost, has high yield, and is easy for realization of industrialization and mass production. Capsules, tablets, health-care medicinal tea, etc. prepared from the above product are convenient to use and have diversity.

Description

Technical field [0001] The invention relates to a preparation method of a medicinal and food dual-purpose monomer, in particular to a preparation method of extracting a medicinal and food dual-purpose monomer from a dodder seed for preventing and treating hyperuricemia and gout. Background technique [0002] There are many reports on the treatment of hyperuricemia and primary gout with traditional Chinese medicine. In clinical practice and daily life, people have found some effective single Chinese medicines that can treat hyperuricemia, and the active ingredients and pharmacological effects of many of them have been clarified. Such as vine, Qin Pi, Bai Ai, Artichoke, Wei Lingxian, Plantago Seed, Cork, Lysimachia, Gentiana, etc. have a certain effect of lowering uric acid [1,2] . Studies have shown that Epimedium, Coix Seed, Alisma, Plantago, Gentiana can increase the excretion of uric acid, and Gentiana can also increase the dissolution of uric acid; Eupatorium and Angelica can...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/39A61K36/43A61P19/06A23F3/14A23L29/00
CPCA61K36/39A23F3/14A23V2002/00A61K36/43A61K2236/333A61K2236/39A61K2236/55A23V2200/30
Inventor 张清仲
Owner 张清仲
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap