Preparation method for extracting pharmaceutical monomer for preventing and treating hyperuricemia and gout from rhizoma smilacis glabrae

A technology for hyperuricemia and Smilax tuckahoe, which is applied in medical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of low yield of monomer compounds, high cost, time-consuming and heavy taste, and achieve High yield, low cost, and convenient administration

Inactive Publication Date: 2017-02-08
张清仲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The curative effect of traditional Chinese medicine in treating hyperuricemia and gout is remarkable, but there are some deficiencies in the use of traditional Chinese medicine in several aspects: 1. Conventional preparation and taking methods are inconvenient, such as decoction, time-consuming, heavy taste when taking, and Due to the different decoction time and decoction methods of individuals, the curative effect cannot be fully guaranteed; 2. The dosage is large, and the dosage form prepared by decoction or direct crushing contains active components and ineffective components. The dosage is large and cannot reach The effect of treating specific diseases, and may produce toxic and side effects; 3. The use of modern separation and purification technology to obtain monomer compounds has low yield and high cost, and it is difficult to achieve large-scale and industrialization; 4. Realize the monomer compound through modern synthesis technology Compound groups are still technically difficult and costly

Method used

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  • Preparation method for extracting pharmaceutical monomer for preventing and treating hyperuricemia and gout from rhizoma smilacis glabrae
  • Preparation method for extracting pharmaceutical monomer for preventing and treating hyperuricemia and gout from rhizoma smilacis glabrae

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Effect test

Embodiment 1

[0024] Embodiment 1, acute toxicity test of the present invention

[0025] Experimental animals: KM mice, SPF grade, male, weighing 18-22 g, provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine. After 3 days of normal feeding, it was tested.

[0026] Drugs and Reagents: Smilax Smilax (Guangzhou Medicinal Herbal Pieces Factory).

[0027] A preparation method for extracting and preventing hyperuricemia and gout medicinal monomer from Smilax smilax according to the present invention, the steps are as follows:

[0028] Add 20 times the amount of 70% ethanol to the raw material Smilax tuckahoe, heat and reflux for 2 hours, add 15 times the amount of 70% ethanol to heat and reflux for 1.5 hours, combine the extracts, refrigerate for 1 day, centrifuge at high speed, discard the insoluble matter, and recover the ethanol under reduced pressure to Relative density 1.2, hydrochloric acid to adjust the pH value to 5, refrigerated for 1 day, ...

Embodiment 2

[0032] Embodiment 2, subchronic toxicity test of the present invention

[0033] Experimental animals: KM mice, SPF grade, male, weighing 18-22 g, provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine. After 3 days of normal feeding, it was tested.

[0034] Drugs and Reagents: Smilax Smilax (Guangzhou Medicinal Herbal Pieces Factory).

[0035] A preparation method for extracting and preventing hyperuricemia and gout medicinal monomer from Smilax smilax according to the present invention, the steps are as follows:

[0036] Add 20 times the amount of 70% ethanol to the raw material Smilax tuckahoe, heat and reflux for 2 hours, add 15 times the amount of 70% ethanol to heat and reflux for 1.5 hours, combine the extracts, refrigerate for 1 day, centrifuge at high speed, discard the insoluble matter, and recover the ethanol under reduced pressure to Relative density 1.2, hydrochloric acid to adjust the pH value to 5, refrigerated for 1 da...

Embodiment 3

[0041] Embodiment 3, the clinical observation of clinical treatment hyperuricemia and gout of the present invention

[0042] 1. Basic information: All cases come from outpatient clinics, a total of 60 cases, 30 cases for men and 30 cases for men and women. Using the random number table, they were divided into a treatment group of 30 cases and a control group of 30 cases. There was no statistically significant difference in gender, age, and course of disease between the two groups.

[0043] 2. Diagnostic criteria

[0044] 2.1 Western medicine diagnostic criteria

[0045] ①According to the standards set in the "Guidelines for Clinical Diagnosis and Treatment Rheumatism Volume" compiled by the Chinese Medical Association in 2005: male blood uric acid value>417mmol / L; female blood uric acid value>357mmol / L; 1977 American Rheumatism Association standard) (1), specific uric acid crystals were found in synovial fluid; (2), tophi was confirmed to contain sodium urate crystals by che...

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Abstract

The invention relates to a preparation method for extracting a pharmaceutical monomer for preventing and treating hyperuricemia and gout from rhizoma smilacis glabrae. The preparation method comprises: after crushing rhizoma smilacis glabrae raw materials, adding ethanol and heating and reflowing to carry out crude extraction; then adjusting the pH (Potential of Hydrogen) of crude extraction liquid to carry out crude purification; purifying by adopting a polyamide resin column and a macroporous resin column; identifying elution liquid through a thin-layer chromatography; collecting the elution liquid containing a target compound with a high ratio and combining; finally, preparing the elution liquid into a product. By adopting 70% ethanol to decoct and extract and utilizing polyamide resin and macroporous resin to purify, a target monomer compound group is enriched purposefully, the cost is low and the yield is high; industrialization and scale production are easy to realize. Preparations including capsules, tablets, health-care tea and the like, which are prepared by the preparation method, have the characteristics of convenience for oral administration and diversification.

Description

technical field [0001] The invention relates to a preparation method of a medicinal monomer for preventing and treating hyperuricemia and gout, in particular to a preparation method for extracting a medicinal monomer for preventing and treating hyperuricemia and gout from Smilax smilax. Background technique [0002] There are many reports on the treatment of hyperuricemia and primary gout by traditional Chinese medicine. In clinical practice and daily life, people have discovered some effective single Chinese medicines that can treat hyperuricemia, and the active ingredients and pharmacological effects of many of these medicines have been elucidated. Such as 萆薢, Qinpi, Baiai, artichoke, clematis, plantain seed, Phellodendron, Desmodium, Gentiana, etc. have a certain effect of lowering uric acid [1,2] . Studies have shown that Epimedium, Coix Seed, Alisma, Plantago, and Gentiana can increase the excretion of uric acid, and Gentiana can also increase the dissolution of uric ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/90A61P19/06A23F3/34
CPCA61K36/896A23F3/34A61K9/0095A61K9/1652A61K9/2059A61K36/90A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 张清仲
Owner 张清仲
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